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Mediation analysis seeks to identify and quantify the paths by which an exposure affects an outcome. Intermediate variables which are effected by the exposure and which effect the outcome are known as mediators. There exists extensive work…

Methodology · Statistics 2020-11-13 James P. Long , Ehsan Irajizad , James D. Doecke , Kim-Anh Do , Min Jin Ha

An essential goal of program evaluation and scientific research is the investigation of causal mechanisms. Over the past several decades, causal mediation analysis has been used in medical and social sciences to decompose the treatment…

Methodology · Statistics 2016-01-15 K. C. G. Chan , K. Imai , S. C. P. Yam , Z. Zhang

The aim of this study is to look at predicting whether a person will complete a drug and alcohol rehabilitation program and the number of times a person attends. The study is based on demographic data obtained from Substance Abuse and…

Machine Learning · Computer Science 2024-04-25 Karen Roberts-Licklider , Theodore Trafalis

The comparison of different medical treatments from observational studies or across different clinical studies is often biased by confounding factors such as systematic differences in patient demographics or in the inclusion criteria for…

Methodology · Statistics 2025-05-15 Ekkehard Glimm , Lillian Yau

Interference occurs when a unit's treatment (or exposure) affects another unit's outcome. In some settings, units may be grouped into clusters such that it is reasonable to assume that interference, if present, only occurs between…

Methodology · Statistics 2023-08-24 Chanhwa Lee , Donglin Zeng , Michael G. Hudgens

A crucial problem in learning disentangled image representations is controlling the degree of disentanglement during image editing, while preserving the identity of objects. In this work, we propose a simple yet effective model with the…

Machine Learning · Computer Science 2019-12-30 Zengjie Song , Oluwasanmi Koyejo , Jiangshe Zhang

We describe how the target trial framework can be used to plan and report analyses that attempt to answer causal questions by combining information from multiple, diverse sources. Such analyses may involve comparisons of treatments…

Methodology · Statistics 2026-05-26 Lawson Ung , Miguel A. Hernán , Issa J. Dahabreh

Mediation analysis breaks down the causal effect of a treatment on an outcome into an indirect effect, acting through a third group of variables called mediators, and a direct effect, operating through other mechanisms. Mediation analysis…

Applications · Statistics 2025-05-13 Judith Abécassis , Houssam Zenati , Sami Boumaïza , Julie Josse , Bertrand Thirion

Identifying causal effects in the presence of unmeasured variables is a fundamental challenge in causal inference, for which proxy variable methods have emerged as a powerful solution. We contrast two major approaches in this framework: (1)…

Methodology · Statistics 2026-05-12 Helen Guo , Elizabeth L. Ogburn , Ilya Shpitser

With widening deployments of natural language processing (NLP) in daily life, inherited social biases from NLP models have become more severe and problematic. Previous studies have shown that word embeddings trained on human-generated…

Computation and Language · Computer Science 2021-12-13 Lei Ding , Dengdeng Yu , Jinhan Xie , Wenxing Guo , Shenggang Hu , Meichen Liu , Linglong Kong , Hongsheng Dai , Yanchun Bao , Bei Jiang

Models notoriously suffer from dataset biases which are detrimental to robustness and generalization. The identify-emphasize paradigm shows a promising effect in dealing with unknown biases. However, we find that it is still plagued by two…

Machine Learning · Computer Science 2022-11-29 Bowen Zhao , Chen Chen , Qian-Wei Wang , Anfeng He , Shu-Tao Xia

Machine learning models have achieved widespread success but often inherit and amplify historical biases, resulting in unfair outcomes. Traditional fairness methods typically impose constraints at the prediction level, without addressing…

Machine Learning · Statistics 2026-02-10 Enze Shi , Pankaj Bhagwat , Zhixian Yang , Linglong Kong , Bei Jiang

Mendelian randomization (MR) is a widely used tool for causal inference in the presence of unmeasured confounders, which uses single nucleotide polymorphisms (SNPs) as instrumental variables to estimate causal effects. However, SNPs often…

Methodology · Statistics 2025-04-29 Ruoyu Wang , Haoyu Zhang , Xihong Lin

We propose a unified class of generalized structural equation models (GSEMs) with data of mixed types in mediation analysis, including continuous, categorical, and count variables. Such models extend substantially the classical linear…

Methodology · Statistics 2023-12-05 Wei Hao , Canyi Chen , Peter X. -K. Song

Mediation analysis is widely used in health science research to evaluate the extent to which an intermediate variable explains an observed exposure-outcome relationship. However, the validity of analysis can be compromised when the exposure…

Methodology · Statistics 2025-03-06 Chao Cheng , Donna Spiegelman , Fan Li

Deep learning models can perform well in complex medical imaging classification tasks, even when basing their conclusions on spurious correlations (i.e. confounders), should they be prevalent in the training dataset, rather than on the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Amar Kumar , Nima Fathi , Raghav Mehta , Brennan Nichyporuk , Jean-Pierre R. Falet , Sotirios Tsaftaris , Tal Arbel

Causal mediation analysis seeks to investigate how the treatment effect of an exposure on outcomes is mediated through intermediate variables. Although many applications involve longitudinal data, the existing methods are not directly…

Applications · Statistics 2021-02-24 Shuxi Zeng , Stacy Rosenbaum , Elizabeth Archie , Susan Alberts , Fan Li

Disentangled representation learning aims to map independent factors of variation to independent representation components. On one hand, purely unsupervised approaches have proven successful on fully disentangled synthetic data, but fail to…

Machine Learning · Computer Science 2026-01-30 Alexandre Myara , Nicolas Bourriez , Thomas Boyer , Thomas Lemercier , Ihab Bendidi , Auguste Genovesio

Deep learning models have shown promise in improving diagnostic accuracy from chest X-rays, but they also risk perpetuating healthcare disparities when performance varies across demographic groups. In this work, we present a comprehensive…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Clemence Mottez , Louisa Fay , Maya Varma , Sophie Ostmeier , Curtis Langlotz

There has been widespread use of causal inference methods for the rigorous analysis of observational studies and to identify policy evaluations. In this article, we consider a class of generalized coarsened procedures for confounding. At a…

Methodology · Statistics 2025-07-04 Debashis Ghosh , Lei Wang