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Electrical brain stimulation is currently being investigated as a therapy for neurological disease. However, opportunities to optimize such therapies are challenged by the fact that the beneficial impact of focal stimulation on both…

Cell assemblies manipulation by optogenetics is pivotal to advance neuroscience and neuroengineering. In in vivo applications, photostimulation often broadly addresses a population of cells simultaneously, leading to feed-forward and to…

Neurons and Cognition · Quantitative Biology 2016-04-08 Rocco Pulizzi , Gabriele Musumeci , Chris Van Den Haute , Sebastian Van De Vijver , Veerle Baekelandt , Michele Giugliano

Optical neural networks (ONNs) perform extensive computations using photons instead of electrons, resulting in passively energy-efficient and low-latency computing. Among various ONNs, the diffractive optical neural networks (DONNs)…

Biotechnology can benefit from dynamic control to improve production efficiency. In this context, optogenetics enables modulation of gene expression using light as an external input, allowing fine-tuning of protein levels to unlock dynamic…

Systems and Control · Electrical Eng. & Systems 2026-05-11 Sebastián Espinel-Ríos

Optical communication achieves high fanout and short delay advantageous for information integration in neural systems. Superconducting detectors enable signaling with single photons for maximal energy efficiency. We present designs of…

Neural and Evolutionary Computing · Computer Science 2018-11-14 Jeffrey M. Shainline , Sonia M. Buckley , Adam N. McCaughan , Jeff Chiles , Richard P. Mirin , Sae Woo Nam

Photonic neural networks benefit from both the high channel capacity- and the wave nature of light acting as an effective weighting mechanism through linear optics. The neuron's activation function, however, requires nonlinearity which can…

Optical computing could reduce the energy cost of artificial intelligence by leveraging the parallelism and propagation speed of light. However, implementing nonlinear activation, essential for machine learning, remains challenging in…

Optics · Physics 2026-01-01 Bahadır Utku Kesgin , Gülsüm Yaren Durdu , Uğur Teğin

Excitable optoelectronic devices represent one of the key building blocks for implementation of artificial spiking neurons in neuromorphic (brain-inspired) photonic systems. This work introduces and experimentally investigates an…

Stimulation of target neuronal populations using optogenetic techniques during specific sleep stages has begun to elucidate the mechanisms and effects of sleep. To conduct closed-loop optogenetic sleep studies in untethered animals, we…

Neurons and Cognition · Quantitative Biology 2021-08-30 Xilin Liu , Andrew G. Richardson

Software-implementation, via neural networks, of brain-inspired computing approaches underlie many important modern-day computational tasks, from image processing to speech recognition, artificial intelligence and deep learning…

Optics · Physics 2021-02-19 J. Feldmann , N. Youngblood , C. D. Wright , H. Bhaskaran , W. H. P. Pernice

We report a multi-modal spiking neuron that allows optical and electronic input and control, and wavelength-multiplexing operation, for use in novel high-speed neuromorphic sensing and computing functionalities. The photonic-electronic…

A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the routing of information…

Neurons and Cognition · Quantitative Biology 2012-04-04 Michael V. Baratta , Shinya Nakamura , Peter Dobelis , Matthew B. Pomrenze , Samuel D. Dolzani , Donald C. Cooper

The design and benchtop operation of a wireless miniature epiretinal stimulator implant is reported. The implant is optically powered and controlled using safe illumination at near-infrared wavelengths. An application-specific integrated…

Networks of superconducting optoelectronic neurons are investigated for their near-term technological potential and long-term physical limitations. Networks with short average path length, high clustering coefficient, and power-law degree…

Neural and Evolutionary Computing · Computer Science 2018-05-17 Jeffrey M. Shainline , Jeff Chiles , Sonia M. Buckley , Adam N. McCaughan , Richard P. Mirin , Sae Woo Nam

Optical neural networks promise ultrafast, low-energy information processing by performing computation directly with photons. Current implementations, however, are largely restricted to steady-state operation and rely on high-latency…

Quantum Physics · Physics 2026-05-19 Jiande Cao , Yexiong Zeng , Franco Nori , Ze-Liang Xiang

Optics offers unique opportunities for reducing energy in information processing and communications while resolving the problem of interconnect bandwidth density inside machines. Such energy dissipation overall is now at environmentally…

Optics · Physics 2017-01-30 David A. B. Miller

Clinical trials previously demonstrated the notable capacity to elicit visual percepts in blind patients affected with retinal diseases by electrically stimulating the remaining neurons on the retina. However, these implants restored very…

In this paper, we provide an energy efficient self- healing mechanism for Wireless Sensor Networks. The proposed solution is based on our probabilistic sentinel scheme. To reduce energy consumption while maintaining good connectivity…

Networking and Internet Architecture · Computer Science 2014-10-02 Dame Diongue , Ousmane Thiare

Deep neural networks (DNNs) are reshaping the field of information processing. With their exponential growth challenging existing electronic hardware, optical neural networks (ONNs) are emerging to process DNN tasks in the optical domain…

Therapeutic intervention in neurological disorders still relies heavily on pharmacological solutions, while the treatment of patients with drug resistance remains an open challenge. This is particularly true for patients with epilepsy, 30%…

Human-Computer Interaction · Computer Science 2022-10-20 Margherita Ronchini , Yasser Rezaeiyan , Milad Zamani , Gabriella Panuccio , Farshad Moradi