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In the study of shapes of human organs using computational anatomy, variations are found to arise from inter-subject anatomical differences, disease-specific effects, and measurement noise. This paper introduces a stochastic model for…

Computer Vision and Pattern Recognition · Computer Science 2016-12-19 Alexis Arnaudon , Darryl D. Holm , Akshay Pai , Stefan Sommer

Modelling deformation of anatomical objects observed in medical images can help describe disease progression patterns and variations in anatomy across populations. We apply a stochastic generalisation of the Large Deformation Diffeomorphic…

Statistics Theory · Mathematics 2018-12-14 Line Kühnel , Alexis Arnaudon , Tom Fletcher , Stefan Sommer

Models of stochastic image deformation allow study of time-continuous stochastic effects transforming images by deforming the image domain. Applications include longitudinal medical image analysis with both population trends and random…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Alexander Christgau , Alexis Arnaudon , Stefan Sommer

Matching of images and analysis of shape differences is traditionally pursued by energy minimization of paths of deformations acting to match the shape objects. In the Large Deformation Diffeomorphic Metric Mapping (LDDMM) framework,…

Computer Vision and Pattern Recognition · Computer Science 2018-10-23 Alexis Arnaudon , Darryl Holm , Stefan Sommer

Anatomy is undergoing a renaissance driven by availability of large digital data sets generated by light microscopy. A central computational task is to map individual data volumes to standardized templates. This is accomplished by…

Image and Video Processing · Electrical Eng. & Systems 2018-09-19 Daniel J. Tward , Partha Mitra , Michael I. Miller

In deformable registration, the geometric framework - large deformation diffeomorphic metric mapping or LDDMM, in short - has inspired numerous techniques for comparing, deforming, averaging and analyzing shapes or images. Grounded in…

Artificial Intelligence · Computer Science 2022-05-11 Boulbaba Ben Amor , Sylvain Arguillère , Ling Shao

We introduce a new framework to analyze shape descriptors that capture the geometric features of an ensemble of point clouds. At the core of our approach is the point of view that the data arises as sampled recordings from a metric…

Statistics Theory · Mathematics 2024-09-11 Anne van Delft , Andrew J. Blumberg

In computational anatomy, the Large Deformation Diffeomorphic Metric Mapping (LDDMM) framework has become a central tool for modeling smooth, invertible transformations between shapes such as curves or landmarks. In this paper, we extend…

Differential Geometry · Mathematics 2025-11-19 Rayane Mouhli , Thomas Pierron

Accurate tracking of an anatomical landmark over time has been of high interests for disease assessment such as minimally invasive surgery and tumor radiation therapy. Ultrasound imaging is a promising modality benefiting from low-cost and…

Computer Vision and Pattern Recognition · Computer Science 2023-02-01 Zhihua Liu , Bin Yang , Yan Shen , Xuejun Ni , Huiyu Zhou

We innovatively propose a flexible and consistent face alignment framework, LDDMM-Face, the key contribution of which is a deformation layer that naturally embeds facial geometry in a diffeomorphic way. Instead of predicting facial…

Computer Vision and Pattern Recognition · Computer Science 2021-08-03 Huilin Yang , Junyan Lyu , Pujin Cheng , Xiaoying Tang

We introduce a novel conditional stochastic interpolant framework for generative modeling of three-dimensional shapes. The method builds on a recent LDDMM-based registration approach to learn the conditional drift between geometries. By…

Machine Learning · Statistics 2026-03-31 Sarah Katz , Francesco Romor , Jia-Jie Zhu , Alfonso Caiazzo

In the pattern matching approach to imaging science, the process of \emph{metamorphosis} in template matching with dynamical templates was introduced in \cite{ty05b}. In \cite{HoTrYo2009} the metamorphosis equations of \cite{ty05b} were…

Mathematical Physics · Physics 2017-05-30 Darryl D. Holm

Advances in the development of largely automated microscopy methods such as MERFISH for imaging cellular structures in mouse brains are providing spatial detection of micron resolution gene expression. While there has been tremendous…

Numerical Analysis · Mathematics 2022-12-20 Michael I Miller , Alain Trouvé , Laurent Younes

Clinical investigations of anatomy's structural changes over time could greatly benefit from population-level quantification of shape, or spatiotemporal statistic shape modeling (SSM). Such a tool enables characterizing patient organ cycles…

Machine Learning · Computer Science 2022-09-08 Jadie Adams , Nawazish Khan , Alan Morris , Shireen Elhabian

Many systems in physics, engineering, and biology exhibit multiscale stochastic dynamics, where low-dimensional slow variables evolve under the influence of high-dimensional fast processes. In practice, observations are often limited to a…

Machine Learning · Statistics 2026-05-12 Anan Saha , Arnab Ganguly

We investigate the potential of stochastic neural networks for learning effective waveform-based acoustic models. The waveform-based setting, inherent to fully end-to-end speech recognition systems, is motivated by several comparative…

Machine Learning · Statistics 2021-08-17 Dino Oglic , Zoran Cvetkovic , Peter Sollich

We present a method to predict image deformations based on patch-wise image appearance. Specifically, we design a patch-based deep encoder-decoder network which learns the pixel/voxel-wise mapping between image appearance and registration…

Computer Vision and Pattern Recognition · Computer Science 2016-07-11 Xiao Yang , Roland Kwitt , Marc Niethammer

Stochastically evolving geometric systems are studied in shape analysis and computational anatomy for modelling random evolutions of human organ shapes. The notion of geodesic paths between shapes is central to shape analysis and has a…

Numerical Analysis · Mathematics 2022-12-01 Alexis Arnaudon , Frank van der Meulen , Moritz Schauer , Stefan Sommer

The Large Deformation Diffeomorphic Metric Mapping (LDDMM) or flow of diffeomorphism is a classical framework in the field of shape spaces and is widely applied in mathematical imaging and computational anatomy. Essentially, it equips a…

Numerical Analysis · Mathematics 2026-02-27 Benedikt Wirth

We develop a continuous-time model for the long-term dynamics of adaptive stochastic optimization, focusing on bias-corrected Adam-type methods. Starting from a finite-sum setting, we identify a canonical scaling of learning rates, decay…

Analysis of PDEs · Mathematics 2026-04-02 Kaj Nyström
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