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Computational models of the cardiovascular system are increasingly used for the diagnosis, treatment, and prevention of cardiovascular disease. Before being used for translational applications, the predictive abilities of these models need…

Applications · Statistics 2024-01-11 Friederike Schäfer , Daniele E. Schiavazzi , Leif Rune Hellevik , Jacob Sturdy

Global sensitivity analysis of complex numerical models can be performed by calculating variance-based importance measures of the input variables, such as the Sobol indices. However, these techniques, requiring a large number of model…

Methodology · Statistics 2008-02-08 Amandine Marrel , Bertrand Iooss , Beatrice Laurent , Olivier Roustant

It is well-known that Sobol indices, which count among the most popular sensitivity indices, are based on the Sobol decomposition. Here we challenge this construction by redefining Sobol indices without the Sobol decomposition. In fact, we…

Machine Learning · Statistics 2026-03-23 Gildas Mazo

In modern engineering, physical processes are modelled and analysed using advanced computer simulations, such as finite element models. Furthermore, concepts of reliability analysis and robust design are becoming popular, hence, making…

Methodology · Statistics 2017-03-20 Roland Schöbi , Bruno Sudret

The global sensitivity analysis of a numerical model aims to quantify, by means of sensitivity indices estimate, the contributions of each uncertain input variable to the model output uncertainty. The so-called Sobol' indices, which are…

Statistics Theory · Mathematics 2019-11-26 Bertrand Iooss , Clémentine Prieur

The so-called polynomial chaos expansion is widely used in computer experiments. For example, it is a powerful tool to estimate Sobol' sensitivity indices. In this paper, we consider generalized chaos expansions built on general tensor…

Statistics Theory · Mathematics 2019-06-25 O Roustant , F. Gamboa , B Iooss

Global sensitivity analysis is a set of methods aiming at quantifying the contribution of an uncertain input parameter of the model (or combination of parameters) on the variability of the response. We consider here the estimation of the…

Statistics Theory · Mathematics 2020-01-22 Viet Chi Tran , Gwenaëlle Castellan , Anthony Cousien , Chi Tran

Biomechanical models often need to describe very complex systems, organs or diseases, and hence also include a large number of parameters. One of the attractive features of physics-based models is that in those models (most) parameters have…

Computational Engineering, Finance, and Science · Computer Science 2023-01-10 Barbara Wirthl , Sebastian Brandstaeter , Jonas Nitzler , Bernhard A. Schrefler , Wolfgang A. Wall

The Sobol' indices are a recognized tool in global sensitivity analysis. When the uncertain variables in a model are statistically independent, the Sobol' indices may be easily interpreted and utilized. However, their interpretation and…

Data Analysis, Statistics and Probability · Physics 2018-08-17 Joseph Hart , Pierre Gremaud

Sensitivity analysis (SA) is an important aspect of process automation. It often aims to identify the process inputs that influence the process output's variance significantly. Existing SA approaches typically consider the input-output…

Methodology · Statistics 2020-06-09 Zhanlin Liu , Ashis G. Banerjee , Youngjun Choe

Development of new multiscale mathematical models often entails considerable complexity and multiple undetermined parameters, typically arising from closure relations. To enable reliable simulations, one must quantify how uncertain physical…

Numerical Analysis · Mathematics 2026-02-26 Linheng Ruan , Ilja Kröker , Sergey Oladyshkin , Iryna Rybak

Every computer model depends on numerical input parameters that are chosen according to mostly conservative but rigorous numerical or empirical estimates. These parameters could for example be the step size for time integrators, a seed for…

Computational Physics · Physics 2020-09-11 Matthias Frey , Andreas Adelmann

This paper presents a method for performing Uncertainty Quantification in high-dimensional uncertain spaces by combining arbitrary polynomial chaos with a recently proposed scheme for sensitivity enhancement (1). Including available…

Numerical Analysis · Mathematics 2024-02-09 Nick Pepper , Francesco Montomoli , Kyriakos Kantarakias

Many mathematical models involve input parameters, which are not precisely known. Global sensitivity analysis aims to identify the parameters whose uncertainty has the largest impact on the variability of a quantity of interest (output of…

Statistics Theory · Mathematics 2013-03-27 Alexandre Janon , Thierry Klein , Agnes Lagnoux-Renaudie , Maëlle Nodet , Clémentine Prieur

We show how to apply Sobol's method of global sensitivity analysis to measure the influence exerted by a set of nodes' evidence on a quantity of interest expressed by a Bayesian network. Our method exploits the network structure so as to…

Machine Learning · Statistics 2021-10-11 Rafael Ballester-Ripoll , Manuele Leonelli

Sobol' sensitivity indices allow to quantify the respective effects of random input variables and their combinations on the variance of mathematical model output. We focus on the problem of Sobol' indices estimation via a metamodeling…

Statistics Theory · Mathematics 2021-01-07 Ivan I. Panin

Uncertainties exist in both physics-based and data-driven models. Variance-based sensitivity analysis characterizes how the variance of a model output is propagated from the model inputs. The Sobol index is one of the most widely used…

Methodology · Statistics 2020-06-09 Zhanlin Liu , Youngjun Choe

Many mathematical models involve input parameters, which are not precisely known. Global sensitivity analysis aims to identify the parameters whose uncertainty has the largest impact on the variability of a quantity of interest (output of…

Statistics Theory · Mathematics 2013-03-26 Alexandre Janon

Chaos expansions are widely used in global sensitivity analysis (GSA), as they leverage orthogonal bases of L2 spaces to efficiently compute Sobol' indices, particularly in data-scarce settings. When derivatives are available, we argue that…

Statistics Theory · Mathematics 2025-10-06 O Roustant , N Lüthen , D Heredia , B Sudret

Global sensitivity analysis of a numerical code, more specifically estimation of Sobol indices associated with input variables, generally requires a large number of model runs. When those demand too much computation time, it is necessary to…

Analysis of PDEs · Mathematics 2012-01-16 Alexandre Janon , Maëlle Nodet , Clémentine Prieur