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Traditional causal connectivity methods in task-based and resting-state functional magnetic resonance imaging (fMRI) face challenges in accurately capturing directed information flow due to their sensitivity to noise and inability to model…

Neurons and Cognition · Quantitative Biology 2025-04-03 Boseong Kim , Debashis Das Chakladar , Haejun Chung , Ikbeom Jang

Resting-state functional magnetic resonance imaging (rs-fMRI) is a noninvasive technique pivotal for understanding human neural mechanisms of intricate cognitive processes. Most rs-fMRI studies compute a single static functional…

Neurons and Cognition · Quantitative Biology 2025-02-25 Bishal Thapaliya , Robyn Miller , Jiayu Chen , Yu-Ping Wang , Esra Akbas , Ram Sapkota , Bhaskar Ray , Pranav Suresh , Santosh Ghimire , Vince Calhoun , Jingyu Liu

Brain functional connectivity (FC), the temporal synchrony between brain networks, is essential to understand the functional organization of the brain and to identify changes due to neurological disorders, development, treatment, and other…

Applications · Statistics 2025-06-18 Amanda Mejia , David Bolin , Daniel Spencer , Ani Eloyan

Many analyses of functional magnetic resonance imaging (fMRI) examine functional connectivity (FC), or the statistical dependencies among distant brain regions. These analyses are typically exploratory, guiding future confirmatory research.…

Applications · Statistics 2025-10-20 Kyle Stanley , Nicole Lazar , Matthew Reimherr

There has been increasing interests in learning resting-state brain functional connectivity of autism disorders using functional magnetic resonance imaging (fMRI) data. The data in a standard brain template consist of over 200,000 voxel…

Methodology · Statistics 2016-03-22 Jichun Xie , Jian Kang

The brain is an assembly of neuronal populations interconnected by structural pathways. Brain activity is expressed on and constrained by this substrate. Therefore, statistical dependencies between functional signals in directly connected…

Neurons and Cognition · Quantitative Biology 2019-09-11 Maria Giulia Preti , Dimitri Van De Ville

The study of functional brain connectivity (FC) is important for understanding the underlying mechanisms of many psychiatric disorders. Many recent analyses adopt graph convolutional networks, to study non-linear interactions between…

Neurons and Cognition · Quantitative Biology 2021-09-08 Simon Dahan , Logan Z. J. Williams , Daniel Rueckert , Emma C. Robinson

Brain networks have received considerable attention given the critical significance for understanding human brain organization, for investigating neurological disorders and for clinical diagnostic applications. Structural brain network…

Machine Learning · Computer Science 2019-11-12 Jiahao Liu , Guixiang Ma , Fei Jiang , Chun-Ta Lu , Philip S. Yu , Ann B. Ragin

Human brain structural networks contain sets of centrally embedded hub regions that enable efficient information communication. However, it remains largely unknown about categories of structural brain hubs and their microstructural,…

Neurons and Cognition · Quantitative Biology 2016-09-13 Xindi Wang , Qixiang Lin , Mingrui Xia , Yong He

Non-invasive measurements of the human brain using magnetic resonance imaging (MRI) have significantly improved our understanding the brain's network organization by enabling measurement of anatomical connections between brain regions…

Applications · Statistics 2025-12-10 Keshav Motwani , Ali Shojaie , Ariel Rokem , Eardi Lila

Measuring functional connectivity from fMRI is important in understanding processing in cortical networks. However, because brain's connection pattern is complex, currently used methods are prone to produce false connections. We introduce…

Neurons and Cognition · Quantitative Biology 2020-06-23 Tiger w. Lin , Giri P. Krishnan , Maxim Bazhenov , Terrence J. Sejnowski

A central question in neuroscience is how self-organizing dynamic interactions in the brain emerge on their relatively static structural backbone. Due to the complexity of spatial and temporal dependencies between different brain areas,…

Neurons and Cognition · Quantitative Biology 2020-10-15 Simon Wein , Wilhelm Malloni , Ana Maria Tomé , Sebastian M. Frank , Gina-Isabelle Henze , Stefan Wüst , Mark W. Greenlee , Elmar W. Lang

Empirical studies over the past two decades have supported the hypothesis that schizophrenia is characterized by altered connectivity patterns in functional brain networks. These alterations have been proposed as genetically-mediated…

Neurons and Cognition · Quantitative Biology 2013-06-28 Felix Siebenhuhner , Shennan A. Weiss , Richard Coppola , Daniel R. Weinberger , Danielle S. Bassett

Major depressive disorder (MDD) is a common neuropsychiatric condition whose accurate diagnosis from resting-state functional magnetic resonance imaging (rs-fMRI) remains difficult. Dynamic functional connectivity (DFC) captures…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Muhammad Asif Hasan , Yanming Zhu , Xuefei Yin , Alan Wee-Chung Liew

Estimating brain effective connectivity (EC) from functional magnetic resonance imaging (fMRI) data can aid in comprehending the neural mechanisms underlying human behavior and cognition, providing a foundation for disease diagnosis.…

Machine Learning · Computer Science 2025-03-17 Wen Xiong , Jinduo Liu , Junzhong Ji , Fenglong Ma

Predicting cognition from neuroimaging data in healthy individuals offers insights into the neural mechanisms underlying cognitive abilities, with potential applications in precision medicine and early detection of neurological and…

Machine Learning · Computer Science 2025-07-29 Jagruti Patel , Mikkel Schöttner , Thomas A. W. Bolton , Patric Hagmann

Healthy brain networks usually show highly efficient information communication and self-sustained oscillation abilities. However, how the brain network structure affects these dynamics after an injury (stroke) is not very clear. The…

Physics and Society · Physics 2025-06-12 Yingpeng Liu , Jiao Wu , Kesheng Xu , Muhua Zheng

We investigate the relationship of resting-state fMRI functional connectivity estimated over long periods of time with time-varying functional connectivity estimated over shorter time intervals. We show that using Pearson's correlation to…

Neurons and Cognition · Quantitative Biology 2016-09-08 Richard F. Betzel , Makoto Fukushima , Ye He , Xi-Nian Zuo , Olaf Sporns

We consider exploratory methods for the discovery of cortical functional connectivity. Typically, data for the i-th subject (i=1...NS) is represented as an NVxNT matrix Xi, corresponding to brain activity sampled at NT moments in time from…

Methodology · Statistics 2011-03-17 Roberto D. Pascual-Marqui , Rolando J. Biscay-Lirio

Resting-state functional magnetic resonance imaging (rs-fMRI) offers valuable insights into the human brain's functional organization and is a powerful tool for investigating the relationship between brain function and cognitive processes,…

Machine Learning · Computer Science 2025-02-10 Bishal Thapaliya , Esra Akbas , Ram Sapkota , Bhaskar Ray , Vince Calhoun , Jingyu Liu