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Phase separation and transitions among different molecular states are ubiquitous in living cells. Such transitions can be governed by local equilibrium thermodynamics or by active processes controlled by biological fuel. It remains largely…

Biological Physics · Physics 2021-11-24 G. Bartolucci , O. Adame-Arana , X. Zhao , C. A. Weber

Phase separation under non-equilibrium conditions is exploited by biological cells to organize their cytoplasm but remains poorly understood as a physical phenomenon. Here, we study a ternary fluid model in which phase-separating molecules…

Soft Condensed Matter · Physics 2018-02-21 Jean David Wurtz , Chiu Fan Lee

The microscopic model in which nodes interacting with each other are statistical systems is introduced. The nodes conditions are connected with a string of distinct microscopic configurations and depend on external parameters (pressure and…

Statistical Mechanics · Physics 2007-05-23 V. Stepanov

Discontinuous phase transitions occurs to be particularly interesting from a social point of view because of their relationship to social hysteresis and critical mass. In this paper, we show that the replacement of a time-varying (annealed,…

Physics and Society · Physics 2022-08-31 Bartłomiej Nowak , Katarzyna Sznajd-Weron

Living cells use phase separation and concentration gradients to organize chemical compartments in space. Here, we present a theoretical study of droplet dynamics in gradient systems. We derive the corresponding growth law of droplets and…

Biological Physics · Physics 2017-05-19 Christoph A. Weber , Chiu Fan Lee , Frank Jülicher

Motivated by intracellular phase separation, we theoretically investigate how molecular orientation and multi-component nature affect phase behavior. We construct a minimal model for a ternary mixture composed of isotropic (I), anisotropic…

Soft Condensed Matter · Physics 2026-03-12 Hiroshi Yokota

Phase-separated liquid condensates can spatially organize and thereby regulate chemical processes. However, the physicochemical mechanisms underlying such regulation remain elusive as the intramolecular interactions responsible for phase…

Soft Condensed Matter · Physics 2024-03-11 Sudarshana Laha , Jonathan Bauermann , Frank Jülicher , Thomas C. T. Michaels , Christoph A. Weber

When studying out-of-equilibrium systems, one often excites the dynamics in some degrees of freedom while removing the excitation in others through damping. In order for the system to converge to a statistical steady state, the dynamics…

Probability · Mathematics 2025-03-26 David P. Herzog , Jonathan C. Mattingly

We investigate both continuous (second-order) and discontinuous (first-order) transitions to macroscopic synchronization within a single class of discrete, stochastic (globally) phase-coupled oscillators. We provide analytical and numerical…

Statistical Mechanics · Physics 2009-11-13 Kevin Wood , C. Van den Broeck , R. Kawai , Katja Lindenberg

Mechanical interactions between biological cells may be mediated by secreted products, making them dependent on the local particle density. Here, we explore the generic physics of density-dependent attractive interactions. We show using…

Soft Condensed Matter · Physics 2017-11-29 Gavin Melaugh , Davide Marenduzzo , Alexander Morozov , Rosalind J. Allen

Biological mixtures such as the cytosol may consist of thousands of distinct components. There is now a substantial body of evidence showing that, under physiological conditions, intracellular mixtures can phase separate into spatially…

Soft Condensed Matter · Physics 2017-03-06 William M. Jacobs , Daan Frenkel

Recent studies have shown that one-dimensional driven systems can exhibit phase separation even if the dynamics is governed by local rules. The ABC model, which comprises three particle species that diffuse asymmetrically around a ring,…

Statistical Mechanics · Physics 2016-08-31 M. Clincy , B. Derrida , M. R. Evans

In this work we identify and investigate a novel bifurcation in conserved systems. This secondary bifurcation stops active phase separation in its nonlinear regime. It is then either replaced by an extended, system-filling, spatially…

Pattern Formation and Solitons · Physics 2022-02-22 Frederik J. Thomsen , Lisa Rapp , Fabian Bergmann , Walter Zimmermann

A class of models of driven diffusive systems which is shown to exhibit phase separation in $d=1$ dimensions is introduced. Unlike all previously studied models exhibiting similar phenomena, here the phase separated state is fluctuating in…

Statistical Mechanics · Physics 2009-11-07 Y. Kafri , E. Levine , D. Mukamel , G. M. Schutz , R. D. Willmann

We consider a model in which positive and negative particles with equal densities diffuse in an asymmetric, CP invariant way on a ring. The positive particles hop clockwise, the negative counter-clockwise and oppositely-charged adjacent…

Statistical Mechanics · Physics 2015-06-25 Peter F. Arndt , Thomas Heinzel , Vladimir Rittenberg

A new simple method for the first order phase transition kinetics is suggested. The metastable phase consumption can be imagined in frames of the modisperse approximation for the distribution of the droplets sizes. In all situations of the…

Atmospheric and Oceanic Physics · Physics 2007-05-23 V. Kurasov

We investigate the stationary states of one-dimensional driven diffusive systems, coupled to boundary reservoirs with fixed particle densities. We argue that the generic phase diagram is governed by an extremal principle for the macroscopic…

Statistical Mechanics · Physics 2009-10-31 Vladislav Popkov , Gunter M. Schuetz

Conventional phase segregation is controlled by a positive interfacial tension, which implies that the system relaxes towards a state in which the interfacial area (or length) is minimized, typically manifesting as a single droplet that…

Soft Condensed Matter · Physics 2025-09-24 Kathrin Hertäg , Joshua F. Robinson , Thomas Speck

Biological cells exhibit a hierarchical spatial organization, where various compartments harbor condensates that form by phase separation. Cells can control the emergence of these condensates by affecting compartment size, the amount of the…

Biological Physics · Physics 2025-04-03 Riccardo Rossetto , Gerrit Wellecke , David Zwicker

We review recent theoretical advances on controlling the fluid-fluid phase transition with electric fields. Using a mean-field approach, we compare the effects of uniform versus non-uniform electric fields, and show how non-uniform fields…

Soft Condensed Matter · Physics 2012-12-07 Jennifer Galanis , Sela Samin , Yoav Tsori
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