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regulation largely unexplored, in part due to methodological limitations. Indeed, we review evidence demonstrating that commonly used methods, such as transcriptomics, are inadequate because the variability in mRNAs coding for ribosomal…

Quantitative Methods · Quantitative Biology 2020-09-01 Aleksandra A. Petelski , Nikolai Slavov

Molecular phenotyping is central in cancer precision medicine, but remains costly and standard methods only provide a tumour average profile. Microscopic morphological patterns observable in histopathology sections from tumours are…

Image and Video Processing · Electrical Eng. & Systems 2020-09-21 Yinxi Wang , Kimmo Kartasalo , Masi Valkonen , Christer Larsson , Pekka Ruusuvuori , Johan Hartman , Mattias Rantalainen

Flow matching has emerged as a simulation-free alternative to diffusion-based generative modeling, producing samples by solving an ODE whose time-dependent velocity field is learned along an interpolation between a simple source…

Machine Learning · Statistics 2026-04-10 Shivam Kumar , Yixin Wang , Lizhen Lin

Purpose: To achieve automatic hyperparameter estimation for the joint recovery of quantitative MR images, we propose a Bayesian formulation of the reconstruction problem that incorporates the signal model. Additionally, we investigate the…

Image and Video Processing · Electrical Eng. & Systems 2023-09-12 Shuai Huang , James J. Lah , Jason W. Allen , Deqiang Qiu

Modelling random dynamical systems in continuous time, diffusion processes are a powerful tool in many areas of science. Model parameters can be estimated from time-discretely observed processes using Markov chain Monte Carlo (MCMC) methods…

Computation · Statistics 2020-10-12 Susanne Pieschner , Christiane Fuchs

Sparsely activated transformers, such as Mixture of Experts (MoE), have received great interest due to their outrageous scaling capability which enables dramatical increases in model size without significant increases in computational cost.…

Machine Learning · Computer Science 2022-07-05 Rui Liu , Young Jin Kim , Alexandre Muzio , Hany Hassan Awadalla

Translation of proteins is a fundamental part of gene expression that is mediated by ribosomes. As ribosomes significantly contribute to both cellular mass and energy consumption, achieving efficient management of the ribosome population is…

Subcellular Processes · Quantitative Biology 2024-04-18 Clément Soubrier , Eric Foxall , Luca Ciandrini , Khanh Dao Duc

While stochastic geometry provides a powerful framework for the analysis of cellular networks, standard Monte Carlo simulations often suffer from slow convergence due to the stochasticity of the infinite far-field. This work introduces the…

Generative modeling provides a powerful framework for learning data distributions. These models initially relied on probabilistic methods such as Gaussian Processes (GP) for uncertainty-aware predictions and shifted towards larger trainable…

Residual networks, as discrete approximations of Ordinary Differential Equations (ODEs), have inspired significant advancements in neural network design, including multistep methods, high-order methods, and multi-particle dynamical systems.…

Computation and Language · Computer Science 2024-11-06 Bei Li , Tong Zheng , Rui Wang , Jiahao Liu , Qingyan Guo , Junliang Guo , Xu Tan , Tong Xiao , Jingbo Zhu , Jingang Wang , Xunliang Cai

Diffusion probabilistic models have shown impressive performance for speech enhancement, but they typically require 25 to 60 function evaluations in the inference phase, resulting in heavy computational complexity. Recently, a fine-tuning…

Audio and Speech Processing · Electrical Eng. & Systems 2025-08-12 Seonggyu Lee , Sein Cheong , Sangwook Han , Jong Won Shin

While the rheology of non-Brownian suspensions in the dilute regime is well-understood, their behavior in the dense limit remains mystifying. As the packing fraction of particles increases, particle motion becomes more collective, leading…

Soft Condensed Matter · Physics 2015-06-03 Edan Lerner , Gustavo Düring , Matthieu Wyart

We consider molecular communication networks consisting of transmitters and receivers distributed in a fluidic medium. In such networks, a transmitter sends one or more signalling molecules, which are diffused over the medium, to the…

Computational Engineering, Finance, and Science · Computer Science 2015-03-20 Chun Tung Chou

Flow matching has recently emerged as a principled framework for learning continuous-time transport maps, enabling efficient ODE-based sampling without relying on stochastic diffusion processes. While generative modeling has shown promise…

Computer Vision and Pattern Recognition · Computer Science 2026-05-08 Zhi Chen , Runze Hu , Le Zhang

Generating high-quality time-series data is challenging because real-world signals often exhibit multimodal patterns and multiscale dynamics, including oscillations and high-frequency variations. Flow Matching (FM) offers an efficient…

Machine Learning · Computer Science 2026-05-29 Junru Zhang , Lang Feng , Jinbo Wang , Xu Guo , Yucheng Wang , Han Yu , Min Wu , Yabo Dong , Duanqing Xu

We introduce a method for computing interfacial motions governed by curvature dependent acceleration. Our method is a thresholding algorithm of the BMO-type which, instead of utilizing a diffusion process, thresholds evolution by the wave…

Numerical Analysis · Mathematics 2015-05-11 Elliott Ginder , Karel Svadlenka

Modeling stochastic and irregularly sampled time series is a challenging problem found in a wide range of applications, especially in medicine. Neural stochastic differential equations (Neural SDEs) are an attractive modeling technique for…

Machine Learning · Computer Science 2025-02-05 Xi Zhang , Yuan Pu , Yuki Kawamura , Andrew Loza , Yoshua Bengio , Dennis L. Shung , Alexander Tong

An improved one-dimensional mathematical model based on Pulsed Flow Equations (PFE) is derived by integrating the axial component of the momentum equation over the transient Womersley velocity profile, providing a dynamic momentum equation…

Fluid Dynamics · Physics 2012-12-04 Omer San , Anne E. Staples

We develop a convergent reaction-drift-diffusion master equation (CRDDME) to facilitate the study of reaction processes in which spatial transport is influenced by drift due to one-body potential fields within general domain geometries. The…

Numerical Analysis · Mathematics 2025-01-22 Samuel A. Isaacson , Ying Zhang

The transition density of a diffusion process does not admit an explicit expression in general, which prevents the full maximum likelihood estimation (MLE) based on discretely observed sample paths. A\"{\i}t-Sahalia [J. Finance 54 (1999)…

Statistics Theory · Mathematics 2012-03-12 Jinyuan Chang , Song Xi Chen