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Understanding the interactions between cells and the extracellular matrix (ECM) during collective cell invasion is crucial for advancements in tissue engineering, cancer therapies, and regenerative medicine. This study focuses on the roles…

Cell Behavior · Quantitative Biology 2025-10-02 Yuan Yin , Sarah L. Waters , Ruth E. Baker

The mechanical behaviour of solid biological tissues has long been described using models based on classical continuum mechanics. However, the classical continuum theories of elasticity and viscoelasticity cannot easily capture the…

Biological Physics · Physics 2017-05-16 Shakti N. Menon , Cameron L. Hall , Scott W. McCue , D. L. Sean McElwain

Finite mixture models are powerful tools for modelling and analyzing heterogeneous data. Parameter estimation is typically carried out using maximum likelihood estimation via the Expectation-Maximization (EM) algorithm. Recently, the…

Computation · Statistics 2020-05-15 Sharon X. Lee , Geoffrey J. McLachlan , Kaleb L. Leemaqz

Extreme weather is straining electricity systems, exposing the limitations of reactive responses, and prompting the need for proactive resilience planning. Most existing approaches to enhance electricity system resilience employ simplified…

Machine Learning · Computer Science 2025-10-03 Shuyi Chen , Shixiang Zhu , Ramteen Sioshansi

We employ the Partially Saturated Cells Method (PSM) to model the interaction between the fluid flow and solid moving objects as an extension to the conventional lattice Boltzmann method. We introduce an efficient and accurate method for…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-02-28 P. Suffa , S. Kemmler , H. Koestler , U. Ruede

Continuum solvation models are becoming increasingly relevant in condensed matter simulations, allowing to characterize materials interfaces in the presence of wet electrified environments at a reduced computational cost with respect to all…

Computational Physics · Physics 2023-08-16 Gabriel Medrano , Edan Bainglass , Oliviero Andreussi

Designing reconfigurable metasurfaces that can dynamically control scattered electromagnetic waves and work in the near-infrared (NIR) and optical regimes remains a challenging task, which is hindered by the static material property and…

In the mammalian brain, newly acquired memories depend on the hippocampus for maintenance and recall, but over time the neocortex takes over these functions, rendering memories hippocampus-independent. The process responsible for this…

Neurons and Cognition · Quantitative Biology 2021-07-02 Peter Helfer , Thomas R. Shultz

Human memory is inherently prone to forgetting. To address this, multimodal embedding models have been introduced, which transform diverse real-world data into a unified embedding space. These embeddings can be retrieved efficiently, aiding…

Information Retrieval · Computer Science 2024-09-25 Dongqi Cai , Shangguang Wang , Chen Peng , Zeling Zhang , Mengwei Xu

Biological membranes constitute boundaries of cells and cell organelles. Physico-chemical mechanisms at the atomic scale are dictated by protein-lipid interaction strength, lipid composition, lipid distribution in the vicinity of the…

Biological Physics · Physics 2015-10-19 N. Ramakrishnan , P. B. Sunil Kumar , Ravi Radhakrishnan

The rheology of biological tissue plays an important role in many processes, from organ formation to cancer invasion. Here, we use a multi-phase field model of motile cells to simulate active microrheology within a tissue monolayer. When…

Soft Condensed Matter · Physics 2022-10-12 Austin Hopkins , Michael Chiang , Benjamin Loewe , Davide Marenduzzo , M. Cristina Marchetti

The microscopic structure of a plant cell wall is given by cellulose microfibrils embedded in a cell wall matrix. In this paper we consider a microscopic model for interactions between viscoelastic deformations of a plant cell wall and…

Analysis of PDEs · Mathematics 2016-01-01 Mariya Ptashnyk , Brian Seguin

The Vertex Model for epithelia models the apical surface of the tissue by a tiling, with polygons representing cells and edges representing cell-cell junctions. The mechanics are described by an energy governed by deviations from a target…

Biological Physics · Physics 2024-10-10 Michael F. Staddon , Carl D. Modes

The circulatory system, comprising the heart and blood vessels, is vital for nutrient transport, waste removal, and homeostasis. Traditional computational models often treat cardiac electromechanics and blood flow dynamics separately,…

We present numerical experiments for geophysics electromagnetic (EM) modeling based upon high-order edge elements and supervised $h+p$ refinement approaches on massively parallel computers. Our high-order $h+p$ refinement strategy is based…

This paper proposes a novel neural-network-based adaptive hybrid-reflectance three-dimensional (3-D) surface reconstruction model. The neural network combines the diffuse and specular components into a hybrid model. The proposed model…

Neural and Evolutionary Computing · Computer Science 2009-12-14 Vincy Joseph , Shalini Bhatia

Real-time hierarchical energy-sharing markets are promising to coordinate large numbers of prosumers. Still, most existing clearing methods rely on linearized or DC power-flow models and do not explicitly handle reactive power or…

Optimization and Control · Mathematics 2026-05-25 Tonghua Liu , Yifan Su , Zhaojian Wang , Feng Liu

In electrochemical systems, the structure of electrical double layers (EDLs) near electrode surfaces is crucial for energy conversion and storage functions. While the electrodes in real-world systems are usually heterogeneous, to date the…

We propose a three dimensional mechanical model of embryonic tissue dynamics. Mechanically coupled adherent cells are represented as particles interconnected with elastic beams which can exert non-central forces and torques. Tissue…

Biological Physics · Physics 2015-06-22 Andras Czirok , Dona Greta Isai

Research in cell biology is steadily contributing new knowledge about many different aspects of physiological processes like polymerization, both with respect to the involved molecular structures as well as their related function.…

Human-Computer Interaction · Computer Science 2014-07-15 Ivan Kolesar , Julius Parulek , Ivan Viola , Stefan Bruckner , Anne-Kristin Stavrum , Helwig Hauser
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