Related papers: Effects of electrical and optogenetic deep brain s…
The basal ganglia (BG) in the brain exhibit diverse functions for motor, cognition, and emotion. Such BG functions could be made via competitive harmony between the two competing pathways, direct pathway (DP) (facilitating movement) and…
Synchronized rhythmic oscillatory activity in the beta frequency band in the basal ganglia (BG) is a hallmark of Parkinson's disease (PD). Recent experiments and theoretical studies have demonstrated the crucial roles of T-type and L-type…
Neural oscillations are considered to be brain-specific signatures of information processing and communication in the brain. They also reflect pathological brain activity in neurological disorders, thus offering a basis for diagnoses and…
We present a quantitative study of phase entrainment by periodic visual stimuli in a biologically inspired neural network. The objective is to understand the neuronal population dynamics that underlie phase entrainment of brain oscillations…
Deep-Brain Stimulation (DBS) is a therapy used in conjunction with medication to help alleviate the motor symptoms of Parkinson's Disease (PD). However, the monitoring and adjustment of DBS settings is tedious and expensive, requiring long…
Synchronized oscillations in networks of inhibitory and excitatory coupled bursting neurons are common in a variety of neural systems from central pattern generators to human brain circuits. One example of the latter is the subcortical…
This work delves into studying the synchronization in two realistic neuron models using Hodgkin-Huxley dynamics. Unlike simplistic point-like models, excitatory synapses are here randomly distributed along the dendrites, introducing strong…
Optogenetics is an emerging field of neuroscience where neurons are genetically modified to express light-sensitive receptors that enable external control over when the neurons fire. Given the prominence of neuronal signaling within the…
Targeted electrical stimulation of the brain perturbs neural networks and modulates their rhythmic activity both at the site of stimulation and at remote brain regions. Understanding, or even predicting, this neuromodulatory effect is…
Computational methods have complemented experimental and clinical neursciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic…
Perceived outcomes from DBS for PD were sampled for 52 cases by surveying 46 DBS recipients and 45 carers. Post-DBS experience ranged from 10-129 months. There were significant variations in perceived outcomes over time. In some cases…
Biotechnology can benefit from dynamic control to improve production efficiency. In this context, optogenetics enables modulation of gene expression using light as an external input, allowing fine-tuning of protein levels to unlock dynamic…
Neuronal oscillations are closely related to the symptoms of Parkinson's disease (PD). In this study, we explore how random fluctuations (or "stochastic inputs") affect these oscillations in brain states, which reflect the collective…
Experimental data suggest that some classes of spiking neurons in the first layers of sensory systems are electrically coupled via gap junctions or ephaptic interactions. When the electrical coupling is removed, the response function…
The brain stimulation and its widespread use is one of the most important subjects in studies of neurophysiology. In brain electrical stimulation methods, following the surgery and electrode implantation, electrodes send electrical impulses…
Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing…
Parkinson's disease (PD) is a degenerative condition of the nervous system, which manifests itself primarily as muscle stiffness, hypokinesia, bradykinesia, and tremor. In patients suffering from advanced stages of PD, Deep Brain…
Neural networks have been employed for a wide range of processing applications like image processing, motor control, object detection and many others. Living neural networks offer advantages of lower power consumption, faster processing,…
Understanding how the brain integrates motor suppression with motivational processes remains a fundamental question in neuroscience. The rostral Pedunculopontine nucleus, a brainstem structure involved in motor control, has been shown to…
Nonlinear dynamics of spiking neural networks has recently attracted much interest as an approach to understand possible information processing in the brain and apply it to artificial intelligence. Since information can be processed by…