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A novel phase-space source implementation has been designed for GPU-based Monte Carlo dose calculation engines. Due to the parallelized nature of GPU hardware, it is essential to simultaneously transport particles of the same type and…

Medical Physics · Physics 2013-06-21 Reid Townson , Xun Jia , Zhen Tian , Yan Jiang Graves , Sergei Zavgorodni , Steve B Jiang

An MRI-only adaptive radiotherapy (ART) workflow is desirable for managing interfractional changes in anatomy, but producing synthetic CT (sCT) data through paired data-driven deep learning (DL) for abdominal dose calculations remains a…

In this paper we present a fast method based on successive convexification for generating fuel-optimized spacecraft rendezvous trajectories in the presence of mixed-integer constraints. A recently developed paradigm of state-triggered…

Optimization and Control · Mathematics 2019-06-13 Danylo Malyuta , Taylor P. Reynolds , Michael Szmuk , Behcet Acikmese , Mehran Mesbahi

Background: Ultra-high dose rate proton therapy shows promise in tissue sparing by enhancing therapeutic ratio through the FLASH effect. In radiotherapy, accurate in vivo dosimetry is crucial for quality assurance, but remains challenging…

Objective: Proton spot-scanning arc therapy (ARC) is an emerging modality that can improve the high-dose conformity to targets compared with standard intensity-modulated proton therapy (IMPT). However, the efficient treatment delivery of…

We present a batch trajectory optimizer that can simultaneously solve hundreds of different instances of the problem in real-time. We consider holonomic robots but relax the assumption of circular base footprint. Our main algorithmic…

Robotics · Computer Science 2021-09-28 Fatemeh Rastgar , Houman Masnavi , Karl Kruusamäe , Alvo Aabloo , Arun Kumar Singh

Ultra low radiation dose in X-ray Computed Tomography (CT) is an important clinical objective in order to minimize the risk of carcinogenesis. Compressed Sensing (CS) enables significant reductions in radiation dose to be achieved by…

Purpose: Prior AI-based dose prediction studies in photon and proton therapy often neglect underlying physics, limiting their generalizability to handle outlier clinical cases, especially for pencil beam scanning proton therapy (PBSPT). Our…

Dosimetry of salivary glands (SGs) is usually implemented using simplified calculation approaches and approximated geometries. Our aims were to compare different dosimetry methods to calculate SGs absorbed doses (ADs) following…

Postpartum hemorrhage (PPH) remains a leading cause of maternal morbidity and mortality worldwide. Oxytocin, though widely recognized for facilitating labor, is also the primary pharmacological intervention for PPH prevention. However,…

Methodology · Statistics 2026-04-02 Haiyan Zhu , Yuqi Qiu , Yingchun Zhou

Optimization of Reconfigurable Intelligent Surfaces (RIS) via a previously introduced method is effective, but time-consuming, because multiport impedance or scatter matrices are required for each transmitter and receiver position, which…

Optimization and Control · Mathematics 2025-01-31 Hans-Dieter Lang , Michel A. Nyffenegger , Heinz Mathis , Xingqi Zhang

The primal-dual hybrid gradient (PDHG) algorithm for solving convex optimization problems that arise in tomographic imaging is revisited. In particular, simplification of the selection of step-size parameters is developed for optimization…

Optimization and Control · Mathematics 2026-04-28 Emil Y. Sidky , John Paul Phillips , Zheng Zhang , Dan Xia , Ingrid S. Reiser , Xiaochuan Pan

Online adaptive radiation therapy (ART) has great promise to significantly reduce normal tissue toxicity and/or improve tumor control through real-time treatment adaptations based on the current patient anatomy. However, the major technical…

Medical Physics · Physics 2015-05-18 Chunhua Men , Xun Jia , Steve. B. Jiang

Many applications using large datasets require efficient methods for minimizing a proximable convex function subject to satisfying a set of linear constraints within a specified tolerance. For this task, we present a proximal projection…

Optimization and Control · Mathematics 2024-12-10 Howard Heaton

In this paper, we study the efficiency of a {\bf R}estarted {\bf S}ub{\bf G}radient (RSG) method that periodically restarts the standard subgradient method (SG). We show that, when applied to a broad class of convex optimization problems,…

Optimization and Control · Mathematics 2018-11-13 Tianbao Yang , Qihang Lin

Two new optimization techniques based on projections onto convex space (POCS) framework for solving convex and some non-convex optimization problems are presented. The dimension of the minimization problem is lifted by one and sets…

Optimization and Control · Mathematics 2013-06-14 A. Enis Cetin , Alican Bozkurt , Osman Gunay , Y. Hakan Habiboglu , Kivanc Kose , Ibrahim Onaran , R. A. Sevimli

Radiation therapy is the primary method used to treat cancer in the clinic. Its goal is to deliver a precise dose to the planning target volume (PTV) while protecting the surrounding organs at risk (OARs). However, the traditional workflow…

Image and Video Processing · Electrical Eng. & Systems 2024-04-10 Tara Gheshlaghi , Shahabedin Nabavi , Samire Shirzadikia , Mohsen Ebrahimi Moghaddam , Nima Rostampour

Monte Carlo (MC) simulation is considered the gold standard method for radiotherapy dose calculation. However, achieving high precision requires a large number of simulation histories, which is time consuming. The use of computer graphics…

Computer Vision and Pattern Recognition · Computer Science 2020-12-24 Ti Bai , Biling Wang , Dan Nguyen , Steve Jiang

Treatment planning system calculations in inhomogeneous regions may present significant inaccuracies due to loss of electronic equilibrium. In this study, three different dose calculation algorithms, pencil beam, collapsed cone, and…

Medical Physics · Physics 2015-03-12 Sung Jin Kim , Dong Ho Kim , Sung Kyu Kim

Traditionally, optimization of radiation therapy (RT) treatment plans has been done before the initiation of RT course, using population-wide estimates for patients' response to therapy. However, recent technological advancements have…

Medical Physics · Physics 2021-02-15 Stefan C. M. ten Eikelder , Ali Ajdari , Thomas Bortfeld , Dick den Hertog