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Time-to-event endpoints are central to evaluate treatment efficacy across many disease areas. Many trial protocols include interim analyses within group-sequential designs that control type I error via spending functions or boundary…

Methodology · Statistics 2026-01-19 Edoardo Ratti , Federico L. Perlino , Stefania Galimberti , Maria G. Valsecchi

As a person learns a new skill, distinct synapses, brain regions, and circuits are engaged and change over time. In this paper, we develop methods to examine patterns of correlated activity across a large set of brain regions. Our goal is…

Neurons and Cognition · Quantitative Biology 2013-10-31 Danielle S. Bassett , Nicholas F. Wymbs , M. Puck Rombach , Mason A. Porter , Peter J. Mucha , Scott T. Grafton

Human close-range proximity interactions are the key determinant for spreading processes like knowledge diffusion, norm adoption, and infectious disease transmission. These dynamical processes can be modeled with time-respecting paths on…

Physics and Society · Physics 2026-05-28 Silvia Guerrini , Ciro Cattuto , Lorenzo Dall'Amico

Transformer models systematically favor certain token positions, yet the architectural origins of this position bias remain poorly understood. This bias is closely connected to the Lost-in-the-Middle phenomenon, where models underutilize…

Machine Learning · Computer Science 2026-05-28 Hanna Herasimchyk , Robin Labryga , Tomislav Prusina , Sören Laue

The ability to accurately predict the surrounding environment is a foundational principle of intelligence in biological and artificial agents. In recent years, a variety of approaches have been proposed for learning to predict the physical…

Computer Vision and Pattern Recognition · Computer Science 2019-08-01 Alberto Cenzato , Alberto Testolin , Marco Zorzi

Recent studies have shown that synaptic unreliability is a robust and sufficient mechanism for inducing the stochasticity observed in cortex. Here, we introduce Synaptic Sampling Machines, a class of neural network models that uses synaptic…

Neural and Evolutionary Computing · Computer Science 2016-12-16 Emre O. Neftci , Bruno U. Pedroni , Siddharth Joshi , Maruan Al-Shedivat , Gert Cauwenberghs

Many recent generative models make use of neural networks to transform the probability distribution of a simple low-dimensional noise process into the complex distribution of the data. This raises the question of whether biological networks…

Neural and Evolutionary Computing · Computer Science 2018-02-07 Hesham Mostafa , Gert Cauwenberghs

Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…

Neurons and Cognition · Quantitative Biology 2019-08-12 Teresa M. Karrer , Jason Z. Kim , Jennifer Stiso , Ari E. Kahn , Fabio Pasqualetti , Ute Habel , Danielle S. Bassett

Working memory is a promising paradigm for assessing cognitive ergonomics of brain states in brain-computer interfaces(BCIs). This study decodes these states with a focus on environmental illumination effects via two distinct working memory…

Neurons and Cognition · Quantitative Biology 2025-12-22 Jiajia Li , Tian Guo , Fan Li , Huichao Ding , Guozheng Xu , Jian Song

In modern recommendation systems, the standard pipeline involves training machine learning models on historical data to predict user behaviors and improve recommendations continuously. However, these data training loops can introduce…

Methodology · Statistics 2024-04-08 Nian Si

Understanding the temporal dynamics of functional brain connectivity is important for addressing various questions in network neuroscience, such as how connectivity affects cognition and changes with disease. A fundamental challenge is to…

Methodology · Statistics 2025-12-02 Hester Huijsdens , Linda Geerligs , Max Hinne

In the mammalian brain newly acquired memories depend on the hippocampus for maintenance and recall, but over time these functions are taken over by the neocortex through a process called systems consolidation. However, reactivation of a…

Neurons and Cognition · Quantitative Biology 2019-03-29 Peter Helfer , Thomas R. Shultz

The recycling of contrastive language-image pre-trained (CLIP) models as backbones for a large number of downstream tasks calls for a thorough analysis of their transferability implications, especially their well-documented reproduction of…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Ryan Ramos , Yusuke Hirota , Yuta Nakashima , Noa Garcia

Many physical phenomena are modeled as stochastic searchers looking for targets. In these models, the probability that a searcher finds a particular target, its so-called hitting probability, is often of considerable interest. In this work…

Statistical Mechanics · Physics 2024-07-18 Samantha Linn , Sean D. Lawley

Causal effect estimation under networked interference is an important but challenging problem. Available parametric methods are limited in their model space, while previous semiparametric methods, e.g., leveraging neural networks to fit…

Machine Learning · Computer Science 2025-02-27 Weilin Chen , Ruichu Cai , Zeqin Yang , Jie Qiao , Yuguang Yan , Zijian Li , Zhifeng Hao

Spiking networks that perform probabilistic inference have been proposed both as models of cortical computation and as candidates for solving problems in machine learning. However, the evidence for spike-based computation being in any way…

Neural and Evolutionary Computing · Computer Science 2017-10-12 Luziwei Leng , Roman Martel , Oliver Breitwieser , Ilja Bytschok , Walter Senn , Johannes Schemmel , Karlheinz Meier , Mihai A. Petrovici

Present bias, the tendency to weigh costs and benefits incurred in the present too heavily, is one of the most widespread human behavioral biases. It has also been the subject of extensive study in the behavioral economics literature. While…

Computer Science and Game Theory · Computer Science 2016-03-29 Jon Kleinberg , Sigal Oren , Manish Raghavan

Short-term synaptic plasticity (STP) is often regarded as a presynaptic filter of spikes, independent of postsynaptic activity. Recent experiments, however, indicate an associative STP that depends on pre- and postsynaptic coactivation. We…

Neurons and Cognition · Quantitative Biology 2026-05-20 Genki Shimizu , Taro Toyoizumi

We introduce a new family of toy problems that combine features of linear-regression-style continuous in-context learning (ICL) with discrete associative recall. We pretrain transformer models on sample traces from this toy, specifically…

Machine Learning · Computer Science 2025-07-03 Sultan Daniels , Dylan Davis , Dhruv Gautam , Wentinn Liao , Gireeja Ranade , Anant Sahai

The plasticity of the conduction delay between neurons plays a fundamental role in learning. However, the exact underlying mechanisms in the brain for this modulation is still an open problem. Understanding the precise adjustment of…

Neural and Evolutionary Computing · Computer Science 2020-11-19 Alireza Nadafian , Mohammad Ganjtabesh