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We find a reentrant columnar-to-squamous rigidity transition in 3D epithelia, governed by volume- and area elasticity. Our framework maps onto the classic 2D Area- and Perimeter-Elasticity model but, unlike its 2D counterpart, exhibits both…

Soft Condensed Matter · Physics 2025-12-15 Tanmoy Sarkar , Matej Krajnc

In biological tissues, it is now well-understood that mechanical cues are a powerful mechanism for pattern regulation. While much work has focused on interactions between cells and external substrates, recent experiments suggest that cell…

Soft Condensed Matter · Physics 2017-11-01 Michael Czajkowski , Dapeng Bi , M. Lisa Manning , M. Cristina Marchetti

Topological defects determine the collective properties of anisotropic materials. How their configurations are controlled is not well understood however, especially in 3D. In living matter moreover, 2D defects have been linked to biological…

Soft Condensed Matter · Physics 2025-05-20 Pamela C. Guruciaga , Takafumi Ichikawa , Steffen Plunder , Takashi Hiiragi , Anna Erzberger

Active solids consume energy to allow for actuation, shape change, and wave propagation not possible in equilibrium. Whereas active interfaces have been realized across many experimental systems, control of three-dimensional (3D) bulk…

Soft Condensed Matter · Physics 2022-03-23 Jack Binysh , Thomas R. Wilks , Anton Souslov

We present a single, unified, multi-scale model to study the attachment\detachment dynamics of two deforming, near spherical cells, coated with binding ligands and subject to a slow, homogeneous shear flow in a viscous fluid medium. The…

Cell Behavior · Quantitative Biology 2015-04-23 Sarthok Sircar , Anthony J. Roberts

Most rigid formation controllers reported in the literature aim to only stabilize a rigid formation shape, while the formation orientation is not controlled. This paper studies the problem of controlling rigid formations with prescribed…

Systems and Control · Computer Science 2016-06-13 Zhiyong Sun , Myoung-Chul Park , Brian D. O. Anderson , Hyo-Sung Ahn

Soft solids and their surface deformations control the response of many natural and artificial systems. Yet, their underlying properties are vigorously debated, particularly for polymer networks. While molecular-scale theories predict no…

The rheological properties of biological tissues are core to processes such as cancer metastasis, wound healing and embryo development. The emergence of tissue and organ structures during morphogenesis requires the precise formation of…

Soft Condensed Matter · Physics 2026-03-10 Aidan J. Nicholas , Suzanne M. Fielding

We experimentally investigate the nature of 2D phase transitions in a quasi-2D granular fluid. Using a surface decorated with periodically spaced dimples we observe interfacial tension between coexisting liquid and crystal phases.…

Soft Condensed Matter · Physics 2022-01-05 J. G. Downs , N. D. Smith , K. K. Mandadapu , J. P. Garrahan , M. I. Smith

Vertex Models, as used to describe cellular tissue, have an energy controlled by deviations of each cell area and perimeter from target values. The constrained nonlinear relation between area and perimeter leads to new mechanical response.…

Soft Condensed Matter · Physics 2022-07-04 Arthur Hernandez , Michael F. Staddon , Mark J. Bowick , M. Cristina Marchetti , Michael Moshe

The mechanical properties of tissues play an essential role for all tissue properties such as cell division, and differentiation or morphogenesis. Here, we study theoretically the rheology of 2-dimensional epithelial tissues described by a…

Soft Condensed Matter · Physics 2023-12-18 Doron Grossman , Jean-Francois Joanny

Topological defects are crucial to the thermodynamics and structure of condensed matter systems. For instance, when incorporated into crystalline membranes like graphene, disclinations with positive and negative topological charge…

Soft Condensed Matter · Physics 2018-08-29 Isaac R. Bruss , Gregory M. Grason

The maintenance of tissue and organ structures during dynamic homeostasis is often not well understood. In order for a system to be stable, cell renewal, cell migration and cell death must be finely balanced. Moreover, a tissue's shape must…

Tissues and Organs · Quantitative Biology 2022-05-11 Domenic P. J. Germano , Stuart T. Johnston , Edmund J. Crampin , James M. Osborne

The cell cortex, a thin film of active material assembled below the cell membrane, plays a key role in cellular symmetry breaking processes such as cell polarity establishment and cell division. Here, we present a minimal model of the…

Biological Physics · Physics 2019-09-30 Alexander Mietke , V. Jemseena , K. Vijay Kumar , Ivo F. Sbalzarini , Frank Jülicher

Bending the edge of a thin elastic material promotes rigidity far from its clamped boundary. However, this curvature-induced rigidity can be overwhelmed by gravity or other external loading, resulting in elastic buckling and large…

Soft Condensed Matter · Physics 2025-04-16 Hanzhang Mao , Thomas G. J. Chandler , Mark Han , Saverio E. Spagnolie

The mechanics of a foam typically depends on the bubble geometry, topology, and the material at hand, be it metallic or polymeric, for example. While the foam energy functional for each bubble is typically minimization of surface area for a…

Soft Condensed Matter · Physics 2023-08-25 Kyungeun Kim , Tao Zhang , J. M. Schwarz

Surface roughness is a key factor when it comes to friction and wear, as well as to other physical properties. These phenomena are controlled by mechanisms acting at small scales, in which the topography of apparently-flat surfaces is…

Materials Science · Physics 2024-11-05 Joaquin Garcia-Suarez , Tobias Brink , Jean-François Molinari

In this paper, we present a 2D numerical model developed to simulate the dynamics of soft, deformable particles. To accommodate significant particle deformations, the particle surface is represented as a narrow shell composed of mass points…

Computational Physics · Physics 2025-04-01 Yohann Trivino , Vincent Richefeu , Farhang Radjai , Komlanvi Lampoh , Jean-Yves Delenne

To insight the relationships between the self-organizing structures of cells, such as the cell clusters, and the properties of biotissues is helpful in revealing the function and designing biomaterial. Traditional random foam model neglects…

Soft Condensed Matter · Physics 2017-06-07 Xiaohua Zhou , Erhu Zhang , Minggang Xia , Jianlin Liu , Shengli Zhang

When a thin sheet is crushed into a small three-dimensional volume, it invariably forms a structure with a low volume fraction but high resistance to further compression. Being a far-from-equilibrium process, forced crumpling is not…

Soft Condensed Matter · Physics 2012-03-28 Anne Dominique Cambou , Narayanan Menon