Related papers: Layer dependent role of collagen recruitment durin…
During the progression of pulmonary fibrosis, initially isolated regions of high stiffness form and grow in the lung tissue due to collagen deposition by fibroblast cells. We have previously shown that ongoing collagen deposition may not…
The mechanical response of biological soft tissues is influenced by wall heterogeneity, including spatial variations in wall thickness. Traditional models for homogeneous soft tissues under uniaxial loading predict higher stretch and stress…
The high compliance of the urinary bladder during filling is essential for its proper function, enabling it to accommodate significant volumetric increases with minimal rise in transmural pressure. This study aimed to elucidate the physical…
Many of the cell membrane vital functions are achieved by the self-organization of the proteins and biopolymers embedded in it. The protein dynamics are in part determined by its drag. A large number of these proteins can polymerize to form…
The predominant structural protein in vertebrates is collagen, which plays a key role in extracellular matrix and connective tissue mechanics. Despite its prevalence and physical importance in biology, the mechanical properties of molecular…
Collagen is the key protein of connective tissue (i.e., skin, tendons and ligaments, cartilage, among others) accounting for 25% to 35% of the whole-body protein content, and entitled of conferring mechanical stability. This protein is also…
Collagen is the most abundant extracellular-network-forming protein in animal biology and is important in both natural and artificial tissues, where it serves as a material of great mechanical versatility. This versatility arises from its…
We address the folding induced by differential growth in soft layered solids via an elementary model that consists of a soft growing neo-Hookean elastic layer adhered to a deep elastic substrate. As the layer/substrate modulus ratio is…
We examine the phase transition of polymer adsorption as well as the underlying kinetics of polymer binding from dilute solutions on a structureless solid surface. The emphasis is put on the properties of regular multiblock copolymers,…
In solid tumors, cells constantly interact with the surrounding extracellular matrix. In particular cancer-associated fibroblasts modulate the architecture of the matrix by exerting forces and contracting collagen fibres, creating paths…
Collagen, a key structural component of the extracellular matrix, undergoes significant remodeling during carcinogenesis. However, the important role of collagen levels in breast cancer diagnostics still lacks effective in vivo detection…
Thin layers of elastomers bonded to two rigid plates demonstrate unusual failure response. Historically, it has been believed that strongly-bonded layers fail by two distinct mechanisms: (i) internal/external penny-shaped crack nucleation…
Bladder function is typically assessed through pressure volume relations, compliance indices and flow measurements, whereas structural evaluation relies largely on qualitative imaging findings. These approaches do not formally quantify how…
A quantitative understanding of how cells interact with their extracellular matrix via molecular bonds is fundamental for many important processes in cell biology and engineering. In these interactions, the deformability of cells and matrix…
Constancy of life vitally depends on the internalization of particles through biomembranes. Of particular interest, cellular uptake, including phagocytosis, receptor-mediated endocytosis, and membrane fusion, critically depends on the…
We present a reinforcement learning framework for quadrupedal wall-climbing locomotion that explicitly addresses uncertainty in magnetic foot adhesion. A physics-based adhesion model of a quadrupedal magnetic climbing robot is incorporated…
Biopolymer networks are common in biological systems from the cytoskeleton of individual cells to collagen in the extracellular matrix. The mechanics of these systems under applied strain can be explained in some cases by a phase transition…
Organisms in nature, such as Cephalopods and Pachyderms, exploit stiffness modulation to achieve amazing dexterity in the control of their appendages. In this paper, we explore the phenomenon of layer jamming, which is a popular stiffness…
Cells can sense and respond to mechanical signals over relatively long distances across fibrous extracellular matrices. Here, we explore all of the key factors that influence long range force transmission in cell-populated collagen…
Cartilage is a connective tissue that covers the surfaces of bones in joints and provides a smooth gliding surface for movement. It is characterized by specific biophysical properties that allow it to withstand compressive loads, distribute…