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We propose a regression model for non-central $\chi$ (NC-$\chi$) distributed functional magnetic resonance imaging (fMRI) and diffusion weighted imaging (DWI) data, with the heteroscedastic Rician regression model as a prominent special…
The Diffusion Probabilistic Model (DPM) has demonstrated remarkable performance across a variety of generative tasks. The inherent randomness in diffusion models helps address issues such as blurring at the edges of medical images and…
Accurate segmentation of brain tissue in magnetic resonance images (MRI) is a diffcult task due to different types of brain abnormalities. Using information and features from multimodal MRI including T1, T1-weighted inversion recovery…
Anomaly localization in images -- identifying regions that deviate from normal patterns -- is vital in applications such as medical diagnosis and industrial inspection. A recent trend is the use of image generation models in anomaly…
Magnetic resonance diffusion tensor imaging (DTI) is a critical tool for neural disease diagnosis. However, long scan time greatly hinders the widespread clinical use of DTI. To accelerate image acquisition, a feature-enhanced joint…
Despite the digital nature of magnetic resonance imaging, the resulting observations are most frequently reported and stored in text documents. There is a trove of information untapped in medical health records, case reports, and medical…
We consider the estimation and inference of graphical models that characterize the dependency structure of high-dimensional tensor-valued data. To facilitate the estimation of the precision matrix corresponding to each way of the tensor, we…
Brain midline shift (MLS) is one of the most critical factors to be considered for clinical diagnosis and treatment decision-making for intracranial hemorrhage. Existing computational methods on MLS quantification not only require intensive…
The assessment of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) associated with brain changes remains a challenging task. Recent studies have demonstrated that combination of multi-modality imaging techniques can better…
Unsupervised anomaly detection in brain images is crucial for identifying injuries and pathologies without access to labels. However, the accurate localization of anomalies in medical images remains challenging due to the inherent…
We estimate the distribution of random parameters in a distributed parameter model with unbounded input and output for the transdermal transport of ethanol in humans. The model takes the form of a diffusion equation with the input being the…
Diffusion tensor imaging (DTI) provides crucial insights into the microstructure of the human brain, but it can be time-consuming to acquire compared to more readily available T1-weighted (T1w) magnetic resonance imaging (MRI). To address…
Magnetic Resonance Imaging (MRI) is a principal diagnostic approach used in the field of radiology to create images of the anatomical and physiological structure of patients. MRI is the prevalent medical imaging practice to find…
Multi-center neuroimaging studies face technical variability due to batch differences across sites, which potentially hinders data aggregation and impacts study reliability.Recent efforts in neuroimaging harmonization have aimed to minimize…
The prediction and selection of lesion features are two important tasks in voxel-based neuroimage analysis. Existing multivariate learning models take two tasks equivalently and optimize simultaneously. However, in addition to lesion…
CT perfusion (CTP) has been used to triage ischemic stroke patients in the early stage, because of its speed, availability, and lack of contraindications. Perfusion parameters including cerebral blood volume (CBV), cerebral blood flow…
In voxel-based neuroimage analysis, lesion features have been the main focus in disease prediction due to their interpretability with respect to the related diseases. However, we observe that there exists another type of features introduced…
Purpose: To compare the segmentation and detection performance of a deep learning model trained on a database of human-labelled clinical diffusion-weighted (DW) stroke lesions to a model trained on the same database enhanced with synthetic…
3D brain MRI studies often examine subtle morphometric differences between cohorts that are hard to detect visually. Given the high cost of MRI acquisition, these studies could greatly benefit from image syntheses, particularly…
Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is widely used to evaluate acute ischemic stroke to distinguish salvageable tissue and infarct core. For this purpose, traditional methods employ deconvolution techniques,…