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A novel self-assembly strategy for polypeptide nanostructure design was presented in [Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments, Nature Chemical Biology 9 (2013) 362--366]. The first mathematical…

Combinatorics · Mathematics 2018-08-28 Gašper Fijavž , Tomaž Pisanski , Jernej Rus

In this paper, we introduce fundamental notions of homotopy theory, including homotopy excision and the Freudenthal suspension theorem. We then explore framed cobordism and its connection to stable homotopy groups of spheres through the…

Algebraic Topology · Mathematics 2025-03-17 Trishan Mondal

Controlling the topology of structures self-assembled from a set of heterogeneous building blocks is highly desirable for many applications, but is poorly understood theoretically. Here we show that the thermodynamic theory of self-assembly…

Soft Condensed Matter · Physics 2021-03-04 Andrei A. Klishin , Michael P. Brenner

Multimodal structures in the sampling density (e.g. two competing phases) can be a serious problem for traditional Markov Chain Monte Carlo (MCMC), because correct sampling of the different structures can only be guaranteed for infinite…

Data Analysis, Statistics and Probability · Physics 2009-11-11 M. Daghofer , M. Konegger , H. G. Evertz , W. von der Linden

Addressable self-assembly is the formation of a target structure from a set of unique molecular or colloidal building-blocks, each of which occupies a defined location in the target. The requirement that each type of building-block appears…

Soft Condensed Matter · Physics 2019-12-03 Jim Madge , David Bourne , Mark A. Miller

In this note we prove NP-hardness of the following problem: Given a set of matrices, is there a convex combination of those that is a nonsingular M-matrix? Via known characterizations of M-matrices, our result establishes NP-hardness of…

Optimization and Control · Mathematics 2012-06-12 Nikos Vlassis

Despite the recent progress of automated program verification techniques, fully automated verification of programs manipulating recursive data structures remains a challenge. We introduce solvable tuple patterns (STPs) and conjunctive STPs…

Programming Languages · Computer Science 2026-05-27 Naoki Kobayashi , Ryosuke Sato , Ayumi Shinohara , Ryo Yoshinaka

This survey presents an overview of verification techniques for autonomous systems, with a focus on safety-critical autonomous cyber-physical systems (CPS) and subcomponents thereof. Autonomy in CPS is enabling by recent advances in…

We study the Borel-Moore homology of stacks of representations of preprojective algebras $\Pi_Q$, via the study of the DT theory of the undeformed 3-Calabi-Yau completion $\Pi_Q[x]$. Via a result on the supports of the BPS sheaves for…

Algebraic Geometry · Mathematics 2022-03-28 Ben Davison

The Pattern self-Assembly Tile set Synthesis (PATS) problem is to determine a set of coloured tiles that self-assemble to implement a given rectangular colour pattern. We give an exhaustive branch-and-bound algorithm to find tile sets of…

Data Structures and Algorithms · Computer Science 2015-03-13 Mika Göös , Pekka Orponen

We prove a representation stability result for the codimension-one cohomology of the level three congruence subgroup of $\mathbf{SL}_n(\mathbb{Z})$. This is a special case of a question of Church-Farb-Putman which we make more precise. Our…

Algebraic Topology · Mathematics 2020-05-14 Jeremy Miller , Rohit Nagpal , Peter Patzt

Working in Winfree's abstract tile assembly model, we show that a constant-size tile assembly system can be programmed through relative tile concentrations to build an n x n square with high probability, for any sufficiently large n. This…

Computational Complexity · Computer Science 2015-03-13 David Doty

The spectra of signed matrices have played a fundamental role in social sciences, graph theory, and control theory. In this work, we investigate the computational problems of identifying symmetric signings of matrices with natural spectral…

Discrete Mathematics · Computer Science 2017-07-25 Charles Carlson , Karthekeyan Chandrasekaran , Hsien-Chih Chang , Alexandra Kolla

P-time event graphs are discrete event systems able to model cyclic production systems where tasks need to be performed within given time windows. Consistency is the property of admitting an infinite execution of such tasks that does not…

Logic in Computer Science · Computer Science 2026-02-10 Davide Zorzenon , Jörg Raisch

Motivated by the theory of proof complexity generators we consider the following $\Sigma^p_2$ search problem $\mbox{DD}_P$ determined by a propositional proof system $P$: given a $P$-proof $\pi$ of a disjunction $\bigvee_i {\alpha}_i$, no…

Computational Complexity · Computer Science 2026-05-13 Jan Krajicek

It is suggested a testing puzzle able to reveal the self-asserting property of the homogeneous vector potential field. As pieces of the puzzle are taken three reliable entities : (i) influence of a potential vector on the de Broglie…

Quantum Physics · Physics 2014-04-18 Spiridon Dumitru

The algebraic dichotomy conjecture for Constraint Satisfaction Problems (CSPs) of reducts of (infinite) finitely bounded homogeneous structures states that such CSPs are polynomial-time tractable if the model-complete core of the template…

The product homomorphism problem (PHP) takes as input a finite collection of relational structures A1, ..., An and another relational structure B, all over the same schema, and asks whether there is a homomorphism from the direct product A1…

Discrete Mathematics · Computer Science 2012-12-17 Balder ten Cate , Víctor Dalmau

The field of algorithmic self-assembly is concerned with the design and analysis of self-assembly systems from a computational perspective, that is, from the perspective of mathematical problems whose study may give insight into the natural…

Neural and Evolutionary Computing · Computer Science 2011-03-14 Fabio R. J. Vieira , Valmir C. Barbosa

The constraint satisfaction problem (CSP) is concerned with homomorphisms between two structures. For CSPs with restricted left-hand side structures, the results of Dalmau, Kolaitis, and Vardi [CP'02], Grohe [FOCS'03/JACM'07], and Atserias,…

Computational Complexity · Computer Science 2022-02-02 Clement Carbonnel , Miguel Romero , Stanislav Zivny