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In various neurological disorders spatio-temporal excitation patterns constitute examples of excitable behavior emerging from pathological pathways. During migraine, seizure, and stroke an initially localized pathological state can…

Pattern Formation and Solitons · Physics 2007-09-27 Markus A. Dahlem , Felix M. Schneider , Eckehard Schoell

In this paper we study noise-induced bistability in a specific circuit with many biological implications, namely a single-step enzymatic cycle described by Michaelis Menten equations with quasi-steady state assumption. We study the system…

Biological Physics · Physics 2011-07-25 Daniel Remondini , Enrico Giampieri , Armando Bazzani , Gastone Castellani , Amos Maritan

We consider spatially localized spiking activity patterns, so-called bumps, in ensembles of bistable spiking oscillators. The bistability consists in the coexistence of self-sustained spiking dynamics and quiescent steady-state regime. We…

Adaptation and Self-Organizing Systems · Physics 2023-08-16 Vladimir V. Semenov , Anna Zakharova

Cortical neurons are bistable; as a consequence their local field potentials can fluctuate between quiescent and active states, generating slow 0.5-2 Hz oscillations which are widely known as transitions between Up and Down States. Despite…

Disordered Systems and Neural Networks · Physics 2015-06-05 Jorge Hidalgo , Luis F. Seoane , Jesus M. Cortes , Miguel A. Munoz

We demonstrate that waves in distinct layers of a neuronal network can become phase-locked by common spatiotemporal noise. This phenomenon is studied for stationary bumps, traveling waves, and breathers. A weak noise expansion is used to…

Pattern Formation and Solitons · Physics 2015-04-22 Zachary P. Kilpatrick

We examine the effects of pure additive noise on spatially extended systems with quadratic nonlinearities. We develop a general multiscale theory for such systems and apply it to the Kuramoto-Sivashinsky equation as a case study. We first…

Statistical Mechanics · Physics 2012-09-20 M. Pradas , G. A. Pavliotis , S. Kalliadasis , D. T. Papageorgiou , D. Tseluiko

We present a simple analytical tool which gives an approximate insight into the stationary behavior of nonlinear systems undergoing the influence of a weak and rapid noise from one dominating source, e.g. the kinetic equations describing a…

Quantitative Methods · Quantitative Biology 2008-08-13 Anna Ochab-Marcinek

According to the conventional approach to model neural ensembles the extracellular environment has fixed ionic concentrations. However, in many cases the extracellular concentration of potassium ions can not be regarded as constant. That…

Disordered Systems and Neural Networks · Physics 2015-05-13 D. E. Postnov , F. Müller , R. B. Schuppner , L. Schimansky-Geier

We analyse the effect of intrinsic fluctuations on the properties of bistable stochastic systems with time scale separation operating under1 quasi-steady state conditions. We first formulate a stochastic generalisation of the quasi-steady…

Biological Physics · Physics 2016-03-02 Roberto de la Cruz , Pilar Guerrero , Fabian Spill , Tomás Alarcón

We present here some studies on noise-induced order and synchronous firing in a system of bidirectionally coupled generic type-I neurons. We find that transitions from unsynchronized to completely synchronized states occur beyond a critical…

Adaptation and Self-Organizing Systems · Physics 2015-06-22 Nishant Malik , B. Ashok , J. Balakrishnan

A recent study on the effect of colored driving noise on the escape from a metastable state derives an analytic expression of the transfer function of the leaky integrate-and-fire neuron model subject to colored noise. Here we present an…

Neurons and Cognition · Quantitative Biology 2015-10-14 Jannis Schuecker , Markus Diesmann , Moritz Helias

Epilepsy is one of the most common neurological disorders globally, affecting millions of individuals. Despite significant advancements, the precise mechanisms underlying this condition remain largely unknown, making accurately predicting…

Systems and Control · Electrical Eng. & Systems 2024-04-05 Yuzhen Qin , Ahmed El-Gazzar , Danielle S. Bassett , Fabio Pasqualetti , Marcel van Gerven

We measure the spectral densities of fluctuations of an underdamped nonlinear micromechanical oscillator. By applying a sufficiently large periodic excitation, two stable dynamical states are obtained within a particular range of driving…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 C. Stambaugh , H. B. Chan

In this article, we study the FitzHugh-Nagumo $(1,1)$--fast-slow system where the vector fields associated to the slow/fast equations come from the reduction of the Hodgin-Huxley model for the nerve impulse. After deriving dynamical…

Dynamical Systems · Mathematics 2025-06-19 Bruno F. F. Gonçalves , Isabel S. Labouriau , Alexandre A. P. Rodrigues

Subthreshold oscillations in neurons are those oscillations which do not attain the critical value of the membrane's voltage needed for triggering an action potential (a spike). Their contribution to the forming of action potentials in…

Dynamical Systems · Mathematics 2024-03-22 G. Moza , R. Efrem

The influence of time delay in systems of two coupled excitable neurons is studied in the framework of the FitzHugh-Nagumo model. Time-delay can occur in the coupling between neurons or in a self-feedback loop. The stochastic…

Pattern Formation and Solitons · Physics 2009-11-13 E. Schoell , G. Hiller , P. Hoevel , M. A. Dahlem

We study the stable phases of an attractor neural network model, with binary units, for hippocampal place cells encoding 1D or 2D spatial maps or environments. Using statistical mechanics tools we show that, below critical values for the…

Statistical Mechanics · Physics 2013-06-26 Rémi Monasson , Sophie Rosay

It has been proposed that neural noise in the cortex arises from chaotic dynamics in the balanced state: in this model of cortical dynamics, the excitatory and inhibitory inputs to each neuron approximately cancel, and activity is driven by…

Disordered Systems and Neural Networks · Physics 2017-04-28 Nimrod Shaham , Yoram Burak

A wave front and a wave back that spontaneously connect two hyperbolic equilibria, known as a heteroclinic wave loop, give rise to periodic waves with arbitrarily large spatial periods through the heteroclinic bifurcation. The nonlinear…

Analysis of PDEs · Mathematics 2025-03-28 Ji Li , Ke Wang , Qiliang Wu , Qing Yu

We study a network of spiking neurons with heterogeneous excitabilities connected via inhibitory delayed pulses. For globally coupled systems the increase of the inhibitory coupling reduces the number of firing neurons by following a Winner…

Disordered Systems and Neural Networks · Physics 2019-05-29 Stefano Luccioli , David Angulo Garcia , Alessandro Torcini