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Epilepsy is common neurological diseases, affecting about 0.6-0.8 % of world population. Epileptic patients suffer from chronic unprovoked seizures, which can result in broad spectrum of debilitating medical and social consequences. Since…

Quantitative Methods · Quantitative Biology 2017-06-13 Sachin S. Talathi

Severe sepsis and septic shock are conditions that affect millions of patients and have close to 50% mortality rate. Early identification of at-risk patients significantly improves outcomes. Electronic surveillance tools have been developed…

Computers and Society · Computer Science 2018-09-12 Emilia Apostolova , Tom Velez

Sepsis is a potentially life threatening inflammatory response to infection or severe tissue damage. It has a highly variable clinical course, requiring constant monitoring of the patient's state to guide the management of intravenous…

Machine Learning · Computer Science 2022-02-21 Thesath Nanayakkara , Gilles Clermont , Christopher James Langmead , David Swigon

Modern health care systems are conducting continuous, automated surveillance of the electronic medical record (EMR) to identify adverse events with increasing frequency; however, many events such as sepsis do not have elucidated prodromes…

Applications · Statistics 2023-05-24 Song Wei , Yao Xie , Christopher S. Josef , Rishikesan Kamaleswaran

Early management and better clinical outcomes for epileptic patients depend on seizure prediction. The accuracy and false alarm rates of existing systems are often compromised by their dependence on static thresholds and basic…

Signal Processing · Electrical Eng. & Systems 2025-01-29 Mathan Kumar Mounagurusamy , Thiyagarajan V S , Abdur Rahman , Shravan Chandak , D. Balaji , Venkateswara Rao Jallepalli

Sepsis is a life-threatening and serious global health issue. This study combines knowledge with available hospital data to investigate the potential causes of Sepsis that can be affected by policy decisions. We investigate the underlying…

Machine Learning · Computer Science 2025-02-19 Bruno Petrungaro , Neville K. Kitson , Anthony C. Constantinou

Sepsis is a life-threatening organ malfunction caused by the host's inability to fight infection, which can lead to death without proper and immediate treatment. Therefore, early diagnosis and medical treatment of sepsis in critically ill…

Machine Learning · Computer Science 2023-04-14 Kevin Ewig , Xiangwen Lin , Tucker Stewart , Katherine Stern , Grant O'Keefe , Ankur Teredesai , Juhua Hu

Sepsis is a syndrome that develops in the body in response to the presence of an infection. Characterized by severe organ dysfunction, sepsis is one of the leading causes of mortality in Intensive Care Units (ICUs) worldwide. These…

Machine Learning · Computer Science 2023-11-20 Tucker Stewart , Katherine Stern , Grant O'Keefe , Ankur Teredesai , Juhua Hu

Epileptic seizure forecasting, combined with the delivery of preventative therapies, holds the potential to greatly improve the quality of life for epilepsy patients and their caregivers. Forecasting seizures could prevent some potentially…

Signal Processing · Electrical Eng. & Systems 2020-05-18 Nhan Duy Truong , Yikai Yang , Christina Maher , Armin Nikpour , Omid Kavehei

Sepsis remains one of the most complex and heterogeneous syndromes in intensive care, characterized by diverse physiological trajectories and variable responses to treatment. While deep learning models perform well in the early prediction…

Machine Learning · Computer Science 2026-04-01 Vincent Lemaire , Nédra Meloulli , Pierre Jaquet

This study proposes the use of Machine Learning models to predict the early onset of sepsis using deidentified clinical data from Montefiore Medical Center in Bronx, NY, USA. A supervised learning approach was adopted, wherein an XGBoost…

We study multiple rule-based and machine learning (ML) models for sepsis detection. We report the first neural network detection and prediction results on three categories of sepsis. We have used the retrospective Medical Information Mart…

Machine Learning · Computer Science 2019-03-07 Avijit Mitra , Khalid Ashraf

The Gaussian-radial-basis function neural network (GRBFNN) has been a popular choice for interpolation and classification. However, it is computationally intensive when the dimension of the input vector is high. To address this issue, we…

Machine Learning · Computer Science 2023-08-15 Siyuan Xing , Jianqiao Sun

Despite decades of clinical research, sepsis remains a global public health crisis with high mortality, and morbidity. Currently, when sepsis is detected and the underlying pathogen is identified, organ damage may have already progressed to…

The disease trajectory for clinical sepsis, in terms of temporal cytokine and phenotypic dynamics, can be interpreted as a random dynamical system. The ability to make accurate predictions about patient state from clinical measurements has…

Quantitative Methods · Quantitative Biology 2020-07-30 Dale Larie , Gary An , Chase Cockrell

Reinforcement learning (RL) is a promising approach to generate treatment policies for sepsis patients in intensive care. While retrospective evaluation metrics show decreased mortality when these policies are followed, studies with…

Machine Learning · Computer Science 2024-04-11 Unnseo Park , Venkatesh Sivaraman , Adam Perer

Sepsis is a life-threatening condition caused by the body's response to an infection. In order to treat patients with sepsis, physicians must control varying dosages of various antibiotics, fluids, and vasopressors based on a large number…

Machine Learning · Computer Science 2019-12-17 Amirhossein Kiani , Chris Wang , Angela Xu

Although timely sepsis diagnosis and prompt interventions in Intensive Care Unit (ICU) patients are associated with reduced mortality, early clinical recognition is frequently impeded by non-specific signs of infection and failure to detect…

Machine Learning · Computer Science 2018-06-28 Tony Wang , Tom Velez , Emilia Apostolova , Tim Tschampel , Thuy L. Ngo , Joy Hardison

Checklists, while being only recently introduced in the medical domain, have become highly popular in daily clinical practice due to their combined effectiveness and great interpretability. Checklists are usually designed by expert…

Machine Learning · Computer Science 2022-11-15 Yukti Makhija , Edward De Brouwer , Rahul G. Krishnan

Sepsis remains a critical challenge due to its high mortality and complex prognosis. To address data limitations in studying MSSA sepsis, we extend existing transfer learning frameworks to accommodate transformation models for…

Applications · Statistics 2025-04-16 Nan Qiao , Haowei Jiang , Cunjie Lin