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Functional brain connectivity, as revealed through distant correlations in the signals measured by functional Magnetic Resonance Imaging (fMRI), is a promising source of biomarkers of brain pathologies. However, establishing and using…

We conduct an imaging genetics study to explore how effective brain connectivity in the default mode network (DMN) may be related to genetics within the context of Alzheimer's disease and mild cognitive impairment. We develop an analysis of…

Neurons and Cognition · Quantitative Biology 2020-06-03 Yunlong Nie , Eugene Opoku , Laila Yasmin , Yin Song , Jie Wang , Sidi Wu , Vanessa Scarapicchia , Jodie Gawryluk , Liangliang Wang , Jiguo Cao , Farouk S. Nathoo

Understanding the relationship between the dynamics of neural processes and the anatomical substrate of the brain is a central question in neuroscience. On the one hand, modern neuroimaging technologies, such as diffusion tensor imaging,…

Resting-state functional magnetic resonance imaging (rs-fMRI) is a noninvasive technique pivotal for understanding human neural mechanisms of intricate cognitive processes. Most rs-fMRI studies compute a single static functional…

Neurons and Cognition · Quantitative Biology 2025-02-25 Bishal Thapaliya , Robyn Miller , Jiayu Chen , Yu-Ping Wang , Esra Akbas , Ram Sapkota , Bhaskar Ray , Pranav Suresh , Santosh Ghimire , Vince Calhoun , Jingyu Liu

Effective connectivity analysis provides an understanding of the functional organization of the brain by studying how activated regions influence one other. We propose a nonparametric Bayesian approach to model effective connectivity…

Applications · Statistics 2011-07-22 Sourabh Bhattacharya , Ranjan Maitra

Data produced by resting-state functional Magnetic Resonance Imaging are widely used to infer brain functional connectivity networks. Such networks correlate neural signals to connect brain regions, which consist in groups of dependent…

Methodology · Statistics 2023-12-05 Hanâ Lbath , Alexander Petersen , Sophie Achard

Background: Recent studies have indicated that functional connectivity is dynamic even during rest. A common approach to modeling the dynamic functional connectivity in whole-brain resting-state fMRI is to compute the correlation between…

Neurons and Cognition · Quantitative Biology 2019-11-05 Shih-Gu Huang , S. Balqis Samdin , Chee-Ming Ting , Hernando Ombao , Moo K. Chung

The objective of this paper is to provide a temporal dynamic model for resting state functional Magnetic Resonance Imaging (fMRI) trajectory to predict future brain images based on the given sequence. To this end, we came up with the model…

Signal Processing · Electrical Eng. & Systems 2020-11-17 Zheyu Wen

In this paper, we consider stable stochastic linear systems modeling whole-brain resting-state dynamics. We parametrize the state matrix of the system (effective connectivity) in terms of its steady-state covariance matrix (functional…

Systems and Control · Electrical Eng. & Systems 2023-10-12 Umberto Casti , Giacomo Baggio , Danilo Benozzo , Sandro Zampieri , Alessandra Bertoldo , Alessandro Chiuso

Dynamic functional connectivity (FC) has in recent years become a topic of interest in the neuroimaging community. Several models and methods exist for both functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), and…

Resting state functional connectivity estimates from MRI measures has become a promising tool to characterize human brain networks. There are, however, limitations in the method since several sources of errors have been seen to…

Neurons and Cognition · Quantitative Biology 2016-03-04 Pouya Ghaemmaghami

We present a didactic introduction to spectral Dynamic Causal Modelling (DCM), a Bayesian state-space modelling approach used to infer effective connectivity from non-invasive neuroimaging data. Spectral DCM is currently the most widely…

Neurons and Cognition · Quantitative Biology 2023-09-07 Leonardo Novelli , Karl Friston , Adeel Razi

Functional magnetic resonance imaging (fMRI) provides an indirect measurement of neuronal activity via hemodynamic responses that vary across brain regions and individuals. Ignoring this hemodynamic variability can bias downstream…

Image and Video Processing · Electrical Eng. & Systems 2026-01-26 William Consagra , Eardi Lila

Resting-state functional MRI (rs-fMRI) is widely used to noninvasively study human brain networks. Network functional connectivity is often estimated by calculating the timeseries correlation between blood-oxygen-level dependent (BOLD)…

Quantitative Methods · Quantitative Biology 2017-01-25 Nan Xu , R. Nathan Spreng , Peter C. Doerschuk

In this work we focus on examination and comparison of whole-brain functional connectivity patterns measured with fMRI across experimental conditions. Direct examination and comparison of condition-specific matrices is challenging due to…

Applications · Statistics 2013-01-02 Svetlana V. Shinkareva , Vladimir Gudkov , Jing Wang

Understanding the evolution of brain functional networks over time is of great significance for the analysis of cognitive mechanisms and the diagnosis of neurological diseases. Existing methods often have difficulty in capturing the…

Machine Learning · Computer Science 2025-10-30 Tianqi Guo , Liping Chen , Ciyuan Peng , Jingjing Zhou , Jing Ren

The Blood-Oxygen-Level-Dependent (BOLD) signal of resting-state fMRI (rs-fMRI) records the temporal dynamics of intrinsic functional networks in the brain. However, existing deep learning methods applied to rs-fMRI either neglect the…

Machine Learning · Computer Science 2021-06-30 Soham Gadgil , Qingyu Zhao , Adolf Pfefferbaum , Edith V. Sullivan , Ehsan Adeli , Kilian M. Pohl

The brain may be thought of as a many-body architecture with a spatio-temporal dynamics described by neuronal structures. The oscillatory nature of brain activity allows these structures (nodes) to be described as a set of coupled…

Neurons and Cognition · Quantitative Biology 2021-02-03 J. Mendoza-Ruiz , C. E. Alonso-Malaver , M. Valderrama , O. A. Rosso , J. H. Martínez

Inferring a binary connectivity graph from resting-state fMRI data for a single subject requires making several methodological choices and assumptions that can significantly affect the results. In this study, we investigate the robustness…

Methodology · Statistics 2025-03-20 Alice Chevaux , Ali Fahkar , Kévin Polisano , Irène Gannaz , Sophie Achard

Recent studies on analyzing dynamic brain connectivity rely on sliding-window analysis or time-varying coefficient models which are unable to capture both smooth and abrupt changes simultaneously. Emerging evidence suggests state-related…

Applications · Statistics 2019-07-04 Chee-Ming Ting , Hernando Ombao , S. Balqis Samdin , Sh-Hussain Salleh