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Single-cell RNA sequencing (scRNA-seq) enables the study of cellular heterogeneity. Yet, clustering accuracy, and with it downstream analyses based on cell labels, remain challenging due to measurement noise and biological variability. In…

Machine Learning · Computer Science 2026-03-03 Dominik Meier , Shixing Yu , Sagnik Nandy , Promit Ghosal , Kyra Gan

Multiple clustering has gathered significant attention in recent years due to its potential to reveal multiple hidden structures of the data from different perspectives. Most of multiple clustering methods first derive feature…

Computer Vision and Pattern Recognition · Computer Science 2024-02-09 Jiawei Yao , Juhua Hu

Selecting subsets of features that differentiate between two conditions is a key task in a broad range of scientific domains. In many applications, the features of interest form clusters with similar effects on the data at hand. To recover…

Machine Learning · Computer Science 2022-11-11 Ram Dyuthi Sristi , Gal Mishne , Ariel Jaffe

Improved understanding of charge-transport in single molecules is essential for harnessing the potential of molecules e.g. as circuit components at the ultimate size limit. However, interpretation and analysis of the large, stochastic…

Mesoscale and Nanoscale Physics · Physics 2020-08-06 Nathan D. Bamberger , Jeffrey A. Ivie , Keshaba N. Parida , Dominic V. McGrath , Oliver L. A. Monti

scRNA-seq clustering is a critical task for analyzing single-cell RNA sequencing (scRNA-seq) data, as it groups cells with similar gene expression profiles. Transformers, as powerful foundational models, have been applied to scRNA-seq…

Machine Learning · Computer Science 2026-02-10 Zhuomin Liang , Liang Bai , Xian Yang

Multi-view clustering has attracted much attention thanks to the capacity of multi-source information integration. Although numerous advanced methods have been proposed in past decades, most of them generally overlook the significance of…

Computer Vision and Pattern Recognition · Computer Science 2023-05-08 Rui Chen , Yongqiang Tang , Wensheng Zhang , Wenlong Feng

Single-cell RNA sequencing technologies have revolutionized our understanding of cellular heterogeneity, yet computational methods often struggle to balance performance with biological interpretability. Embedded topic models have been…

Machine Learning · Computer Science 2025-12-08 Hegang Chen , Yuyin Lu , Yifan Zhao , Zhiming Dai , Fu Lee Wang , Qing Li , Yanghui Rao , Yue Li

Single-cell RNA-Sequencing (scRNA-Seq) is a revolutionary technique for discovering and describing cell types in heterogeneous tissues, yet its measurement of expression often suffers from large systematic bias. A major source of this bias…

Quantitative Methods · Quantitative Biology 2016-05-17 Martin Barron , Jun Li

Passenger clustering based on travel records is essential for transportation operators. However, existing methods cannot easily cluster the passengers due to the hierarchical structure of the passenger trip information, namely: each…

Machine Learning · Statistics 2023-06-27 Ziyue Li , Hao Yan , Chen Zhang , Andi Wang , Wolfgang Ketter , Lijun Sun , Fugee Tsung

Clustering multivariate data is a pervasive task in many applied problems, particularly in social studies and life science. Model-based approaches to clustering rely on mixture models, where each mixture component corresponds to the kernel…

Methodology · Statistics 2026-01-22 Laura Ferrini , Federico Castelletti

Recently, deep learning technology has been successfully introduced into Automatic Modulation Recognition (AMR) tasks. However, the success of deep learning is all attributed to the training on large-scale datasets. Such a large amount of…

Machine Learning · Computer Science 2024-08-07 Dongwei Xu , Jiajun Chen , Yao Lu , Tianhao Xia , Qi Xuan , Wei Wang , Yun Lin , Xiaoniu Yang

We consider the problem of model-based clustering in the presence of many correlated, mixed continuous and discrete variables, some of which may have missing values. Discrete variables are treated with a latent continuous variable approach…

Single-cell RNA sequencing (scRNA-seq) has made significant strides in unraveling the intricate cellular diversity within complex tissues. This is particularly critical in the brain, presenting a greater diversity of cell types than other…

Machine Learning · Computer Science 2023-10-05 Gyutaek Oh , Baekgyu Choi , Inkyung Jung , Jong Chul Ye

Crowd counting usually addressed by density estimation becomes an increasingly important topic in computer vision due to its widespread applications in video surveillance, urban planning, and intelligence gathering. However, it is…

Computer Vision and Pattern Recognition · Computer Science 2018-08-21 Ze Wang , Zehao Xiao , Kai Xie , Qiang Qiu , Xiantong Zhen , Xianbin Cao

Single-cell multi-omics (scMulti-omics) refers to the paired multimodal data, such as Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq), where the regulation of each cell was measured from different modalities, i.e.…

Machine Learning · Computer Science 2024-10-18 Dian Meng , Bohao Xing , Xinlei Huang , Yanran Liu , Yijun Zhou , Yongjun xiao , Zitong Yu , Xubin Zheng

The Dirichlet Process (DP) mixture model has become a popular choice for model-based clustering, largely because it allows the number of clusters to be inferred. The sequential updating and greedy search (SUGS) algorithm (Wang and Dunson,…

Methodology · Statistics 2018-10-15 Oliver M. Crook , Laurent Gatto , Paul D. W. Kirk

In the realm of unsupervised learning, Bayesian nonparametric mixture models, exemplified by the Dirichlet Process Mixture Model (DPMM), provide a principled approach for adapting the complexity of the model to the data. Such models are…

Machine Learning · Computer Science 2022-04-20 Or Dinari , Raz Zamir , John W. Fisher , Oren Freifeld

Dataset Distillation aims to synthesize compact datasets that can approximate the training efficacy of large-scale real datasets, offering an efficient solution to the increasing computational demands of modern deep learning. Recently,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Chenru Wang , Yunyi Chen , Zijun Yang , Joey Tianyi Zhou , Chi Zhang

Single-cell RNA sequencing (scRNA-seq) enables single-cell transcriptomic profiling, revealing cellular heterogeneity and rare populations. Recent deep learning models like Geneformer and Mouse-Geneformer perform well on tasks such as…

Genomics · Quantitative Biology 2025-07-11 Yuki Nishio , Takayoshi Yamashita , Keita Ito , Tsubasa Hirakawa , Hironobu Fujiyoshi

Current SMILES-based diffusion models for molecule generation typically support only unimodal constraint. They inject conditioning signals at the start of the training process and require retraining a new model from scratch whenever the…

Machine Learning · Computer Science 2025-08-21 Yunzhe Zhang , Yifei Wang , Khanh Vinh Nguyen , Pengyu Hong
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