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We present a theory to investigate electro-kinetic behavior, namely, electrorotation and dielectrophoresis under alternating current (AC) applied fields for a pair of touching inhomogeneous colloidal particles and biological cells. These…

Soft Condensed Matter · Physics 2007-05-23 J. P. Huang , Mikko Karttunen , K. W. Yu , L. Dong , G. Q. Gu

We present a single, unified, multi-scale model to study the attachment\detachment dynamics of two deforming, near spherical cells, coated with binding ligands and subject to a slow, homogeneous shear flow in a viscous fluid medium. The…

Cell Behavior · Quantitative Biology 2015-04-23 Sarthok Sircar , Anthony J. Roberts

An action potential is typically described as a purely electrical change that propagates along the membrane of excitable cells. However, recent experiments have demonstrated that non-linear acoustic pulses that propagate along lipid…

Biological Physics · Physics 2018-01-08 Matan Mussel , Matthias F. Schneider

Cell motility is one of the most fundamental phenomena underlying biological processes that maintain living organisms alive. Here we introduce a simple model to describe the motility of cells which include not only time-correlated internal…

Biological Physics · Physics 2022-07-13 T. N. Azevedo , L. G. Rizzi

During epithelial wound healing, cell morphology near the healed wound and the healing rate vary strongly among different developmental stages even for a single species like \textit{Drosophila}. We develop deformable particle (DP) model…

Biological Physics · Physics 2024-02-23 Andrew T. Ton , Arthur K. MacKeith , Mark D. Shattuck , Corey S. O'Hern

Both action potentials and mechanosensitive signalling are an important communication mechanisms in plants. Considering an information theoretic framework, this paper explores the effective range of multiple action potentials for a long…

Molecular Networks · Quantitative Biology 2019-11-13 Hamdan Awan , Kareem Zeid , Raviraj S. Adve , Nigel Wallbridge , Carrol Plummer , Andrew W. Eckford

We reveal that the mechanical pulsation of locally synchronised particles is a generic route to propagate deformation waves. We consider a model of dense repulsive particles whose activity drives periodic change in size of each individual.…

Soft Condensed Matter · Physics 2023-12-12 Yiwei Zhang , Étienne Fodor

Microswimmers and active colloids often move in confined systems, including those involving interfaces. Such interfaces, especially at the microscale, may deform in response to the stresses of the flow created by the active particle. We…

Soft Condensed Matter · Physics 2026-01-14 Adam Hitin Bialus , Bhargav Rallabandi , Naomi Oppenheimer

The propagation of an action potential (AP) in a nerve fibre is accompanied by mechanical and thermal effects. In this paper an attempt is made to build up a mathematical model which couples the AP with a possible pressure wave (PW) in the…

Biological Physics · Physics 2018-07-24 Jüri Engelbrecht , Tanel Peets , Kert Tamm

Biological cells can actively tune their intracellular architecture according to their overall shape. Here we explore the rheological implication of such coupling in a minimal model of a dense cellular material where each cell exerts an…

Soft Condensed Matter · Physics 2022-04-13 Shao-Zhen Lin , Matthias Merkel , Jean-François Rupprecht

A new stimulation paradigm is presented for the stimulation of nerve cells by extracellular electric currents. In the new paradigm stimulation is achieved with the current spike induced by a voltage step whenever the voltage step is applied…

Other Quantitative Biology · Quantitative Biology 2016-03-08 Erich W. Schmid

On the basis of the model of the current flow through a single fibre, changes in the electric charge density over the myocardium are described. With the use of relevant analytic formulae, supported with numerical calculations, the…

Medical Physics · Physics 2007-05-23 Jerzy S. Janicki

We measure the dynamical mechanical properties of human red blood cells. Single cell response is measured with optical tweezers. We investigate both the stress relaxation following a fast deformation, and the effect of varying the strain…

Soft Condensed Matter · Physics 2009-11-13 Young-Zoon Yoon , Jurij Kotar , Gilwon Yoon , Pietro Cicuta

The action potential is widely considered a purely electrical phenomenon. However, one also finds mechanical and thermal changes that can be observed experimentally. In particular, nerve membranes become thicker and axons contract. The…

Neurons and Cognition · Quantitative Biology 2025-09-29 T. Heimburg

We present a continuum model of the coupling between cells and substrate that accounts for some of the observed substrate-stiffness dependence of cell properties. The cell is modeled as an elastic active gel, adapting recently developed…

Cell Behavior · Quantitative Biology 2015-05-28 Shiladitya Banerjee , M. Cristina Marchetti

The polarisation of cells and tissues is fundamental for tissue morphogenesis during biological development and regeneration. A deeper understanding of biological polarity pattern formation can be gained from the consideration of pattern…

Cell Behavior · Quantitative Biology 2017-10-23 Karl B. Hoffmann , Anja Voss-Böhme , Jochen C. Rink , Lutz Brusch

We present a deformation-dependent propulsion phenomenon for soft particles such as cells in microchannels. It is based on a broken time reversal symmetry generated by a fast forward and slow backward motion of a fluid which does not…

Soft Condensed Matter · Physics 2022-02-22 Winfried Schmidt , Andre Förtsch , Matthias Laumann , Walter Zimmermann

The motility of a fish keratocyte on a flat substrate exhibits two distinct regimes: the non-migrating and the migrating one. In both configurations the shape is fixed in time and, when the cell is moving, the velocity is constant in…

Cell Behavior · Quantitative Biology 2016-06-29 Davide Ambrosi , Anna Zanzottera

A hybrid 2D theoretical model is presented to describe thermoplastic deformation effects on silicon surfaces induced by single and multiple ultrashort pulsed laser irradiation in submelting conditions. An approximation of the Boltzmann…

Materials Science · Physics 2012-10-04 G. D. Tsibidis , E. Stratakis , K. E. Aifantis

Plant morphogenesis relies on dynamic growth deformations at the cell and tissue scales driven by osmotic fluxes. A mechanistic understanding of this phenomenon demands a physical framework that integrates cell imbibition, tissue mechanics,…

Biological Physics · Physics 2025-12-08 Hadrien Oliveri , Christophe Godin , Ibrahim Cheddadi