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The gradual accumulation of damage and dysregulation during the aging of living organisms can be quantified. Even so, the aging process is complex and has multiple interacting physiological scales -- from the molecular to cellular to whole…

Quantitative Methods · Quantitative Biology 2021-05-06 Spencer Farrell , Garrett Stubbings , Kenneth Rockwood , Arnold Mitnitski , Andrew Rutenberg

Mixture models are often used to identify meaningful subpopulations (i.e., clusters) in observed data such that the subpopulations have a real-world interpretation (e.g., as cell types). However, when used for subpopulation discovery,…

Methodology · Statistics 2024-03-04 Jiawei Li , Jonathan H. Huggins

There has been recent interest in improving performance of simple models for multiple reasons such as interpretability, robust learning from small data, deployment in memory constrained settings as well as environmental considerations. In…

Machine Learning · Computer Science 2020-06-23 Amit Dhurandhar , Karthikeyan Shanmugam , Ronny Luss

In modern applications, statisticians are faced with integrating heterogeneous data modalities relevant for an inference, prediction, or decision problem. In such circumstances, it is convenient to use a graphical model to represent the…

Methodology · Statistics 2017-08-30 Pierre E. Jacob , Lawrence M. Murray , Chris C. Holmes , Christian P. Robert

Tree ensembles, such as random forests and boosted trees, are renowned for their high prediction performance. However, their interpretability is critically limited due to the enormous complexity. In this study, we present a method to make a…

Machine Learning · Statistics 2017-03-01 Satoshi Hara , Kohei Hayashi

The ability to interpret machine learning models has become increasingly important now that machine learning is used to inform consequential decisions. We propose an approach called model extraction for interpreting complex, blackbox…

Machine Learning · Computer Science 2018-03-14 Osbert Bastani , Carolyn Kim , Hamsa Bastani

Models often need to be constrained to a certain size for them to be considered interpretable. For example, a decision tree of depth 5 is much easier to understand than one of depth 50. Limiting model size, however, often reduces accuracy.…

Machine Learning · Computer Science 2020-07-02 Abhishek Ghose , Balaraman Ravindran

We consider the challenges that arise when fitting complex ecological models to 'large' data sets. In particular, we focus on random effect models which are commonly used to describe individual heterogeneity, often present in ecological…

Methodology · Statistics 2022-05-17 Ruth King , Blanca Sarzo , Víctor Elvira

Model performance is frequently reported only for the overall population under consideration. However, due to heterogeneity, overall performance measures often do not accurately represent model performance within specific subgroups. We…

Methodology · Statistics 2025-06-03 Ruotao Zhang , Constantine Gatsonis , Jon Steingrimsson

Identifying and understanding modular organizations is centrally important in the study of complex systems. Several approaches to this problem have been advanced, many framed in information-theoretic terms. Our treatment starts from the…

Adaptation and Self-Organizing Systems · Physics 2015-01-19 Artemy Kolchinsky , Luis M. Rocha

Computational models of complex systems are usually elaborate and sensitive to implementation details, characteristics which often affect their verification and validation. Model replication is a possible solution to this issue. It avoids…

Other Computer Science · Computer Science 2017-01-09 Nuno Fachada , Vitor V. Lopes , Rui C. Martins , Agostinho C. Rosa

The use of multiple Decision Models (DMs) enables to enhance the accuracy in decisions and at the same time allows users to evaluate the confidence in decision making. In this paper we explore the ability of multiple DMs to learn from a…

Artificial Intelligence · Computer Science 2008-05-27 Vitaly Schetinin , Dayou Li , Carsten Maple

The problem of model collapse has presented new challenges in iterative training of generative models, where such training with synthetic data leads to an overall degradation of performance. This paper looks at the problem from a…

Machine Learning · Statistics 2026-02-19 Soham Bakshi , Sunrit Chakraborty

Many automated system analysis techniques (e.g., model checking, model-based testing) rely on first obtaining a model of the system under analysis. System modeling is often done manually, which is often considered as a hindrance to adopt…

Software Engineering · Computer Science 2019-11-22 Jingyi Wang , Jun Sun , Qixia Yuan , Jun Pang

Standard selection criteria for forecasting models focus on information that is calculated for each series independently, disregarding the general tendencies and performances of the candidate models. In this paper, we propose a new way to…

Methodology · Statistics 2021-04-21 Fotios Petropoulos , Evangelos Spiliotis , Anastasios Panagiotelis

Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be understood and…

Other Quantitative Biology · Quantitative Biology 2020-08-21 Tamàs Fülöp , Mathieu Desroches , Fernando Antônio Nóbrega Santos , Serafim Rodrigues

Model selection requires repeatedly evaluating models on a given dataset and measuring their relative performances. In modern applications of machine learning, the models being considered are increasingly more expensive to evaluate and the…

Machine Learning · Computer Science 2020-10-21 Anant Raj , Cameron Musco , Lester Mackey , Nicolo Fusi

Uplift modeling and Heterogeneous Treatment Effect (HTE) estimation aim at predicting the causal effect of an action, such as a medical treatment or a marketing campaign on a specific individual. In this paper, we focus on data from…

Machine Learning · Computer Science 2024-12-16 Krzysztof Rudaś , Szymon Jaroszewicz

A model among many may only be best under certain states of the world. Switching from a model to another can also be costly. Finding a procedure to dynamically choose a model in these circumstances requires to solve a complex estimation…

Machine Learning · Computer Science 2023-10-10 Francesco Cordoni , Alessio Sancetta

Complex black-box predictive models may have high performance, but lack of interpretability causes problems like lack of trust, lack of stability, sensitivity to concept drift. On the other hand, achieving satisfactory accuracy of…

Machine Learning · Computer Science 2020-02-12 Alicja Gosiewska , Przemyslaw Biecek