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We focus on an alignment-free method to estimate the underlying signal from a large number of noisy randomly shifted observations. Specifically, we estimate the mean, power spectrum, and bispectrum of the signal from the observations. Since…

Signal Processing · Electrical Eng. & Systems 2018-07-04 Hua Chen , Mona Zehni , Zhizhen Zhao

Multireference alignment (MRA) refers to the problem of recovering a signal from noisy samples subject to random circular shifts. Expectation--maximization (EM) and variational approaches use statistical modeling to achieve high accuracy at…

Information Theory · Computer Science 2025-10-30 Vahid Shahverdi , Emanuel Ström , Joakim Andén

Multireference alignment (MRA) is the problem of estimating a signal from many noisy and cyclically shifted copies of itself. In this paper, we consider an extension called heterogeneous MRA, where $K$ signals must be estimated, and each…

Information Theory · Computer Science 2018-02-02 Nicolas Boumal , Tamir Bendory , Roy R. Lederman , Amit Singer

Multireference alignment (MRA) problem is to estimate an underlying signal from a large number of noisy circularly-shifted observations. The existing methods are always proposed under the hypothesis of a single Gaussian noise. However, the…

Optimization and Control · Mathematics 2021-07-23 Cuicui Zhao , Jun Liu , Xinqi Gong

Motivated by modern data applications such as cryo-electron microscopy, the goal of classic multi-reference alignment (MRA) is to recover an unknown signal $f: \mathbb{R} \to \mathbb{R}$ from many observations that have been randomly…

Signal Processing · Electrical Eng. & Systems 2024-02-23 Liping Yin , Anna Little , Matthew Hirn

This paper studies the multi-reference alignment (MRA) problem of estimating a signal function from shifted, noisy observations. Our functional formulation reveals a new connection between MRA and deconvolution: the signal can be estimated…

Information Theory · Computer Science 2026-05-19 Omar Al-Ghattas , Anna Little , Daniel Sanz-Alonso , Mikhail Sweeney

Motivated by structural biology applications, we study the projected multi-reference alignment (MRA) model, in which an unknown signal is observed through noisy samples, each generated by applying a random cyclic shift followed by a fixed…

Signal Processing · Electrical Eng. & Systems 2026-05-26 Amnon Balanov , Josh Katz , Tamir Bendory , Dan Edidin

The multi-reference alignment (MRA) problem involves reconstructing a signal from multiple noisy observations, each transformed by a random group element. In this paper, we focus on the group \(\mathrm{SO}(2)\) of in-plane rotations and…

Numerical Analysis · Mathematics 2025-05-07 Gil Drozatz , Tamir Bendory , Nir Sharon

Motivated by cutting-edge applications like cryo-electron microscopy (cryo-EM), the Multi-Reference Alignment (MRA) model entails the learning of an unknown signal from repeated measurements of its images under the latent action of a group…

Statistics Theory · Mathematics 2022-03-11 Subhro Ghosh , Philippe Rigollet

Motivated by the problem of determining the atomic structure of macromolecules using single-particle cryo-electron microscopy (cryo-EM), we study the sample and computational complexities of the sparse multi-reference alignment (MRA) model:…

Information Theory · Computer Science 2021-09-27 Tamir Bendory , Oscar Mickelin , Amit Singer

Rotation averaging (RA) is a fundamental problem in robotics and computer vision. In RA, the goal is to estimate a set of $N$ unknown orientations $R_{1}, ..., R_{N} \in SO(3)$, given noisy measurements $R_{ij} \sim R^{-1}_{i} R_{j}$ of a…

Computer Vision and Pattern Recognition · Computer Science 2023-11-29 Owen Howell , Haoen Huang , David Rosen

We study the problem of signal recovery in the dihedral multi-reference alignment (MRA) model, where a signal is observed under random actions of the dihedral group and corrupted by additive noise. While previous has shown that cyclic…

Commutative Algebra · Mathematics 2025-11-20 Dan Edidin , Josh Katz

We consider the problem of estimating the covariance matrix of a random signal observed through unknown translations (modeled by cyclic shifts) and corrupted by noise. Solving this problem allows to discover low-rank structures masked by…

Statistics Theory · Mathematics 2020-11-11 Boris Landa , Yoel Shkolnisky

We study the continuous multi-reference alignment model of estimating a periodic function on the circle from noisy and circularly-rotated observations. Motivated by analogous high-dimensional problems that arise in cryo-electron microscopy,…

Statistics Theory · Mathematics 2023-08-29 Zehao Dou , Zhou Fan , Harrison Zhou

Motivated by single-particle cryo-electron microscopy, multi-reference alignment (MRA) models the task of recovering an unknown signal from multiple noisy observations corrupted by random rotations. The standard approach,…

Signal Processing · Electrical Eng. & Systems 2026-01-09 Shay Kreymer , Amnon Balanov , Tamir Bendory

Phase-Rectified Signal Averaging (PRSA) was shown to be a powerful tool for the study of quasi-periodic oscillations and nonlinear effects in non-stationary signals. Here we present a bivariate PRSA technique for the study of the…

Data Analysis, Statistics and Probability · Physics 2009-11-13 Aicko Y. Schumann , Jan W. Kantelhardt , Axel Bauer , Georg Schmidt

The multi-reference alignment (MRA) problem entails estimating an image from multiple noisy and rotated copies of itself. If the noise level is low, one can reconstruct the image by estimating the missing rotations, aligning the images, and…

Signal Processing · Electrical Eng. & Systems 2022-06-17 Noam Janco , Tamir Bendory

We propose a Bayesian approach to the problem of multi-reference alignment -- the recovery of signals from noisy, randomly shifted observations. While existing frequentist methods accurately recover the signal at arbitrarily low…

Signal Processing · Electrical Eng. & Systems 2025-10-15 Axel Janson , Joakim Andén

This article discusses a generalization of the 1-dimensional multi-reference alignment problem. The goal is to recover a hidden signal from many noisy observations, where each noisy observation includes a random translation and random…

Signal Processing · Electrical Eng. & Systems 2021-07-06 Matthew Hirn , Anna Little

Multi-segment reconstruction (MSR) problem consists of recovering a signal from noisy segments with unknown positions of the observation windows. One example arises in DNA sequence assembly, which is typically solved by matching short reads…

Signal Processing · Electrical Eng. & Systems 2018-02-27 Mona Zehni , Minh N. Do , Zhizhen Zhao
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