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Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any…

Methodology · Statistics 2011-11-16 Jianqing Fan , Xu Han , Weijie Gu

We study the problem of independence testing given independent and identically distributed pairs taking values in a $\sigma$-finite, separable measure space. Defining a natural measure of dependence $D(f)$ as the squared $L^2$-distance…

Statistics Theory · Mathematics 2020-11-09 Thomas B. Berrett , Ioannis Kontoyiannis , Richard J. Samworth

Statistical inferences for sample correlation matrices are important in high dimensional data analysis. Motivated by this, this paper establishes a new central limit theorem (CLT) for a linear spectral statistic (LSS) of high dimensional…

Statistics Theory · Mathematics 2014-11-04 Jiti Gao , Xiao Han , Guangming Pan , Yanrong Yang

Independence testing is a classical statistical problem that has been extensively studied in the batch setting when one fixes the sample size before collecting data. However, practitioners often prefer procedures that adapt to the…

Machine Learning · Statistics 2025-05-21 Aleksandr Podkopaev , Patrick Blöbaum , Shiva Prasad Kasiviswanathan , Aaditya Ramdas

We propose an independence test for random variables valued into metric spaces by using a test statistic obtained from appropriately centering and rescaling the squared Hilbert-Schmidt norm of the usual empirical estimator of normalized…

Statistics Theory · Mathematics 2022-11-11 Terence Kevin Manfoumbi Djonguet , Guy Martial Nkiet

Statistical dependence between hypotheses poses a significant challenge to the stability of large scale multiple hypotheses testing. Ignoring it often results in an unacceptably large spread in the false positive proportion even though the…

Methodology · Statistics 2018-10-15 Sairam Rayaprolu , Zhiyi Chi

We propose a two-sample test for high-dimensional means that requires neither distributional nor correlational assumptions, besides some weak conditions on the moments and tail properties of the elements in the random vectors. This…

Methodology · Statistics 2019-04-17 Kaijie Xue , Fang Yao

Testing for independence between graphs is a problem that arises naturally in social network analysis and neuroscience. In this paper, we address independence testing for inhomogeneous Erd\H{o}s-R\'{e}nyi random graphs on the same vertex…

Methodology · Statistics 2023-04-19 Yukun Song , Carey E. Priebe , Minh Tang

We consider the problem of independence testing for two univariate random variables in a sequential setting. By leveraging recent developments on safe, anytime-valid inference, we propose a test with time-uniform type I error control and…

Methodology · Statistics 2024-01-29 Alexander Henzi , Michael Law

Distance correlation is a novel class of multivariate dependence measure, taking positive values between 0 and 1, and applicable to random vectors of arbitrary dimensions, not necessarily equal. It offers several advantages over the…

Computation · Statistics 2024-05-06 Blanca E. Monroy-Castillo , M. A , Jácome , Ricardo Cao

Many high-dimensional hypothesis tests aim to globally examine marginal or low-dimensional features of a high-dimensional joint distribution, such as testing of mean vectors, covariance matrices and regression coefficients. This paper…

Statistics Theory · Mathematics 2020-02-04 Yinqiu He , Gongjun Xu , Chong Wu , Wei Pan

We provide a unified framework for independence and mean independence tests based on the Hilbert-Schmidt independence criterion, extending some previous results in the literature to hold in general topological spaces. We also present a…

Methodology · Statistics 2026-05-01 Daniel Diz-Castro , Manuel Febrero-Bande , Wenceslao González-Manteiga

Large-scale hypothesis testing has become a ubiquitous problem in high-dimensional statistical inference, with broad applications in various scienfitic disciplines. One relevant application is constituted by imaging mass spectrometry (IMS)…

Methodology · Statistics 2021-08-19 Vladimir Vutov , Thorsten Dickhaus

Distance correlation is a new measure of dependence between random vectors. Distance covariance and distance correlation are analogous to product-moment covariance and correlation, but unlike the classical definition of correlation,…

Statistics Theory · Mathematics 2008-12-18 Gábor J. Székely , Maria L. Rizzo , Nail K. Bakirov

We apply the concept of distance covariance for testing independence of two long-range dependent time series. As test statistic we propose a linear combination of empirical distance cross-covariances. We derive the asymptotic distribution…

Statistics Theory · Mathematics 2026-01-28 Annika Betken , Herold Dehling

Testing two potentially multivariate variables for statistical dependence on the basis finite samples is a fundamental statistical challenge. Here we explore a family of tests that adapt to the complexity of the relationship between the…

Machine Learning · Statistics 2020-10-23 Baihan Lin , Nikolaus Kriegeskorte

Due to the lack of a canonical ordering in ${\mathbb R}^d$ for $d>1$, defining multivariate generalizations of the classical univariate ranks has been a long-standing open problem in statistics. Optimal transport has been shown to offer a…

Statistics Theory · Mathematics 2024-09-11 Hongjian Shi , Mathias Drton , Marc Hallin , Fang Han

Particularly in genomics, but also in other fields, it has become commonplace to undertake highly multiple Student's $t$-tests based on relatively small sample sizes. The literature on this topic is continually expanding, but the main…

Statistics Theory · Mathematics 2010-10-11 Peter Hall , Qiying Wang

The problem of measuring conditional dependence between two random phenomena arises when a third one (a confounder) has a potential influence on the amount of information between them. A typical issue in this challenging problem is the…

Machine Learning · Statistics 2025-03-12 Ferran de Cabrera , Marc Vilà-Insa , Jaume Riba

This paper studies the construction of p-values for nonparametric outlier detection, taking a multiple-testing perspective. The goal is to test whether new independent samples belong to the same distribution as a reference data set or are…

Methodology · Statistics 2024-03-12 Stephen Bates , Emmanuel Candès , Lihua Lei , Yaniv Romano , Matteo Sesia