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Computational drug repositioning technology is an effective tool to accelerate drug development. Although this technique has been widely used and successful in recent decades, many existing models still suffer from multiple drawbacks such…

Machine Learning · Computer Science 2022-06-01 Xinxing Yang , Genke Yang , Jian Chu

Recommender systems are seen as an effective tool to address information overload, but it is widely known that the presence of various biases makes direct training on large-scale observational data result in sub-optimal prediction…

Information Retrieval · Computer Science 2023-04-19 Haoxuan Li , Yanghao Xiao , Chunyuan Zheng , Peng Wu

We propose rectified factor networks (RFNs) to efficiently construct very sparse, non-linear, high-dimensional representations of the input. RFN models identify rare and small events in the input, have a low interference between code units,…

Machine Learning · Computer Science 2018-01-31 Djork-Arné Clevert , Andreas Mayr , Thomas Unterthiner , Sepp Hochreiter

Generative information retrieval, encompassing two major tasks of Generative Document Retrieval (GDR) and Grounded Answer Generation (GAR), has gained significant attention in the area of information retrieval and natural language…

Information Retrieval · Computer Science 2023-12-19 Xiaoxi Li , Yujia Zhou , Zhicheng Dou

Penalized quantile regression (QR) is widely used for studying the relationship between a response variable and a set of predictors under data heterogeneity in high-dimensional settings. Compared to penalized least squares, scalable…

Methodology · Statistics 2022-05-06 Rebeka Man , Xiaoou Pan , Kean Ming Tan , Wen-Xin Zhou

Variational inference is increasingly being addressed with stochastic optimization. In this setting, the gradient's variance plays a crucial role in the optimization procedure, since high variance gradients lead to poor convergence. A…

Machine Learning · Computer Science 2020-10-23 Tomas Geffner , Justin Domke

Variational Autoencoders (VAEs) are expressive latent variable models that can be used to learn complex probability distributions from training data. However, the quality of the resulting model crucially relies on the expressiveness of the…

Machine Learning · Computer Science 2018-06-12 Lars Mescheder , Sebastian Nowozin , Andreas Geiger

Studying unified model averaging estimation for situations with complicated data structures, we propose a novel model averaging method based on cross-validation (MACV). MACV unifies a large class of new and existing model averaging…

Methodology · Statistics 2024-12-16 Dalei Yu , Xinyu Zhang , Hua Liang

We consider the problem of computing optimal linear control policies for linear systems in finite-horizon. The states and the inputs are required to remain inside pre-specified safety sets at all times despite unknown disturbances. In this…

Systems and Control · Computer Science 2019-12-17 Luca Furieri , Maryam Kamgarpour

The scaling of large language models to encode all the world's knowledge in model parameters is unsustainable and has exacerbated resource barriers. Retrieval-Augmented Generation (RAG) presents a potential solution, yet its application to…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Varun Nagaraj Rao , Siddharth Choudhary , Aditya Deshpande , Ravi Kumar Satzoda , Srikar Appalaraju

Despite its short history, Generative Adversarial Network (GAN) has been extensively studied and used for various tasks, including its original purpose, i.e., synthetic sample generation. However, applying GAN to different data types with…

Image and Video Processing · Electrical Eng. & Systems 2020-05-20 Minhyeok Lee , Junhee Seok

Recently-developed genotype imputation methods are a powerful tool for detecting untyped genetic variants that affect disease susceptibility in genetic association studies. However, existing imputation methods require individual-level…

Applications · Statistics 2010-11-15 Xiaoquan Wen , Matthew Stephens

An evolutionary form of a generalized Bayesian update method, which is strictly derivative- free yet directed through an additive update term based purely on the statistical moments of the design variables, is proposed for nonlinear inverse…

Methodology · Statistics 2013-12-17 M Venugopal , D Roy , R M Vasu

Variable selection has played a critical role in modern statistical learning and scientific discoveries. Numerous regularization and Bayesian variable selection methods have been developed in the past two decades for variable selection, but…

Methodology · Statistics 2024-03-04 Travis Canida , Hongjie Ke , Shuo Chen , Zhenayo Ye , Tianzhou Ma

Building on the success of deep learning, Generative Adversarial Networks (GANs) provide a modern approach to learn a probability distribution from observed samples. GANs are often formulated as a zero-sum game between two sets of…

Machine Learning · Computer Science 2020-09-28 Pirazh Khorramshahi , Hossein Souri , Rama Chellappa , Soheil Feizi

This paper studies a Markov network model for unbalanced data, aiming to solve the problems of classification bias and insufficient minority class recognition ability of traditional machine learning models in environments with uneven class…

Machine Learning · Computer Science 2025-02-06 Junliang Du , Shiyu Dou , Bohuan Yang , Jiacheng Hu , Tai An

Latent Variable Models (LVMs) are a large family of machine learning models providing a principled and effective way to extract underlying patterns, structure and knowledge from observed data. Due to the dramatic growth of volume and…

Machine Learning · Computer Science 2015-12-24 Pengtao Xie , Yuntian Deng , Eric Xing

Visual Anomaly Detection (VAD) aims to identify abnormal samples in images that deviate from normal patterns, covering multiple domains, including industrial, logical, and medical fields. Due to the domain gaps between these fields,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Zhaopeng Gu , Bingke Zhu , Guibo Zhu , Yingying Chen , Ming Tang , Jinqiao Wang

We propose a novel framework for incorporating unlabeled data into semi-supervised classification problems, where scenarios involving the minimization of either i) adversarially robust or ii) non-robust loss functions have been considered.…

Adaptive cubic regularization methods have emerged as a credible alternative to linesearch and trust-region for smooth nonconvex optimization, with optimal complexity amongst second-order methods. Here we consider a general/new class of…

Optimization and Control · Mathematics 2018-11-20 Coralia Cartis , Nicholas I. M. Gould , Philippe L. Toint