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Deep brain stimulation (DBS) is a neurosurgical procedure successfully used to treat conditions such as Parkinson's disease. Electrostimulation, carried out by implanting electrodes into an identified focus in the brain, makes it possible…

Signal Processing · Electrical Eng. & Systems 2023-08-23 Arkadiusz Nowacki , Ewelina Kołpa , Mateusz Szychiewicz , Konrad Ciecierski

Deep brain stimulation (DBS) is an advanced surgical treatment for the symptoms of Parkinson's disease (PD), involving electrical stimulation of neurons within the basal ganglia region of the brain. DBS is traditionally delivered in an…

Systems and Control · Electrical Eng. & Systems 2025-06-19 Cédric Join , Jakub Orłowski , Antoine Chaillet , Madeleine Lowery , Hugues Mounier , Michel Fliess

Deep brain stimulation (DBS) is an effective therapy as an alternative to pharmaceutical treatments for Parkinson's disease (PD). Aside from factors such as instrumentation, treatment plans, and surgical protocols, the success of the…

Image and Video Processing · Electrical Eng. & Systems 2024-10-30 Yiming Xiao , Jonathan C. Lau , Dimuthu Hemachandra , Greydon Gilmore , Ali R. Khan , Terry M. Peters

Deep Brain Stimulation (DBS) stands as an effective intervention for alleviating the motor symptoms of Parkinson's disease (PD). Traditional commercial DBS devices are only able to deliver fixed-frequency periodic pulses to the basal…

Machine Learning · Computer Science 2024-03-12 Hao-Lun Hsu , Qitong Gao , Miroslav Pajic

Epilepsy is the fourth most common neurological disorder and affects people of all ages worldwide. Deep Brain Stimulation (DBS) has emerged as an alternative treatment option when anti-epileptic drugs or resective surgery cannot lead to…

Image and Video Processing · Electrical Eng. & Systems 2022-01-27 Han Liu , Kathryn L. Holloway , Dario J. Englot , Benoit M. Dawant

Deep Brain Stimulation (DBS) is one of the most successful methods to diminish late-stage Parkinson's Disease (PD) symptoms. It is a delicate surgical procedure which requires detailed pre-surgical patient's study. High-field Magnetic…

Image and Video Processing · Electrical Eng. & Systems 2024-07-23 Tomás Lima , Igor Varga , Eduard Bakštein , Daniel Novák , Victor Alves

Deep Brain Stimulation (DBS) is a highly effective treatment for Parkinson's Disease (PD). Recent research uses reinforcement learning (RL) for DBS, with RL agents modulating the stimulation frequency and amplitude. But, these models rely…

Machine Learning · Computer Science 2025-10-07 Nicholas Carter , Arkaprava Gupta , Prateek Ganguli , Benedikt Dietrich , Vibhor Krishna , Samarjit Chakraborty

We present a nonlinear data-driven Model Predictive Control (MPC) algorithm for deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD). Although DBS is typically implemented in open-loop, closed-loop DBS (CLDBS) uses the…

Optimization and Control · Mathematics 2025-09-09 Sebastian Steffen , Mark Cannon

Adaptive deep brain stimulation (aDBS) has emerged as a promising treatment for Parkinson disease (PD). In aDBS, a surgically placed electrode sends dynamically altered stimuli to the brain based on neurophysiological feedback: an invasive…

Neurons and Cognition · Quantitative Biology 2025-05-16 Ekaterina Kuzmina , Dmitrii Kriukov , Mikhail Lebedev , Dmitry V. Dylov

Accurate assessment of Parkinsonian tremor is vital for monitoring disease progression and evaluating treatment efficacy. We introduce a pixel-based deep learning model designed to analyse postural tremor in Parkinson's disease (PD) from…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Felipe Duque-Quiceno , Grzegorz Sarapata , Yuriy Dushin , Miles Allen , Jonathan O'Keeffe

Deep brain stimulation (DBS) is a surgical treatment for Parkinson's Disease. Static models based on quasi-static approximation are common approaches for DBS modeling. While this simplification has been validated for bioelectric sources,…

Neurons and Cognition · Quantitative Biology 2016-08-18 Pablo A. Alvarado , Mauricio A. Álvarez , Álvaro A. Orozco

Deep-Brain Stimulation (DBS) is a therapy used in conjunction with medication to help alleviate the motor symptoms of Parkinson's Disease (PD). However, the monitoring and adjustment of DBS settings is tedious and expensive, requiring long…

Neurons and Cognition · Quantitative Biology 2019-12-03 Huy Phi , Sanjeev Janarthanan , Larry Zhang , Reza Hosseini Ghomi

Deep brain stimulation (DBS) can alleviate the movement disorders like Parkinson's disease (PD). Indeed, it is known that aberrant beta (13-30Hz)oscillations and the loss of dopaminergic neurons in the basal ganglia-thalamus (BGTH) and…

Neurons and Cognition · Quantitative Biology 2021-12-07 Hina Shaheen , Roderick Melnik

Deep brain stimulation (DBS) has the potential to improve the quality of life of people with a variety of neurological diseases. A key challenge in DBS is in the placement of a stimulation electrode in the anatomical location that maximizes…

Computer Vision and Pattern Recognition · Computer Science 2018-11-27 Camilo Bermudez , William Rodriguez , Yuankai Huo , Allison E. Hainline , Rui Li , Robert Shults , Pierre D. DHaese , Peter E. Konrad , Benoit M. Dawant , Bennett A. Landman

Deep Brain Stimulation (DBS) is a well-established neurosurgical treatment aiming at symptom alleviation in a range of neurological and psychiatric diseases. Computational models of DBS are widely used to investigate the effects of…

Systems and Control · Electrical Eng. & Systems 2025-11-17 Anna Franziska Frigge , Alexander Medvedev

This paper presents the results of our recent work on studying the effects of deep brain stimulation (DBS) and medication on the dynamics of brain local field potential (LFP) signals used for behavior analysis of patients with Parkinson s…

Neurons and Cognition · Quantitative Biology 2018-04-11 Hosein M. Golshan , Adam O. Hebb , Joshua Nedrud , Mohammad H. Mahoor

The study involved 56 patients with advanced and late stages of Parkinsons disease, which could be considered as potentially requiring neurosurgical treatment-electrical stimulation of deep brain structures. An algorithm has been developed…

Neurons and Cognition · Quantitative Biology 2021-11-10 Elcin Huseyn

In the world, about 7 to 10 million elderly people are suffering from Parkinson's Disease (PD) disease. Parkinson's disease is a common neurological degenerative disease, and its clinical characteristics are Tremors, rigidity, bradykinesia,…

Computer Vision and Pattern Recognition · Computer Science 2020-08-07 Elcin Huseyn

A large scale computational model of the basal ganglia (BG) network is proposed to describes movement disorder including deep brain stimulation (DBS). The model of this complex network considers four areas of the basal ganglia network: the…

Neurons and Cognition · Quantitative Biology 2021-03-15 Konstantinos Spiliotis , Jens Starke , Denise Franz , Angelika Richter , Rüdiger Köhling

Accurate intraoperative localization of the subthalamic nucleus (STN) is essential for the efficacy of Deep Brain Stimulation (DBS) in patients with Parkinson's disease. While microelectrode recordings (MERs) provide rich…

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