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We establish necessary and sufficient conditions for consistent root reconstruction in continuous-time Markov models with countable state space on bounded-height trees. Here a root state estimator is said to be consistent if the probability…

Probability · Mathematics 2019-08-02 Wai-Tong Louis Fan , Sebastien Roch

We present a randomized algorithm for reconstructing directed rooted trees of $n$ nodes and node degree at most $d$, by asking at most $O(dn\log^2 n)$ path queries. Each path query takes as input an origin node and a target node, and…

Data Structures and Algorithms · Computer Science 2017-11-20 Zhaosen Wang , Jean Honorio

Maximum likelihood is one of the most widely used techniques to infer evolutionary histories. Although it is thought to be intractable, a proof of its hardness has been lacking. Here, we give a short proof that computing the maximum…

Probability · Mathematics 2011-09-30 S. Roch

Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descendant sequences at the tip of the tree. In addition to its many…

Populations and Evolution · Quantitative Biology 2022-07-27 Brandon Legried , Sebastien Roch

We give a greedy learning algorithm for reconstructing an evolutionary tree based on a certain harmonic average on triplets of terminal taxa. After the pairwise distances between terminal taxa are estimated from sequence data, the algorithm…

Data Structures and Algorithms · Computer Science 2007-05-23 Miklos Csuros , Ming-Yang Kao

Random forests construct each tree with a different, randomised representation of the feature space. Their uniform voting cannot correct errors in regions where trees with incorrect representations probabilistically outnumber correct ones,…

Machine Learning · Computer Science 2026-05-28 Youngjoon Park

In phylogenetics, a central problem is to infer the evolutionary relationships between a set of species $X$; these relationships are often depicted via a phylogenetic tree -- a tree having its leaves univocally labeled by elements of $X$…

Data Structures and Algorithms · Computer Science 2016-04-12 Julien Baste , Christophe Paul , Ignasi Sau , Celine Scornavacca

Quartet Reconstruction, the task of recovering a phylogenetic tree from smaller trees on four species called \textit{quartets}, is a well-studied problem in theoretical computer science with far-reaching connections to statistics, graph…

Data Structures and Algorithms · Computer Science 2026-04-21 Dionysis Arvanitakis , Vaggos Chatziafratis , Yiyuan Luo , Konstantin Makarychev

It is common in phylogenetics to have some, perhaps partial, information about the overall evolutionary tree of a group of organisms and wish to find an evolutionary tree of a specific gene for those organisms. There may not be enough…

Populations and Evolution · Quantitative Biology 2018-01-09 Vu Dinh , Lam Si Tung Ho , Marc A. Suchard , Frederick A. Matsen

Rooted phylogenetic networks provide an explicit representation of the evolutionary history of a set $X$ of sampled species. In contrast to phylogenetic trees which show only speciation events, networks can also accommodate reticulate…

Combinatorics · Mathematics 2021-01-01 Peter L. Erdos , Charles Semple , Mike Steel

Evolutionary events such as incomplete lineage sorting and lateral gene transfer constitute major problems for inferring species trees from gene trees, as they can sometimes lead to gene trees which conflict with the underlying species…

Populations and Evolution · Quantitative Biology 2013-04-23 Andreas Sand , Mike Steel

A variety of algorithms have been proposed for reconstructing trees that show the evolutionary relationships between species by comparing differences in genetic data across present-day taxa. If the leaf-to-leaf distances in a tree can be…

Populations and Evolution · Quantitative Biology 2014-11-18 Olivier Gascuel , Mike Steel

We introduce a new phylogenetic reconstruction algorithm which, unlike most previous rigorous inference techniques, does not rely on assumptions regarding the branch lengths or the depth of the tree. The algorithm returns a forest which is…

Populations and Evolution · Quantitative Biology 2011-09-30 Constantinos Daskalakis , Elchanan Mossel , Sebastien Roch

In evolutionary biology, genetic sequences carry with them a trace of the underlying tree that describes their evolution from a common ancestral sequence. The question of how many sequence sites are required to recover this evolutionary…

Populations and Evolution · Quantitative Biology 2008-06-17 Mareike Fischer , Mike Steel

We present the first sub-quadratic time algorithm that with high probability correctly reconstructs phylogenetic trees for short sequences generated by a Markov model of evolution. Due to rapid expansion in sequence databases, such very…

Populations and Evolution · Quantitative Biology 2012-06-01 Daniel G. Brown , Jakub Truszkowski

Reconciling a gene tree with a species tree is an important task that reveals much about the evolution of genes, genomes, and species, as well as about the molecular function of genes. A wide array of computational tools have been devised…

Populations and Evolution · Quantitative Biology 2012-12-11 Yun Yu , Luay Nakhleh

Most genes are part of larger families of evolutionary related genes. The history of gene families typically involves duplications and losses of genes as well as horizontal transfers into other organisms. The reconstruction of detailed gene…

Populations and Evolution · Quantitative Biology 2023-04-25 Marc Hellmuth , Peter F. Stadler

An evolutionary tree is a cascade of bifurcations starting from a single common root, generating a growing set of daughter species as time goes by. Species here is a general denomination for biological species, spoken languages or any other…

Quantitative Methods · Quantitative Biology 2013-08-26 Paulo Murilo Castro de Oliveira

Ancestral maximum likelihood (AML) is a method that simultaneously reconstructs a phylogenetic tree and ancestral sequences from extant data (sequences at the leaves). The tree and ancestral sequences maximize the probability of observing…

Populations and Evolution · Quantitative Biology 2017-07-24 Elchanan Mossel , Sebastien Roch , Mike Steel

Many fundamental statistical methods have become critical tools for scientific data analysis yet do not scale tractably to modern large datasets. This paper will describe very recent algorithms based on computational geometry which have…

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