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Evaluating the influence of continuous covariates, like exposure time or dose, on a response variable is a pivotal objective in the assessment of a compound's effect, particularly when determining toxicity in pre-clinical research or…

Methodology · Statistics 2026-04-16 Lucia Ameis , Niklas Hagemann , Kathrin Möllenhoff

Micro Abstract: A recent study from GLOBOCAN disclosed that during 2018 two million women worldwide had been diagnosed from breast cancer. This study presents a computer-aided diagnosis system based on convolutional neural networks as an…

Computer Vision and Pattern Recognition · Computer Science 2019-10-31 Juan Zuluaga-Gomez , Zeina Al Masry , Khaled Benaggoune , Safa Meraghni , Noureddine Zerhouni

Objective: The main objective of this study was to assess the diagnostic performances of an alert system integrated into the CPOE/EMR system for renally cleared drug dosing control. The generated alerts were compared with the daily routine…

Artificial Intelligence · Computer Science 2013-05-27 Boussadi Abdelali , Caruba Thibaut , Karras Alexandre , Berdot Sarah , Degoulet Patrice , Durieux Pierre , Sabatier Brigitte

Call Detail Record (CDR) datasets provide enough information about personal interactions to support building and analyzing detailed empirical social networks. We take one such dataset and describe the various ways of using it to create a…

Social and Information Networks · Computer Science 2019-07-18 Casey Doyle , Zala Herga , Stephen Dipple , Boleslaw K. Szymanski , Gyorgy Korniss , Dunja Mladenic

Machine learning, particularly convolutional neural networks (CNNs), has shown promise in medical image analysis, especially for thoracic disease detection using chest X-ray images. In this study, we evaluate various CNN architectures,…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Tejas Mirthipati

Following the recent adoption of deep neural networks (DNN) accross a wide range of applications, adversarial attacks against these models have proven to be an indisputable threat. Adversarial samples are crafted with a deliberate intention…

Machine Learning · Computer Science 2017-08-31 Valentina Zantedeschi , Maria-Irina Nicolae , Ambrish Rawat

How do we know if a particular medical treatment actually works? Ideally one would consult all available evidence from relevant clinical trials. Unfortunately, such results are primarily disseminated in natural language scientific articles,…

Computation and Language · Computer Science 2019-04-08 Eric Lehman , Jay DeYoung , Regina Barzilay , Byron C. Wallace

Observational studies are regarded as economic alternatives to randomized trials, often used in their stead to investigate and determine treatment efficacy. Due to lack of sample size, observational studies commonly combine data from…

Machine Learning · Statistics 2022-05-16 Tianhui Zhou , William E. Carson , Michael Hunter Klein , David Carlson

Adverse reaction caused by drugs is a potentially dangerous problem which may lead to mortality and morbidity in patients. Adverse Drug Event (ADE) extraction is a significant problem in biomedical research. We model ADE extraction as a…

Computation and Language · Computer Science 2018-01-03 Suriyadeepan Ramamoorthy , Selvakumar Murugan

Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting cancer drug responses (CDR),…

Quantitative Methods · Quantitative Biology 2023-11-22 Xiaoqiong Xia , Chaoyu Zhu , Yuqi Shan , Fan Zhong , Lei Liu

We present a machine learning-based anomaly detection product, AI Detect and Respond (AIDR), that monitors Walmart's business and system health in real-time. During the validation over 3 months, the product served predictions from over 3000…

Controlled drug delivery (CDD), the controlled release and delivery of therapeutic drugs inside the human body, is a promising approach to increase the efficacy of drug administration and reduce harmful side effects to the body. CDD has…

Signal Processing · Electrical Eng. & Systems 2023-05-11 Sebastian Lotter , Tom Bellmann , Sophie Marx , Mara Wesinger , Lukas Brand , Maximilian Schäfer , Dagmar Fischer , Robert Schober

The chest X-rays (CXRs) is one of the views most commonly ordered by radiologists (NHS),which is critical for diagnosis of many different thoracic diseases. Accurately detecting thepresence of multiple diseases from CXRs is still a…

Computer Vision and Pattern Recognition · Computer Science 2020-05-27 Hieu H. Pham , Tung T. Le , Dat T. Ngo , Dat Q. Tran , Ha Q. Nguyen

Drug-Drug Interactions (DDIs) may hamper the functionalities of drugs, and in the worst scenario, they may lead to adverse drug reactions (ADRs). Predicting all DDIs is a challenging and critical problem. Most existing computational models…

Quantitative Methods · Quantitative Biology 2023-04-19 Khaled Mohammed Saifuddin , Briana Bumgardner , Farhan Tanvir , Esra Akbas

Design rule checking (DRC) is getting increasingly complex in advanced nodes technologies. It would be highly desirable to have a fast interactive DRC engine that could be used during layout. In this work, we establish the proof of…

Purpose: To explore whether comments could be used as an assistant tool for heuristic decision-making, especially in cases where missing, incomplete, uncertain, or even incorrect evidence is acquired. Methods: Six COVID-19 drug candidates…

Information Retrieval · Computer Science 2021-12-22 Shuang Wang , Jian Du

We present an operational component of a real-world patient triage system. Given a specific patient presentation, the system is able to assess the level of medical urgency and issue the most appropriate recommendation in terms of best point…

Computation and Language · Computer Science 2018-10-01 Ivan Girardi , Pengfei Ji , An-phi Nguyen , Nora Hollenstein , Adam Ivankay , Lorenz Kuhn , Chiara Marchiori , Ce Zhang

In this study we propose a novel method to successfully detect the ADRs using feature matrix and feature selection. A feature matrix, which characterizes the medical events before patients take drugs or after patients take drugs, is created…

Computational Engineering, Finance, and Science · Computer Science 2016-11-17 Yihui Liu , Uwe Aickelin

Semiparametric efficient estimation of various multi-valued causal effects, including quantile treatment effects, is important in economic, biomedical, and other social sciences. Under the unconfoundedness condition, adjustment for…

Methodology · Statistics 2023-11-20 Xiaohong Chen , Ying Liu , Shujie Ma , Zheng Zhang

Minimizing adverse reactions caused by drug-drug interactions has always been a momentous research topic in clinical pharmacology. Detecting all possible interactions through clinical studies before a drug is released to the market is a…

Artificial Intelligence · Computer Science 2018-03-13 Meng Wang