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Many state of the art methods for the thermodynamic and kinetic characterization of large and complex biomolecular systems by simulation rely on ensemble approaches, where data from large numbers of relatively short trajectories are…

Data Analysis, Statistics and Probability · Physics 2017-04-05 Feliks Nüske , Hao Wu , Jan-Hendrik Prinz , Christoph Wehmeyer , Cecilia Clementi , Frank Noé

In this paper, we review the physical concepts of the nonequilibrium techniques for the calculation of free energies applied to magnetic systems using Monte Carlo simulations of different nonequilibrium processes. The methodology allows the…

Statistical Mechanics · Physics 2019-05-01 Samuel Cajahuaringa , Alex Antonelli

Markov state models (MSMs) have been broadly adopted for analyzing molecular dynamics trajectories, but the approximate nature of the models that results from coarse-graining into discrete states is a long-known limitation. We show…

Computational Physics · Physics 2021-05-31 John D. Russo , Jeremy Copperman , David Aristoff , Gideon Simpson , Daniel M. Zuckerman

Estimating the free energy in molecular simulation requires, implicitly or explicitly, counting how many times the system is observed in a finite region. If the simulation is biased by an external potential, the weight of the configurations…

Chemical Physics · Physics 2021-12-22 Matteo Carli , Alessandro Laio

Non-equilibrium Markov State Modeling (MSM) has recently been proposed [Phys. Rev. E 94, 053001 (2016)] as a possible route to construct a physical theory of sliding friction from a long steady state atomistic simulation: the approach…

Statistical Mechanics · Physics 2017-10-17 M. Teruzzi , F. Pellegrini , A. Laio , E. Tosatti

By quenching into the metastable region of the three-dimensional Ising model, we investigate the paths that the magnetization (energy) takes as a function of time. We accumulate the magnetization (energy) paths into time-dependent…

Statistical Mechanics · Physics 2015-06-24 Armando Ticona Bustillos , Dieter W. Heermann , Claudette E. Cordeiro

Markov state models (MSMs) have been demonstrated to be a powerful method for computationally studying intramolecular processes such as protein folding and macromolecular conformational changes. In this article, we present a new approach to…

Biological Physics · Physics 2015-06-18 Matthew R. Perkett , Michael F. Hagan

Computational modeling of assembly is challenging for many systems because their timescales vastly exceed those accessible to simulations. This article describes the MultiMSM, which is a general framework that uses Markov state models…

Soft Condensed Matter · Physics 2024-05-07 Anthony Trubiano , Michael F. Hagan

An oft-used concept in modeling macromolecules is the free energy landscape, obtained by coarse-graining a vast number of microstates into a low-dimensional mesh of mesostates. If the landscape contains two or more local minima…

Statistical Mechanics · Physics 2018-04-24 Daniel Sigg , Vincent A. Voelz , Vincenzo Carnevale

Generative models have advanced significantly in sampling material systems with continuous variables, such as atomistic structures. However, their application to discrete variables, like atom types or spin states, remains underexplored. In…

Statistical Mechanics · Physics 2025-11-18 Ping Tuo , Zezhu Zeng , Jiale Chen , Bingqing Cheng

This paper explores a discrete energy state transition model for energy harvesting (EH) in cell-free massive multiple-input multiple-output (CF-mMIMO) networks. Multiple-antenna access points (APs) provide wireless power and information to…

Signal Processing · Electrical Eng. & Systems 2024-09-04 Muhammad Zeeshan Mumtaz , Mohammadali Mohammadi , Hien Quoc Ngo , Michail Matthaiou

We explore the cooperative behaviour and phase transitions of interacting networks by studying a simplified model consisting of Ising spins placed on the nodes of two coupled Erd\"os-R\'enyi random graphs. We derive analytical expressions…

Statistical Mechanics · Physics 2018-08-27 Maíra Bolfe , Lucas Nicolao , Fernando L. Metz

Because of their multimodality, mixture posterior distributions are difficult to sample with standard Markov chain Monte Carlo (MCMC) methods. We propose a strategy to enhance the sampling of MCMC in this context, using a biasing procedure…

Computation · Statistics 2011-04-19 Nicolas Chopin , Tony Lelievre , Gabriel Stoltz

Markov State Models (MSM) are widely used to elucidate dynamic properties of molecular systems from unbiased Molecular Dynamics (MD). However, the implementation of reweighting schemes for MSMs to analyze biased simulations, for example…

Chemical Physics · Physics 2020-11-26 Stefanie Kieninger , Luca Donati , Bettina G. Keller

We study mean-field Ising models whose coupling depends on the magnetization via a feedback function. We identify mixed phases (MPs) and show that they can be stable at zero temperature for sufficiently strong feedback. Moreover, stable MPs…

Statistical Mechanics · Physics 2025-06-11 Yi-Ping Ma , Ivan Sudakow , P. L. Krapivsky

The evaluation of the free energy of a stochastic model is considered a significant issue in various fields of physics and machine learning. However, the exact free energy evaluation is computationally infeasible because the free energy…

Machine Learning · Statistics 2022-08-29 Muneki Yasuda , Chako Takahashi

We consider an Ising model with quenched surface disorder, the disorder average of the free energy is the main object of interest. Explicit expressions for the free energy distribution are difficult to obtain if the quenched surface spins…

Mathematical Physics · Physics 2024-10-30 Nils Gluth , Thomas Guhr , Alfred Hucht

Free energy as a function of polarization is calculated for the square-lattice $J_1$-$J_2$ Ising model for $J_2 < |J_1|/2$ using the random local field approximation (RLFA) and Monte Carlo (MC) simulations. Within RLFA, it reveals a…

Materials Science · Physics 2024-06-12 V. A. Abalmasov

The description of a three-dimensional Ising-like magnet in the presence of an external field in the vicinity of the critical point by the collective variables method is proposed. Using the renormalization group transformations, the scaling…

High Energy Physics - Theory · Physics 2009-11-11 M. P. Kozlovskii , I. V. Pylyuk , O. O. Prytula

We study a class of non-equilibrium quasi-stationary states for a Markov system interacting with two different thermal baths. We show that the work done under a slow, external change of parameters admits a potential, i.e., the free energy.…

Statistical Mechanics · Physics 2017-05-23 A. E. Allahverdyan , N. H. Martirosyan
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