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Related papers: SMILES Enumeration as Data Augmentation for Neural…

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Ensembling is a simple and popular technique for boosting evaluation performance by training multiple models (e.g., with different initializations) and aggregating their predictions. This approach is commonly reserved for the largest…

Machine Learning · Computer Science 2020-05-05 Dan Kondratyuk , Mingxing Tan , Matthew Brown , Boqing Gong

A proof-of-concept framework for identifying molecules of unknown elemental composition and structure using experimental rotational data and probabilistic deep learning is presented. Using a minimal set of input data determined…

Chemical Physics · Physics 2020-07-01 Michael C. McCarthy , Kin Long Kelvin Lee

Fine-tuning large language models (LLMs) is often constrained by the computational costs of processing massive datasets. We propose \textbf{QLESS} (Quantized Low-rank Gradient Similarity Search), which integrates gradient quantization with…

Modern language models (LMs) are trained in an autoregressive manner, conditioned only on the prefix. In contrast, sequence labeling (SL) tasks assign labels to each individual input token, naturally benefiting from bidirectional context.…

Computation and Language · Computer Science 2026-01-27 Matija Luka Kukić , Marko Čuljak , David Dukić , Martin Tutek , Jan Šnajder

Optical chemical structure recognition (OCSR) systems aim to extract the molecular structure information, usually in the form of molecular graph or SMILES, from images of chemical molecules. While many tools have been developed for this…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 Ching Ting Leung , Yufan Chen , Hanyu Gao

Multimodal large language models (MLLMs) achieve strong performance by jointly processing inputs from multiple modalities, such as vision, audio, and language. However, building such models or extending them to new modalities often requires…

Machine Learning · Computer Science 2026-03-24 Md Kaykobad Reza , Ameya Patil , Edward Ayrapetian , M. Salman Asif

Biological screens are plagued by false positive hits resulting from aggregation. Thus, methods to triage small colloidally aggregating molecules (SCAMs) are in high demand. Herein, we disclose a bespoke machine-learning tool to confidently…

Quantitative Methods · Quantitative Biology 2021-05-04 Kuan Lee , Ann Yang , Yen-Chu Lin , Daniel Reker , Goncalo J. L. Bernardes , Tiago Rodrigues

Large language models (LLMs) have shown promising efficacy across various tasks, becoming powerful tools in numerous aspects of human life. However, Transformer-based LLMs suffer a performance degradation when modeling long-term contexts…

Computation and Language · Computer Science 2026-03-23 Weiyao Luo , Suncong Zheng , Heming Xia , Weikang Wang , Yan Lei , Tianyu Liu , Shuang Chen , Zhifang Sui

Recent research has explored how Language Models (LMs) can be used for feature representation and prediction in tabular machine learning tasks. This involves employing text serialization and supervised fine-tuning (SFT) techniques. Despite…

Computation and Language · Computer Science 2024-06-21 Kyoka Ono , Simon A. Lee

A central task in computational drug discovery is to construct models from known active molecules to find further promising molecules for subsequent screening. However, typically only very few active molecules are known. Therefore, few-shot…

Masked Image Modeling (MIM) has emerged as a promising approach for Self-Supervised Learning (SSL) of visual representations. However, the out-of-the-box performance of MIMs is typically inferior to competing approaches. Most users cannot…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Marcin Przewięźlikowski , Randall Balestriero , Wojciech Jasiński , Marek Śmieja , Bartosz Zieliński

The application of visual instruction tuning and other post-training techniques has significantly enhanced the capabilities of Large Language Models (LLMs) in visual understanding, enriching Vision-Language Models (VLMs) with more…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Mingjie Xu , Andrew Estornell , Hongzheng Yang , Yuzhi Zhao , Zhaowei Zhu , Qi Xuan , Jiaheng Wei

Machine learning techniques have recently been adopted in various applications in medicine, biology, chemistry, and material engineering. An important task is to predict the properties of molecules, which serves as the main subroutine in…

Machine Learning · Computer Science 2019-11-12 Shengchao Liu , Mehmet Furkan Demirel , Yingyu Liang

In this paper we determine how multi-layer ensembling improves performance on multilingual intent classification. We develop a novel multi-layer ensembling approach that ensembles both different model initializations and different model…

Computation and Language · Computer Science 2018-06-22 Charles Costello , Ruixi Lin , Vishwas Mruthyunjaya , Bettina Bolla , Charles Jankowski

Accurately predicting molecular properties is a challenging but essential task in drug discovery. Recently, many mono-modal deep learning methods have been successfully applied to molecular property prediction. However, the inherent…

Machine Learning · Computer Science 2024-09-16 Xiaohua Lu , Liangxu Xie , Lei Xu , Rongzhi Mao , Shan Chang , Xiaojun Xu

Large genomic and imaging datasets can be used to train models that learn meaningful representations of cellular systems. Across domains, model performance improves predictably with dataset size and compute budget, providing a basis for…

Quantitative Methods · Quantitative Biology 2026-02-23 Gokul Gowri , Igor Sadalski , Dan Raviv , Peng Yin , Jonathan Rosenfeld , Allon M. Klein

Pre-trained segmentation models are a powerful and flexible tool for segmenting images. Recently, this trend has extended to medical imaging. Yet, often these methods only produce a single prediction for a given image, neglecting inherent…

Computer Vision and Pattern Recognition · Computer Science 2025-03-14 Benjamin Towle , Xin Chen , Ke Zhou

Stochastic simulation can make the molecular processes of cellular control more vivid than the traditional differential-equation approach by generating typical system histories instead of just statistical measures such as the mean and…

Subcellular Processes · Quantitative Biology 2018-09-18 Kevin Y. Chen , Daniel M. Zuckerman , Philip C. Nelson

We propose Masked Siamese Networks (MSN), a self-supervised learning framework for learning image representations. Our approach matches the representation of an image view containing randomly masked patches to the representation of the…

Lexical Simplification (LS) methods use a three-step pipeline: complex word identification, substitute generation, and substitute ranking, each with separate evaluation datasets. We found large language models (LLMs) can simplify sentences…

Computation and Language · Computer Science 2025-01-28 Jipeng Qiang , Minjiang Huang , Yi Zhu , Yunhao Yuan , Chaowei Zhang , Xiaoye Ouyang
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