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Normative modeling has recently been introduced as a promising approach for modeling variation of neuroimaging measures across individuals in order to derive biomarkers of psychiatric disorders. Current implementations rely on Gaussian…

Machine Learning · Statistics 2019-04-16 Seyed Mostafa Kia , Andre F. Marquand

Factor analysis (FA) is a statistical tool for studying how observed variables with some mutual dependences can be expressed as functions of mutually independent unobserved factors, and it is widely applied throughout the psychological,…

Machine Learning · Statistics 2023-06-01 Alex Markham , Mingyu Liu , Bryon Aragam , Liam Solus

Sample average approximation (SAA) is a widely popular approach to data-driven decision-making under uncertainty. Under mild assumptions, SAA is both tractable and enjoys strong asymptotic performance guarantees. Similar guarantees,…

Optimization and Control · Mathematics 2016-11-03 Dimitris Bertsimas , Vishal Gupta , Nathan Kallus

An important goal of medical imaging is to be able to precisely detect patterns of disease specific to individual scans; however, this is challenged in brain imaging by the degree of heterogeneity of shape and appearance. Traditional…

Sample average approximation (SAA), a popular method for tractably solving stochastic optimization problems, enjoys strong asymptotic performance guarantees in settings with independent training samples. However, these guarantees are not…

Optimization and Control · Mathematics 2021-12-13 Yafei Wang , Bo Pan , Wei Tu , Peng Liu , Bei Jiang , Chao Gao , Wei Lu , Shangling Jui , Linglong Kong

Methods for analyzing representations in neural systems have become a popular tool in both neuroscience and mechanistic interpretability. Having measures to compare how similar activations of neurons are across conditions, architectures,…

Machine Learning · Computer Science 2024-12-24 Quentin Guilhot , Michał Wójcik , Jascha Achterberg , Rui Ponte Costa

Consider a researcher estimating the parameters of a regression function based on data for all 50 states in the United States or on data for all visits to a website. What is the interpretation of the estimated parameters and the standard…

Statistics Theory · Mathematics 2019-06-25 Alberto Abadie , Susan Athey , Guido W. Imbens , Jeffrey M. Wooldridge

Discriminative analysis in neuroimaging by means of deep/machine learning techniques is usually tested with validation techniques, whereas the associated statistical significance remains largely under-developed due to their computational…

ANOVA Simultaneous Component Analysis (ASCA) is the current state-of-theart chemometric tool for analyzing and interpreting high-dimensional experimental data from a Design of Experiment (DoE). Being a multivariate extension of the ANOVA,…

Methodology · Statistics 2026-05-20 José Camacho , Jokin Ezenarro , Daniel Schorn-García , Johan A. Westerhuis

Medical imaging provides many valuable clues involving anatomical structure and pathological characteristics. However, image degradation is a common issue in clinical practice, which can adversely impact the observation and diagnosis by…

Image and Video Processing · Electrical Eng. & Systems 2023-12-05 Heng Li , Ziqin Lin , Zhongxi Qiu , Zinan Li , Huazhu Fu , Yan Hu , Jiang Liu

Synthetic data is becoming increasingly integral in data-scarce fields such as medical imaging, serving as a substitute for real data. However, its inherent statistical characteristics can significantly impact downstream tasks, potentially…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Krishan Agyakari Raja Babu , Rachana Sathish , Mrunal Pattanaik , Rahul Venkataramani

Representational similarity analysis (RSA) is a multivariate technique to investigate cortical representations of objects or constructs. While avoiding ill-posed matrix inversions that plague multivariate approaches in the presence of many…

Methodology · Statistics 2021-12-03 Roberto Viviani

The growing adoption of IoT systems in industries like transportation, banking, healthcare, and smart energy has increased reliance on sensor networks. However, anomalies in sensor readings can undermine system reliability, making real-time…

Signal Processing · Electrical Eng. & Systems 2025-06-02 Tanish Baranwal , Arnab Das , Srihari Varada , Santanu Das , Mohammad R. Haider

Purpose: To systematically investigate the influence of various data consistency layers, (semi-)supervised learning and ensembling strategies, defined in a $\Sigma$-net, for accelerated parallel MR image reconstruction using deep learning.…

Image and Video Processing · Electrical Eng. & Systems 2019-12-20 Kerstin Hammernik , Jo Schlemper , Chen Qin , Jinming Duan , Ronald M. Summers , Daniel Rueckert

Cognitive brain imaging is accumulating datasets about the neural substrate of many different mental processes. Yet, most studies are based on few subjects and have low statistical power. Analyzing data across studies could bring more…

Machine Learning · Statistics 2021-05-20 Arthur Mensch , Julien Mairal , Bertrand Thirion , Gaël Varoquaux

Molecular simulations and biophysical experiments can be used to provide independent and complementary insights into the molecular origin of biological processes. A particularly useful strategy is to use molecular simulations as a modelling…

Chemical Physics · Physics 2019-12-10 Simone Orioli , Andreas Haahr Larsen , Sandro Bottaro , Kresten Lindorff-Larsen

Design-based simulations - procedures that hold realized outcomes fixed and generate variation by resampling treatment assignment or shocks - are widely used in both methodological and applied work to assess inference procedures. This paper…

Econometrics · Economics 2026-03-13 Bruno Ferman

Online controlled experiments face growing challenges from overlapping tests on shared traffic, where interactions between concurrent experiments obscure insights into feature combinations and produce effect estimates that do not correspond…

Methodology · Statistics 2026-04-21 Reza Hosseini

How should researchers analyze randomized experiments in which the main outcome is latent and measured in multiple ways but each measure contains some degree of error? We first identify a critical study-specific noncomparability problem in…

Econometrics · Economics 2026-01-13 Jiawei Fu , Donald P. Green

Chemical separations data are typically analysed in the time domain using methods that integrate the discrete elution bands. Integrating the same chemical components across several samples must account for retention time drift over the…

Methodology · Statistics 2024-10-14 Michael Sorochan Armstrong , José Camacho