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We study the problem of selecting limited features to observe such that models trained on them can perform well simultaneously across multiple subpopulations. This problem has applications in settings where collecting each feature is…

Machine Learning · Computer Science 2025-10-27 Maitreyi Swaroop , Tamar Krishnamurti , Bryan Wilder

Model complexity in amplitude analyses is often a priori under-constrained since the underlying theory permits a large number of possible amplitudes to contribute to most physical processes. The use of an overly complex model results in…

Data Analysis, Statistics and Probability · Physics 2015-09-30 Baptiste Guegan , John Hardin , Justin Stevens , Mike Williams

State of the art machine learning algorithms are highly optimized to provide the optimal prediction possible, naturally resulting in complex models. While these models often outperform simpler more interpretable models by order of…

Machine Learning · Statistics 2016-11-24 Yotam Hechtlinger

Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui

Being able to interpret, or explain, the predictions made by a machine learning model is of fundamental importance. This is especially true when there is interest in deploying data-driven models to make high-stakes decisions, e.g. in…

Machine Learning · Computer Science 2019-10-01 An-phi Nguyen , María Rodríguez Martínez

The complexity of linear mixed-effects (LME) models means that traditional diagnostics are rendered less effective. This is due to a breakdown of asymptotic results, boundary issues, and visible patterns in residual plots that are…

Methodology · Statistics 2016-12-08 Adam Loy , Heike Hofmann , Dianne Cook

When using machine learning for imbalanced binary classification problems, it is common to subsample the majority class to create a (more) balanced training dataset. This biases the model's predictions because the model learns from data…

Machine Learning · Computer Science 2025-11-03 Nathan Phelps , Daniel J. Lizotte , Douglas G. Woolford

Model-based Reinforcement Learning (RL) integrates learning and planning and has received increasing attention in recent years. However, learning the model can incur a significant cost (in terms of sample complexity), due to the need to…

Machine Learning · Computer Science 2023-03-17 Jiajun Shen , Kananart Kuwaranancharoen , Raid Ayoub , Pietro Mercati , Shreyas Sundaram

Model merging, particularly through weight averaging, has shown surprising effectiveness in saving computations and improving model performance without any additional training. However, the interpretability of why and how this technique…

Machine Learning · Computer Science 2025-08-20 Hu Wang , Congbo Ma , Ibrahim Almakky , Ian Reid , Gustavo Carneiro , Mohammad Yaqub

Mathematical models come in many forms across biological applications. In the case of complex, spatial dynamics and pattern formation, stochastic models also face two main challenges: pattern data is largely qualitative, and model…

Cell Behavior · Quantitative Biology 2022-12-26 Electa Cleveland , Angela Zhu , Bjorn Sandstede , Alexandria Volkening

Modeling an unknown dynamical system is crucial in order to predict the future behavior of the system. A standard approach is training recurrent models on measurement data. While these models typically provide exact short-term predictions,…

Machine Learning · Computer Science 2023-03-02 Katharina Ensinger , Sebastian Ziesche , Barbara Rakitsch , Michael Tiemann , Sebastian Trimpe

Mathematical models are increasingly being used to understand complex biochemical systems, to analyze experimental data and make predictions about unobserved quantities. However, we rarely know how robust our conclusions are with respect to…

Molecular Networks · Quantitative Biology 2015-11-06 Elisenda Feliu , Carsten Wiuf

Model transformation tools assist system designers by reducing the labor--intensive task of creating and updating models of various aspects of systems, ensuring that modeling assumptions remain consistent across every model of a system, and…

Systems and Control · Computer Science 2019-07-02 Natasha Jarus , Sahra Sedigh Sarvestani , Ali Hurson

We investigate a selection-mutation model for the dynamics of technological innovation,a special case of reaction-diffusion equations. Although mutations are assumed to increase the variety of technologies, not their average success…

Statistical Mechanics · Physics 2007-05-23 Dirk Helbing , Martin Treiber , Nicole J. Saam

The exploration of complex physical or technological processes usually requires exploiting available information from different sources: (i) physical laws often represented as a family of parameter dependent partial differential equations…

Numerical Analysis · Mathematics 2020-02-04 Albert Cohen , Wolfgang Dahmen , Ron DeVore

A common approach in computational science is to use a set of of highly precise but expensive calculations to parameterize a model that allows less precise, but more rapid calculations on larger scale systems. Least-squares fitting on a…

Materials Science · Physics 2015-05-13 Eric Cockayne , Axel van de Walle

For the last two decades, high-dimensional data and methods have proliferated throughout the literature. Yet, the classical technique of linear regression has not lost its usefulness in applications. In fact, many high-dimensional…

Statistics Theory · Mathematics 2021-05-18 Arun Kumar Kuchibhotla , Lawrence D. Brown , Andreas Buja , Edward I. George , Linda Zhao

The impressive performance of deep learning architectures is associated with a massive increase in model complexity. Millions of parameters need to be tuned, with training and inference time scaling accordingly, together with energy…

Machine Learning · Computer Science 2023-11-10 Paolo Didier Alfano , Vito Paolo Pastore , Lorenzo Rosasco , Francesca Odone

Over the past decade, random forest models have become widely used as a robust method for high-dimensional data regression tasks. In part, the popularity of these models arises from the fact that they require little hyperparameter tuning…

Machine Learning · Computer Science 2020-03-18 Shipra Malhotra , John Karanicolas

Imputing missing values is an important preprocessing step in data analysis, but the literature offers little guidance on how to choose between different imputation models. This letter suggests adopting the imputation model that generates a…

Methodology · Statistics 2021-07-13 Moritz Marbach
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