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Weight gain is a well-established side effect of both conventional and newer anti-psychotic drugs, but the cause is not well understood. Recent studies correlate obesity with the presence or absence of particular genetic sequences in the…

Genomics · Quantitative Biology 2014-01-13 Harshad Joshi , Ankita Parihar , Dazhi Jiao , Shwetha Murali , David J. Wild

In pharmaceutical R&D, predicting the efficacy of a pharmaceutical in treating a particular disease prior to clinical testing or any real-world use has been challenging. In this paper, we propose a flexible and modular machine…

Machine Learning · Computer Science 2025-09-10 Adrien Couetoux , Thomas Devenyns , Lise Diagne , David Champagne , Pierre-Yves Mousset , Chris Anagnostopoulos

The role of the microbiome in disease pathogenesis is an emerging field with strong evidence suggesting that dysbiosis is associated with precancerous and cancerous states. Microbiome data present substantial challenges for causal mediation…

Methodology · Statistics 2026-05-07 Seungjun Ahn , Quran Wu , Alicia Yang , Zhigang Li

Effective plant growth and yield prediction is an essential task for greenhouse growers and for agriculture in general. Developing models which can effectively model growth and yield can help growers improve the environmental control for…

Machine Learning · Computer Science 2019-07-03 Bashar Alhnaity , Simon Pearson , Georgios Leontidis , Stefanos Kollias

Recent multi-omic microbiome studies enable integrative analysis of microbes and metabolites, uncovering their associations with various host conditions. Such analyses require multivariate models capable of accounting for the complex…

This work introduces a novel probabilistic deep learning technique called deep Gaussian mixture ensembles (DGMEs), which enables accurate quantification of both epistemic and aleatoric uncertainty. By assuming the data generating process…

Machine Learning · Statistics 2023-06-13 Yousef El-Laham , Niccolò Dalmasso , Elizabeth Fons , Svitlana Vyetrenko

Because the appropriate combination of existing elements and establishing coordination between them as a consequence of making the right decision to accomplish the intended objective is achieved, management is now one of the main pillars of…

Metric Geometry · Mathematics 2025-04-29 Hamid Babaei , Shabnam Mohammadi , Hossein Ghaneai

Neural networks are the cornerstone of modern machine learning, yet can be difficult to interpret, give overconfident predictions and are vulnerable to adversarial attacks. Bayesian neural networks (BNNs) provide some alleviation of these…

Machine Learning · Statistics 2026-02-24 August Arnstad , Leiv Rønneberg , Geir Storvik

Gradient boosted trees are competition-winning, general-purpose, non-parametric regressors, which exploit sequential model fitting and gradient descent to minimize a specific loss function. The most popular implementations are tailored to…

Machine Learning · Computer Science 2022-08-23 Lorenzo Nespoli , Vasco Medici

It is common that a trained classification model is applied to the operating data that is deviated from the training data because of noise. This paper demonstrates that an ensemble classifier, Diversified Multiple Tree (DMT), is more robust…

Machine Learning · Computer Science 2017-06-27 Jiuyong Li , Lin Liu , Jixue Liu , Ryan Green

In this article, we develop a new class of multivariate distributions adapted for count data, called Tree P\'olya Splitting. This class results from the combination of a univariate distribution and singular multivariate distributions along…

Statistics Theory · Mathematics 2025-01-30 Samuel Valiquette , Jean Peyhardi , Éric Marchand , Gwladys Toulemonde , Frédéric Mortier

Heart disease is a serious global health issue that claims millions of lives every year. Early detection and precise prediction are critical to the prevention and successful treatment of heart related issues. A lot of research utilizes…

Machine Learning · Computer Science 2024-07-30 Rahul Karmakar , Udita Ghosh , Arpita Pal , Sattwiki Dey , Debraj Malik , Priyabrata Sain

This study aims to optimize Deep Feedforward Neural Networks (DFNNs) training using nature-inspired optimization algorithms, such as PSO, MTO, and its variant called MTOCL. We show how these algorithms efficiently update the weights of…

Machine Learning · Computer Science 2021-05-24 Wael Korani , Malek Mouhoub , Samira Sadaoui

The proliferation of healthcare data has brought the opportunities of applying data-driven approaches, such as machine learning methods, to assist diagnosis. Recently, many deep learning methods have been shown with impressive successes in…

Machine Learning · Statistics 2018-09-03 Haohan Wang , Zhenglin Wu , Eric P. Xing

There is a dearth of robust methods to estimate the causal effects of multiple treatments when the outcome is binary. This paper uses two unique sets of simulations to propose and evaluate the use of Bayesian Additive Regression Trees…

Methodology · Statistics 2020-01-22 Liangyuan Hu , Chenyang Gu , Michael Lopez , Jiayi Ji , Juan Wisnivesky

We develop Clustered Random Forests, a random forests algorithm for clustered data, arising from independent groups that exhibit within-cluster dependence. The leaf-wise predictions for each decision tree making up clustered random forests…

Methodology · Statistics 2026-01-26 Elliot H. Young , Peter Bühlmann

The modelling of action potentials from extracellular recordings, or spike sorting, is a rich area of neuroscience research in which latent variable models are often used. Two such models, Overfitted Finite Mixture models (OFMs) and…

Applications · Statistics 2016-02-08 Zoé van Havre , Nicole White , Judith Rousseau , Kerrie Mengersen

This paper proposes a hierarchical Bayesian multitask learning model that is applicable to the general multi-task binary classification learning problem where the model assumes a shared sparsity structure across different tasks. We derive a…

We introduce the SoftBart approach from Bayesian ensemble learning to estimate the relationship between multipollutant mixtures and health on chronic exposures in epidemiology research. This approach offers several key advantages over…

Quantitative Methods · Quantitative Biology 2025-05-26 Yu-Chien Ning , Xin Zhou , Francine Laden , Molin Wang

Nutrition estimation is crucial for effective dietary management and overall health and well-being. Existing methods often struggle with sub-optimal accuracy and can be time-consuming. In this paper, we propose NuNet, a transformer-based…

Computer Vision and Pattern Recognition · Computer Science 2024-06-05 Zhengyi Kwan , Wei Zhang , Zhengkui Wang , Aik Beng Ng , Simon See