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Artificial intelligence (AI) holds great promise for supporting clinical trials, from patient recruitment and endpoint assessment to treatment response prediction. However, deploying AI without safeguards poses significant risks,…

Machine Learning · Computer Science 2025-10-09 Yao Chen , David Ohlssen , Aimee Readie , Gregory Ligozio , Ruvie Martin , Thibaud Coroller

Artificial intelligence (AI) systems have become increasingly popular in many areas. Nevertheless, AI technologies are still in their developing stages, and many issues need to be addressed. Among those, the reliability of AI systems needs…

Software Engineering · Computer Science 2021-11-11 Yili Hong , Jiayi Lian , Li Xu , Jie Min , Yueyao Wang , Laura J. Freeman , Xinwei Deng

Randomized experiments have been the gold standard for assessing the effectiveness of a treatment or policy. The classical complete randomization approach assigns treatments based on a prespecified probability and may lead to inefficient…

Methodology · Statistics 2023-10-26 Waverly Wei , Xinwei Ma , Jingshen Wang

A dynamic treatment regimen (DTR) is a pre-specified sequence of decision rules which maps baseline or time-varying measurements on an individual to a recommended intervention or set of interventions. Sequential multiple assignment…

Methodology · Statistics 2019-10-23 Brook Luers , Min Qian , Inbal Nahum-Shani , Connie Kasari , Daniel Almirall

Random testing (RT) is a well-studied testing method that has been widely applied to the testing of many applications, including embedded software systems, SQL database systems, and Android applications. Adaptive random testing (ART) aims…

Software Engineering · Computer Science 2020-07-15 Rubing Huang , Weifeng Sun , Yinyin Xu , Haibo Chen , Dave Towey , Xin Xia

The advancement of Large Language Models (LLMs) has significantly boosted performance in natural language processing (NLP) tasks. However, the deployment of high-performance LLMs incurs substantial costs, primarily due to the increased…

Machine Learning · Computer Science 2024-03-22 Saehan Jo , Immanuel Trummer

Testing whether a variable of interest affects the outcome is one of the most fundamental problem in statistics and is often the main scientific question of interest. To tackle this problem, the conditional randomization test (CRT) is…

Methodology · Statistics 2023-05-26 Dae Woong Ham , Jiaze Qiu

Adaptive designs have been proposed for clinical trials in which the nuisance parameters or alternative of interest are unknown or likely to be misspecified before the trial. Whereas most previous works on adaptive designs and mid-course…

Methodology · Statistics 2011-05-18 Jay Bartroff , Tze Leung Lai

An artificial intelligence (AI) model can be viewed as a function that maps inputs to outputs in high-dimensional spaces. Once designed and well trained, the AI model is applied for inference. However, even optimized AI models can produce…

Artificial Intelligence · Computer Science 2026-02-27 Sha Hu

This paper explores the use of Artificial Intelligence (AI) as a tool for diagnosis, assessment, and intervention for individuals with Autism Spectrum Disorder (ASD). It focuses particularly on AI's role in early diagnosis, utilizing…

Artificial Intelligence · Computer Science 2025-05-06 Aggeliki Sideraki , Christos-Nikolaos Anagnostopoulos

The applications of Artificial Intelligence (AI) surround decisions on increasingly many aspects of human lives. Society responds by imposing legal and social expectations for the accountability of such automated decision systems (ADSs).…

Machine Learning · Computer Science 2022-08-18 Furkan Gursoy , Ioannis A. Kakadiaris

Organizations increasingly adopt AI technologies to accelerate their performance and capacity to adapt to market dynamics. This study examines how organizations implement AI in experimental methodologies such as growth hacking, lean…

Computers and Society · Computer Science 2026-03-24 Parisa Omidmand , Saeid Ataei

Self-supervised pretraining has been extensively studied in language and vision domains, where a unified model can be easily adapted to various downstream tasks by pretraining representations without explicit labels. When it comes to…

Machine Learning · Computer Science 2023-01-25 Yanchao Sun , Shuang Ma , Ratnesh Madaan , Rogerio Bonatti , Furong Huang , Ashish Kapoor

Screening patients for clinical trial eligibility remains a manual, time-consuming, and resource-intensive process. We present a secure, scalable proof-of-concept system for Artificial Intelligence (AI)-augmented patient-trial matching that…

Machine learning (ML) models are increasingly used to support clinical decision-making. However, real-world medical datasets are often noisy, incomplete, and imbalanced, leading to performance disparities across patient subgroups. These…

One of the most challenging problems facing NLP today is evaluation. Some of the most pressing issues pertain to benchmark saturation, data contamination, and diversity in the quality of test examples. To address these concerns, we propose…

Computation and Language · Computer Science 2025-02-12 Vipul Gupta , Candace Ross , David Pantoja , Rebecca J. Passonneau , Megan Ung , Adina Williams

One of the main goals of sequential, multiple assignment, randomized trials (SMART) is to find the most efficacious design embedded dynamic treatment regimes. The analysis method known as multiple comparisons with the best (MCB) allows…

Methodology · Statistics 2020-08-07 William J. Artman , Ashkan Ertefaie , Kevin G. Lynch , James R. McKay

Artificial intelligence (AI) has significantly improved medical screening accuracy, particularly in cancer detection and risk assessment. However, traditional classification metrics often fail to account for imbalanced data, varying…

Machine Learning · Computer Science 2025-10-28 Longfei Wei , Fang Sheng , Jianfei Zhang

Context: The rise of Artificial Intelligence (AI) in software engineering has led to the development of AI-powered test automation tools, promising improved efficiency, reduced maintenance effort, and enhanced defect-detection. However, a…

Software Engineering · Computer Science 2025-05-02 Vahid Garousi , Nithin Joy , Zafar Jafarov , Alper Buğra Keleş , Sevde Değirmenci , Ece Özdemir , Ryan Zarringhalami

Multi-task learning is effective for related applications, but its performance can deteriorate when the target sample size is small. Transfer learning can borrow strength from related studies; yet, many existing methods rely on restrictive…

Machine Learning · Computer Science 2026-04-23 Boxin Zhao , Mladen Kolar , Jinchi Lv