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Epilepsy is a dynamic and complex neurological disease affecting about 1% of the worldwide population, among which 30% of the patients are drug-resistant. Epilepsy is characterized by recurrent episodes of paroxysmal neural discharges (the…
Synchronization is a ubiquitous phenomenon in nature. Although it is necessary for the functioning of many systems, too much synchronization can also be detrimental, e.g., (partially) synchronized brain patterns support high-level cognitive…
Intracranial recordings in epilepsy patients are increasingly utilized to gain insight into the electrophysiological mechanisms of human cognition. There are currently several practical limitations to conducting research with these…
Epilepsy is a well-known neuronal disorder that can be identified by interpretation of the electroencephalogram (EEG) signal. Usually, the length of an EEG signal is quite long which is challenging to interpret manually. In this work, we…
Epilepsy is a chronic neurological disorder affecting more than 65 million people worldwide and manifested by recurrent unprovoked seizures. The unpredictability of seizures not only degrades the quality of life of the patients, but it can…
Recent advances in control theory yield closed-loop neurostimulations for suppressing epileptiform seizures. These advances are illustrated by computer experiments which are easy to implement and to tune. The feedback synthesis is provided…
A universal approach is proposed for suppression of collective synchrony in a large population of interacting rhythmic units. We demonstrate that provided that the internal coupling is weak, stabilization of overall oscillations with…
Suppression of excessively synchronous beta-band oscillatory activity in the brain is believed to suppress hypokinetic motor symptoms of Parkinson's disease. Recently, a lot of interest has been devoted to desynchronizing delayed feedback…
Transient or partial synchronization can be used to do computations, although a fully synchronized network is frequently related to epileptic seizures. Here, we propose a homeostatic mechanism that is capable of maintaining a neuronal…
Seizure activity is a ubiquitous and pernicious pathophysiology that, in principle, should yield to mathematical treatments of (neuronal) ensemble dynamics - and therefore interventions on stochastic chaos. A seizure can be characterised as…
Epilepsy is a prevalent neurological disorder globally, impacting around 50 million people \cite{WHO_epilepsy_50million}. Epileptic seizures result from sudden abnormal electrical activity in the brain, which can be read as sudden and…
Epilepsy is a neurological disorder identified by sudden and recurrent seizures, which are believed to be accompanied by distinct changes in brain dynamics. Exploring the dynamic changes of brain network states during seizures can pave the…
Synchronous oscillatory dynamics is frequently observed in the human brain. We analyze the fine temporal structure of phase-locking in a realistic network model and match it with the experimental data from parkinsonian patients. We show…
Neurostimulation is a promising therapy for abating epileptic seizures. However, it is extremely difficult to identify optimal stimulation patterns experimentally. In this study human recordings are used to develop a functional 24 neuron…
Epilepsy is a disorder characterised by spontaneous, recurrent seizures. Both local and network abnormalities have been associated with epilepsy, and the exact processes generating seizures are thought to be heterogeneous and…
The electrical stimulation to the seizure onset zone (SOZ) serves as an efficient approach to seizure suppression. Recently, seizure dynamics have gained widespread attendance in its network propagation mechanisms. Compared with the direct…
Malfunctioning neurons in the brain sometimes operate synchronously, reportedly causing many neurological diseases, e.g. Parkinson's. Suppression and control of this collective synchronous activity are therefore of great importance for…
Epilepsy is the second most common brain disorder after migraine. Automatic detection of epileptic seizures can considerably improve the patients' quality of life. Current Electroencephalogram (EEG)-based seizure detection systems encounter…
Epilepsy is one of the most common and yet diverse set of chronic neurological disorders. This excessive or synchronous neuronal activity is termed seizure. Electroencephalogram signal processing plays a significant role in detection and…
Motivated by deep brain stimulation treatment of neural disorders such as Parkinson's disease, it has been proposed that desynchronization of neural oscillators can be achieved by maximizing the Lyapunov exponent of the phase difference…