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Molecular dynamics (MD) simulations are widely used to study large-scale molecular systems. HPC systems are ideal platforms to run these studies, however, reaching the necessary simulation timescale to detect rare processes is challenging,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-08-22 Tu Mai Anh Do , Loïc Pottier , Rafael Ferreira da Silva , Frédéric Suter , Silvina Caíno-Lores , Michela Taufer , Ewa Deelman

Metadynamics (MTD) is a very powerful technique to sample high-dimensional free energy landscapes, and due to its self-guiding property, the method has been successful in studying complex reactions and conformational changes. MTD sampling…

Computational Physics · Physics 2016-02-05 Shalini Awasthi , Venkat Kapil , Nisanth N. Nair

In the last few decades, several novel algorithms have been designed for finding critical points on PES and the minimum energy paths connecting them. This has led to considerably improve our understanding of reaction mechanisms and kinetics…

Computational Engineering, Finance, and Science · Computer Science 2024-10-30 Sandra Liz Simon , Nitin Kaistha , Vishal Agarwal

Simulation systems have become an essential component in the development and validation of autonomous driving technologies. The prevailing state-of-the-art approach for simulation is to use game engines or high-fidelity computer graphics…

Computer Vision and Pattern Recognition · Computer Science 2020-10-30 Wei Li , Chengwei Pan , Rong Zhang , Jiaping Ren , Yuexin Ma , Jin Fang , Feilong Yan , Qichuan Geng , Xinyu Huang , Huajun Gong , Weiwei Xu , Guoping Wang , Dinesh Manocha , Ruigang Yang

Molecular dynamics (MD) simulations are powerful tools for elucidating the macroscopic physical properties of materials from microscopic atomic behaviors. However, the massive, high-dimensional datasets generated by MD simulations pose a…

Applications · Statistics 2026-03-19 Yusuke Ono , Takumi Sato , Kenji Yasuoka , Linyu Peng

Compressed sensing (CS) is a new signal acquisition paradigm that enables the reconstruction of signals and images from a low number of samples. A particularly exciting application of CS is Magnetic Resonance Imaging (MRI), where CS…

Information Theory · Computer Science 2016-08-17 Samuel Birns , Bohyun Kim , Stephanie Ku , Kevin Stangl , Deanna Needell

We propose a novel method for sampling and optimization tasks based on a stochastic interacting particle system. We explain how this method can be used for the following two goals: (i) generating approximate samples from a given target…

Dynamical Systems · Mathematics 2021-11-05 J. A. Carrillo , F. Hoffmann , A. M. Stuart , U. Vaes

Model Predictive Control (MPC) has established itself as the primary methodology for constrained control, enabling autonomy across diverse applications. While model fidelity is crucial in MPC, solving the corresponding optimization problem…

Systems and Control · Electrical Eng. & Systems 2026-04-23 Lukas Schroth , Daniel Morton , Amon Lahr , Daniele Gammelli , Andrea Carron , Marco Pavone

Modern problems in astronomical Bayesian inference require efficient methods for sampling from complex, high-dimensional, often multi-modal probability distributions. Most popular methods, such as Markov chain Monte Carlo sampling, perform…

Instrumentation and Methods for Astrophysics · Physics 2016-03-16 Will Vousden , Will M. Farr , Ilya Mandel

Recent deep network-based compressive sensing (CS) methods have achieved great success. However, most of them regard different sampling matrices as different independent tasks and need to train a specific model for each target sampling…

Computer Vision and Pattern Recognition · Computer Science 2021-07-16 Di You , Jian Zhang , Jingfen Xie , Bin Chen , Siwei Ma

Multi-modal learning aims to enhance performance by unifying models from various modalities but often faces the "modality imbalance" problem in real data, leading to a bias towards dominant modalities and neglecting others, thereby limiting…

Computer Vision and Pattern Recognition · Computer Science 2024-04-15 Yang Yang , Hongpeng Pan , Qing-Yuan Jiang , Yi Xu , Jinghui Tang

The goal of this paper is to design image classification systems that, after an initial multi-task training phase, can automatically adapt to new tasks encountered at test time. We introduce a conditional neural process based approach to…

Machine Learning · Statistics 2020-07-14 James Requeima , Jonathan Gordon , John Bronskill , Sebastian Nowozin , Richard E. Turner

Cellular Automata (CAs) are computational models that can capture the essential features of systems in which global behavior emerges from the collective effect of simple components, which interact locally. During the last decades, CAs have…

A self-learning adaptive system (SLAS) uses machine learning to enable and enhance its adaptability. Such systems are expected to perform well in dynamic situations. For learning high-performance adaptation policy, some assumptions must be…

Software Engineering · Computer Science 2021-05-12 Mingyue Zhang , Jialong Li , Haiyan Zhao , Kenji Tei , Shinichi Honiden , Zhi Jin

Constraint-based modeling has been widely used on metabolic networks analysis, such as biosynthetic prediction and flux optimization. The linear constraints, like mass conservation constraint, reversibility constraint, biological capacity…

Other Quantitative Biology · Quantitative Biology 2009-11-29 Lu Xie , Yi Zhang

Understanding the dynamic behavior of biomolecules is fundamental to elucidating biological function and facilitating drug discovery. While Molecular Dynamics (MD) simulations provide a rigorous physical basis for studying these dynamics,…

Biomolecules · Quantitative Biology 2026-03-19 Liang Shi , Jiarui Lu , Junqi Liu , Chence Shi , Zhi Yang , Jian Tang

When simulating multiscale stochastic differential equations (SDEs) in high-dimensions, separation of timescales, stochastic noise and high-dimensionality can make simulations prohibitively expensive. The computational cost is dictated by…

Dynamical Systems · Mathematics 2015-10-13 Miles Crosskey , Mauro Maggioni

Engineering collective adaptive systems (CAS) with learning capabilities is a challenging task due to their multi-dimensional and complex design space. Data-driven approaches for CAS design could introduce new insights enabling system…

Software Engineering · Computer Science 2020-08-11 Mirko D'Angelo , Sona Ghahremani , Simos Gerasimou , Johannes Grohmann , Ingrid Nunes , Sven Tomforde , Evangelos Pournaras

Recent advancements in Artificial Neural Networks have significantly improved human activity recognition using multiple time-series sensors. While employing numerous sensors with high-frequency sampling rates usually improves the results,…

Signal Processing · Electrical Eng. & Systems 2024-10-11 Mengxi Liu , Zimin Zhao , Daniel Geißler , Bo Zhou , Sungho Suh , Paul Lukowicz

The adoption of detailed mechanisms for chemical kinetics often poses two types of severe challenges: First, the number of degrees of freedom is large; and second, the dynamics is characterized by widely disparate time scales. As a result,…

Dynamical Systems · Mathematics 2025-10-01 Eliodoro Chiavazzo , C. William Gear , Carmeline J. Dsilva , Neta Rabin , Ioannis G. Kevrekidis