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The emergence and development of cancer is a consequence of the accumulation over time of genomic mutations involving a specific set of genes, which provides the cancer clones with a functional selective advantage. In this work, we model…

Machine Learning · Computer Science 2017-03-10 Daniele Ramazzotti , Marco S. Nobile , Paolo Cazzaniga , Giancarlo Mauri , Marco Antoniotti

Generalized-ensemble Monte Carlo simulations such as the multicanonical method and similar techniques are among the most efficient approaches for simulations of systems undergoing discontinuous phase transitions or with rugged free- energy…

Computational Physics · Physics 2018-02-06 Jonathan Gross , Johannes Zierenberg , Martin Weigel , Wolfhard Janke

The joint modeling of longitudinal and time-to-event outcomes has become a popular tool in follow-up studies. However, fitting Bayesian joint models to large datasets, such as patient registries, can require extended computing times. To…

The main goal in many fields in the empirical sciences is to discover causal relationships among a set of variables from observational data. PC algorithm is one of the promising solutions to learn underlying causal structure by performing a…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-01-22 Behrooz Zarebavani , Foad Jafarinejad , Matin Hashemi , Saber Salehkaleybar

Bayesian spectral deconvolution provides a data-driven framework for mathematical model selection and parameter estimation from spectral data. Although highly versatile, it becomes computationally expensive as the number of model…

Computation · Statistics 2026-04-07 Tomohiro Nabika , Yui Hayashi , Masato Okada

Binary code analysis is widely used to assess a program's correctness, performance, and provenance. Binary analysis applications often construct control flow graphs, analyze data flow, and use debugging information to understand how machine…

Computation of a signal's estimated covariance matrix is an important building block in signal processing, e.g., for spectral estimation. Each matrix element is a sum of products of elements in the input matrix taken over a sliding window.…

Data Structures and Algorithms · Computer Science 2013-03-12 Oded Green , Lior David , Ami Galperin , Yitzhak Birk

Butterflies are the smallest non-trivial subgraph in bipartite graphs, and therefore having efficient computations for analyzing them is crucial to improving the quality of certain applications on bipartite graphs. In this paper, we design…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-06-18 Jessica Shi , Julian Shun

Multiple kernel learning algorithms are proposed to combine kernels in order to obtain a better similarity measure or to integrate feature representations coming from different data sources. Most of the previous research on such methods is…

Machine Learning · Computer Science 2012-07-03 Mehmet Gonen

Bayesian methods for learning Gaussian graphical models offer a principled framework for quantifying model uncertainty and incorporating prior knowledge. However, their scalability is constrained by the computational cost of jointly…

Methodology · Statistics 2025-08-28 Reza Mohammadi , Marit Schoonhoven , Lucas Vogels , S. Ilker Birbil

Embarrassingly parallel Markov Chain Monte Carlo (MCMC) exploits parallel computing to scale Bayesian inference to large datasets by using a two-step approach. First, MCMC is run in parallel on (sub)posteriors defined on data partitions.…

Machine Learning · Statistics 2022-03-31 Daniel Augusto de Souza , Diego Mesquita , Samuel Kaski , Luigi Acerbi

Time series analysis has emerged as an important tool for improving patient diagnosis and management in healthcare applications. However, these applications commonly face two critical challenges: time misalignment and data sparsity.…

Machine Learning · Statistics 2025-09-25 Dohyun Ku , Catherine D. Chong , Visar Berisha , Todd J. Schwedt , Jing Li

Heterogeneity in the cell population of cancer tissues poses many challenges in cancer diagnosis and treatment. Studying the heterogeneity in cell populations from gene expression measurement data in the context of cancer research is a…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-01-31 Anik Chaudhuri , Anwoy Mohanty , Manoranjan Satpathy

Mixture models provide a flexible representation of heterogeneity in a finite number of latent classes. From the Bayesian point of view, Markov Chain Monte Carlo methods provide a way to draw inferences from these models. In particular,…

Methodology · Statistics 2020-05-06 Carolina Valani Cavalcante , Kelly Cristina Mota Gonçalves

We use a graphics processing unit (GPU) for fast computations of Monte Carlo integrations. Two widely used Monte Carlo integration programs, VEGAS and BASES, are parallelized on GPU. By using $W^{+}$ plus multi-gluon production processes at…

Computational Physics · Physics 2011-03-03 J. Kanzaki

This paper introduces a framework for speeding up Bayesian inference conducted in presence of large datasets. We design a Markov chain whose transition kernel uses an (unknown) fraction of (fixed size) of the available data that is randomly…

Methodology · Statistics 2018-06-01 Florian Maire , Nial Friel , Pierre Alquier

Statistical analysis of microbiome data is challenging. Bayesian multinomial logistic-normal (MLN) models have gained popularity due to their ability to account for the count compositional nature of these data, but existing approaches are…

Methodology · Statistics 2025-05-27 Tinghua Chen , Michelle Pistner Nixon , Justin D. Silverman

This study introduces a computationally efficient algorithm, delayed acceptance Markov chain Monte Carlo (DA-MCMC), designed to improve posterior simulation in quasi-Bayesian inference. Quasi-Bayesian methods, which do not require fully…

Computation · Statistics 2026-02-16 Masahiro Tanaka

Score-based algorithms that learn the structure of Bayesian networks can be used for both exact and approximate solutions. While approximate learning scales better with the number of variables, it can be computationally expensive in the…

Machine Learning · Computer Science 2022-02-22 Zhigao Guo , Anthony C. Constantinou

This work introduces a new method designed for Bayesian deep learning called scalable Bayesian Monte Carlo (SBMC). The method is comprised of a model and an algorithm. The model interpolates between a point estimator and the posterior. The…