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Related papers: Continuous State-Space Models for Optimal Sepsis T…

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From 2017 to 2018 the number of scientific publications found via PubMed search using the keyword "Machine Learning" increased by 46% (4,317 to 6,307). The results of studies involving machine learning, artificial intelligence (AI), and big…

Artificial Intelligence · Computer Science 2019-02-12 Russell Jeter , Christopher Josef , Supreeth Shashikumar , Shamim Nemati

Current machine learning models aiming to predict sepsis from Electronic Health Records (EHR) do not account for the heterogeneity of the condition, despite its emerging importance in prognosis and treatment. This work demonstrates the…

Quantitative Methods · Quantitative Biology 2020-11-24 Zina Ibrahim , Honghan Wu , Ahmed Hamoud , Lukas Stappen , Richard Dobson , Andrea Agarossi

The management of invasive mechanical ventilation, and the regulation of sedation and analgesia during ventilation, constitutes a major part of the care of patients admitted to intensive care units. Both prolonged dependence on mechanical…

Artificial Intelligence · Computer Science 2017-04-24 Niranjani Prasad , Li-Fang Cheng , Corey Chivers , Michael Draugelis , Barbara E Engelhardt

Sepsis is the leading cause of death in non-coronary intensive care units. Moreover, a delay of antibiotic treatment of patients with severe sepsis by only few hours is associated with increased mortality. This insight makes accurate models…

Quantitative Methods · Quantitative Biology 2019-09-26 Shigehiko Schamoni , Holger A. Lindner , Verena Schneider-Lindner , Manfred Thiel , Stefan Riezler

We present ICU-Sepsis, an environment that can be used in benchmarks for evaluating reinforcement learning (RL) algorithms. Sepsis management is a complex task that has been an important topic in applied RL research in recent years.…

Machine Learning · Computer Science 2025-03-12 Kartik Choudhary , Dhawal Gupta , Philip S. Thomas

With sepsis remaining a leading cause of mortality, early identification of patients with sepsis and those at high risk of death is a challenge of high socioeconomic importance. Given the potential of hyperspectral imaging (HSI) to monitor…

Objective: Sepsis is a life-threatening condition caused by severe infection leading to acute organ dysfunction. This study proposes a data-driven metric and a continuous reward function to optimize personalized heparin therapy in surgical…

Machine Learning · Computer Science 2025-12-15 Jiang Liu , Yujie Li , Chan Zhou , Yihao Xie , Qilong Sun , Xin Shu , Peiwei Li , Chunyong Yang , Yiziting Zhu , Jiaqi Zhu , Yuwen Chen , Bo An , Hao Wu , Bin Yi

Sepsis is a life-threatening and serious global health issue. This study combines knowledge with available hospital data to investigate the potential causes of Sepsis that can be affected by policy decisions. We investigate the underlying…

Machine Learning · Computer Science 2025-02-19 Bruno Petrungaro , Neville K. Kitson , Anthony C. Constantinou

Reinforcement learning (RL) is a promising approach to generate treatment policies for sepsis patients in intensive care. While retrospective evaluation metrics show decreased mortality when these policies are followed, studies with…

Machine Learning · Computer Science 2024-04-11 Unnseo Park , Venkatesh Sivaraman , Adam Perer

Sepsis is a severe condition responsible for many deaths in the United States and worldwide, making accurate prediction of outcomes crucial for timely and effective treatment. Previous studies employing machine learning faced limitations in…

Machine Learning · Computer Science 2025-01-03 Arseniy Shumilov , Yueting Zhu , Negin Ashrafi , Armin Abdollahi , Greg Placencia , Kamiar Alaei , Maryam Pishgar

We develop a deep learning approach to predicting a set of ventilator parameters for a mechanically ventilated septic patient using a long and short term memory (LSTM) recurrent neural network (RNN) model. We focus on short-term predictions…

Quantitative Methods · Quantitative Biology 2022-02-23 Zhijun Zeng , Zhen Hou , Ting Li , Lei Deng , Jianguo Hou , Xinran Huang , Jun Li , Meirou Sun , Yunhan Wang , Qiyu Wu , Wenhao Zheng , Hua Jiang , Qi Wang

Sepsis is a life-threatening medical emergency, which is a major cause of death worldwide and the second highest cause of mortality in the United States. Researching the optimal control treatment or intervention strategy on the…

Dynamical Systems · Mathematics 2022-01-11 Yuyang Chen , Kaiming Bi , Chih-Hang J. Wu , David Ben-Arieh , Ashesh Sinha

Sepsis is a life threatening condition that requires timely detection in intensive care settings. Traditional machine learning approaches, including Naive Bayes, Support Vector Machine (SVM), Random Forest, and XGBoost, often rely on manual…

Machine Learning · Computer Science 2025-09-03 Hejiang Cai , Di Wu , Ji Xu , Xiang Liu , Yiziting Zhu , Xin Shu , Yujie Li , Bin Yi

Continuous diagnosis and prognosis are essential for intensive care patients. It can provide more opportunities for timely treatment and rational resource allocation, especially for sepsis, a main cause of death in ICU, and COVID-19, a new…

Machine Learning · Computer Science 2022-10-07 Chenxi Sun , Hongyan Li , Moxian Song , Derun Cai , Baofeng Zhang , Shenda Hong

Sepsis is a life-threatening condition caused by the body's response to an infection. In order to treat patients with sepsis, physicians must control varying dosages of various antibiotics, fluids, and vasopressors based on a large number…

Machine Learning · Computer Science 2019-12-17 Amirhossein Kiani , Chris Wang , Angela Xu

Sepsis is a leading cause of death in the Intensive Care Units (ICU). Early detection of sepsis is critical for patient survival. In this paper, we propose a multimodal Transformer model for early sepsis prediction, using the physiological…

Machine Learning · Computer Science 2022-03-29 Yuqing Wang , Yun Zhao , Rachael Callcut , Linda Petzold

Sepsis, a life-threatening condition triggered by the body's exaggerated response to infection, demands urgent intervention to prevent severe complications. Existing machine learning methods for managing sepsis struggle in offline…

Machine Learning · Computer Science 2024-03-13 Dipesh Tamboli , Jiayu Chen , Kiran Pranesh Jotheeswaran , Denny Yu , Vaneet Aggarwal

Effective reinforcement learning (RL) for sepsis treatment depends on learning stable, clinically meaningful state representations from irregular ICU time series. While previous works have explored representation learning for this task, the…

Machine Learning · Computer Science 2025-12-29 Yue Gao

Sepsis remains one of the leading causes of mortality in intensive care units, where timely and accurate treatment decisions can significantly impact patient outcomes. In this work, we propose an interpretable decision support framework.…

Machine Learning · Computer Science 2026-01-21 Punit Kumar , Vaibhav Saran , Divyesh Patel , Nitin Kulkarni , Alina Vereshchaka

Sepsis is a life-threatening disease with high morbidity, mortality and healthcare costs. The early prediction and administration of antibiotics and intravenous fluids is considered crucial for the treatment of sepsis and can save…

Computation and Language · Computer Science 2021-07-26 Fred Qin , Vivek Madan , Ujjwal Ratan , Zohar Karnin , Vishaal Kapoor , Parminder Bhatia , Taha Kass-Hout