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We study the dynamics of a model of membrane vesicle transport into dendritic spines, which are bulbous intracellular compartments in neurons driven by molecular motors. We reduce the lubrication model proposed in [Fai et al., Active…

Cell Behavior · Quantitative Biology 2020-11-19 Youngmin Park , Thomas G. Fai

We study the dynamics of molecular motor-driven transport into dendritic spines, which are bulbous intracellular compartments in neurons that play a key role in transmitting signals between neurons. We further develop a stochastic model of…

Subcellular Processes · Quantitative Biology 2025-10-27 Youngmin Park , Thomas G. Fai

A flexible membrane deforming its shape in time can self-propel in a viscous fluid. Alternatively, if the membrane is anchored, its deformation will lead to fluid transport. Past work in this area focused on situations where the deformation…

Soft Condensed Matter · Physics 2013-02-12 Arthur A. Evans , Eric Lauga

We study, numerically and analytically, the forced transport of deformable containers through a narrow constriction. Our central aim is to quantify the competition between the constriction geometry and the active forcing, regulating whether…

Soft Condensed Matter · Physics 2015-02-10 Remy Kusters , Thijs van der Heijden , Badr Kaoui , Jens Harting , Cornelis Storm

How internal forces are transduced into motion through soft, fluid membranes remains a fundamental question in the study of active systems. To investigate this coupling, we develop a minimal system consisting of a single ferromagnetic…

Soft Condensed Matter · Physics 2025-07-11 Paula Magrinya , Arin Escobar Ortiz , Juan L. Aragones , Laura R. Arriaga

Flexible filaments moving in viscous fluids are ubiquitous in the natural microscopic world. For example, the swimming of bacteria and spermatozoa as well as important physiological functions at organ-level, such as the cilia-induced motion…

Soft Condensed Matter · Physics 2019-06-05 Panayiota Katsamba , Eric Lauga

We study the dynamics of membrane vesicle motor transport into dendritic spines, which are bulbous intracellular compartments in neurons that play a key role in transmitting signals between neurons. We consider the stochastic analog of the…

Subcellular Processes · Quantitative Biology 2022-05-17 Youngmin Park , Prashant Singh , Thomas G. Fai

The transport of deformable objects including polymer particles, vesicles and cells, has been a subject of interest for several decades where the majority of experimental and theoretical studies have been focused on circular tubes. Due to…

Soft Condensed Matter · Physics 2017-11-28 Shamim M. Ahmmed , Naureen S. Suteria , Valeria Garbin , Siva A. Vanapalli

We consider numerical algorithms for the simulation of the rheology of two-dimensional vesicles suspended in a viscous Stokesian fluid. The vesicle evolution dynamics is governed by hydrodynamic and elastic forces. The elastic forces are…

Numerical Analysis · Mathematics 2015-06-17 Bryan Quaife , George Biros

While the collective motion of active particles has been studied extensively, effective strategies to navigate particle swarms without external guidance remain elusive. We introduce a method to control the trajectories of two-dimensional…

Soft Condensed Matter · Physics 2023-08-28 Sophie Y. Lee , Philipp W. A. Schönhöfer , Sharon C. Glotzer

We numerically investigate the hydrodynamics and membrane dynamics of multicomponent vesicles in two strongly confined geometries. This serves as a simplified model for red blood cells undergoing large deformations while traversing narrow…

Soft Condensed Matter · Physics 2023-08-21 Ashley Gannon , Bryan Quaife , Y. -N. Young

We use coarse-grained molecular dynamics simulations to study the motility of a 2D vesicle containing self-propelled rods, as a function of the vesicle bending rigidity and the number density, length, and activity of the enclosed rods.…

Soft Condensed Matter · Physics 2023-03-29 Sarvesh Uplap , Michael F. Hagan , Aparna Baskaran

Many biological examples of fluid-structure interaction, including the transit of red blood cells through the narrow slits in the spleen and the intracellular trafficking of vesicles into dendritic spines, involve the near-contact of…

Numerical Analysis · Mathematics 2017-12-20 Thomas G. Fai , Chris H. Rycroft

Elastic confinements play an important role in many soft matter systems and affect the transport properties of suspended particles in viscous flow. On the basis of low-Reynolds-number hydrodynamics, we present an analytical theory of the…

Fluid Dynamics · Physics 2019-04-12 Abdallah Daddi-Moussa-Ider , Badr Kaoui , Hartmut Löwen

The deformation and rupture of a lipid vesicle due to the forced normal approach of an inclusion are essential for optimizing the design of magnetic giant unilamellar vesicles [magGUVs, Malik et al., Nanoscale 17, 13720 (2025)], with…

Soft Condensed Matter · Physics 2025-12-16 Yuan-Nan Young , Bryan Quaife , Herve Nganguia , On Shun Pak , Jie Feng , Howard A. Stone

The interaction of surfaces in relative motion in wet environments is dominated by lubrication forces, which play a pivotal role in the dynamics of microscopic systems. Here, we develop motile vesicles that exploit lubrication forces to…

Recent experiments on active materials, such as dense bacterial suspensions and microtubule-kinesin motor mixtures, show a promising potential for achieving self-sustained flows. However, to develop active microfluidics it is necessary to…

Soft Condensed Matter · Physics 2019-01-23 Santhan Chandragiri , Amin Doostmohammadi , Julia M Yeomans , Sumesh P Thampi

Using both dynamical density functional theory and particle-resolved Brownian dynamics simulations, we explore the flow of two-dimensional colloidal solids and fluids driven through a linear channel with a geometric constriction. The flow…

Soft Condensed Matter · Physics 2016-05-25 Urs Zimmermann , Frank Smallenburg , Hartmut Löwen

We experimentally study the dynamics of active particles (APs) in a viscoelastic fluid under various geometrical constraints such as flat walls, spherical obstacles and cylindrical cavities. We observe that the main effect of the confined…

Soft Condensed Matter · Physics 2020-07-21 N Narinder , Juan Ruben Gomez-Solano , Clemens Bechinger

Soft lubrication has been shown to drastically affect the mobility of an object immersed in a viscous fluid in the vicinity of a purely elastic wall. In this theoretical study, we develop a minimal model incorporating viscoelasticity,…

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