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This paper investigates the incompressible limit of a system modelling the growth of two cells population. The model describes the dynamics of cell densities, driven by pressure exclusion and cell proliferation. It has been shown that…

Analysis of PDEs · Mathematics 2019-01-08 P. Degond , S. Hecht , N. Vauchelet

This paper proposes a model for the growth two interacting populations of cells that do not mix. The dynamics is driven by pressure and cohesion forces on the one hand and proliferation on the other hand. Following earlier works on the…

Cell Behavior · Quantitative Biology 2018-04-12 Alina Chertock , Pierre Degond , Sophie Hecht , Jean-Paul Vincent

In this paper we study a cross-diffusion system whose coefficient matrix is non-symmetric and degenerate. The system arises in the study of tissue growth with autophagy. The existence of a weak solution is established. We also investigate…

Analysis of PDEs · Mathematics 2021-06-22 Jian-Guo Liu , Xiangsheng Xu

We study the incompressible limit of the porous medium equation with a right hand side representing either a source or a sink term, and an injection boundary condition. This model can be seen as a simplified description of non-monotone…

Analysis of PDEs · Mathematics 2022-01-12 Nestor Guillen , Inwon Kim , Antoine Mellet

Both compressible and incompressible porous medium models are used in the literature to describe the mechanical properties of living tissues. These two classes of models can be related using a stiff pressure law. In the incompressible…

Analysis of PDEs · Mathematics 2020-06-25 Noemi David , Benoît Perthame

We study a porous medium equation that models tissue growth in a heterogeneous environment. We show that, in the incompressible limit, solutions converge to those of a weak form of a Hele-Shaw type free boundary problem. To obtain enough…

Analysis of PDEs · Mathematics 2025-12-11 Anthony Sulak , Olga Turanova

Models of tumor growth, now commonly used, present several levels of complexity, both in terms of the biomedical ingredients and the mathematical description. The simplest ones contain competition for space using purely fluid mechanical…

Analysis of PDEs · Mathematics 2015-06-12 Benoît Perthame , Fernando Quirós , Juan Luis Vázquez

Various models of tumor growth are available in the litterature. A first class describes the evolution of the cell number density when considered as a continuous visco-elastic material with growth. A second class, describes the tumor as a…

Analysis of PDEs · Mathematics 2016-02-17 Benoit Perthame , Nicolas Vauchelet

We formulate a Hele-Shaw type free boundary problem for a tumor growing under the combined effects of pressure forces, cell multiplication and active motion, the latter being the novelty of the present paper. This new ingredient is…

Analysis of PDEs · Mathematics 2014-01-14 Benoît Perthame , Fernando Quirós , Min Tang , Nicolas Vauchelet

In this paper, we consider an age-structured mechanical model for tumor growth. This model takes into account the life-cycle of tumor cells by including an age variable. The underlying process for tumor growth is the same as classical tumor…

Analysis of PDEs · Mathematics 2026-03-05 Maeve Wildes

In this paper we study singular limits of congestion-averse growth models, connecting different models describing the effect of congestion. These models arise in particular in the context of tissue growth. The main ingredient of our…

Analysis of PDEs · Mathematics 2025-03-25 Noemi David , Matt Jacobs , Inwon Kim

We consider a (degenerate) cross-diffusion model of tumor growth structured by phenotypic trait. We prove the existence of weak solutions and the incompressible limit as the pressure becomes stiff extending methods recently introduced in…

Analysis of PDEs · Mathematics 2023-04-04 Noemi David

We consider weak solutions to a problem modeling tumor growth. Under certain conditions on the initial data, solutions can be obtained by passing to the stiff (incompressible) limit in a porous medium type problem with a Lotka-Volterra…

Analysis of PDEs · Mathematics 2015-12-23 Antoine Mellet , Benoît Perthame , Fernando Quiros

In this work we study a tissue growth model with applications to tumour growth. The model is based on that of Perthame, Quir\'os, and V\'azquez proposed in 2014 but incorporates the advective effects caused, for instance, by the presence of…

Analysis of PDEs · Mathematics 2021-03-04 Noemi David , Markus Schmidtchen

We consider a model of congestion dynamics with chemotaxis, where the density of cells follows the chemical signal it generates, while observing an incompressibility constraint. We show that when the chemical diffuses slowly and attracts…

Analysis of PDEs · Mathematics 2022-04-27 Inwon Kim , Antoine Mellet , Yijing Wu

In this paper we study the "stiff pressure limit" of the porous medium equation, where the initial density is a bounded, integrable function with a sufficient decay at infinity. Our particular model, introduced by Perthame-Quiros-Vazquez,…

Analysis of PDEs · Mathematics 2015-09-22 Inwon Kim , Norbert Pozar

We investigate the general Porous Medium Equations with drift and source terms that model tumor growth. Incompressible limit of such models has been well-studied in the literature, where convergence of the density and pressure variables are…

Analysis of PDEs · Mathematics 2024-03-12 Jiajun Tong , Yuming Paul Zhang

We study the "stiff pressure limit" of a nonlinear drift-diffusion equation, where the density is constrained to stay below the maximal value one. The challenge lies in the presence of a drift and the consequent lack of monotonicity in…

Analysis of PDEs · Mathematics 2017-08-22 Inwon Kim , Norbert Požár , Brent Woodhouse

We investigate the large time behavior of an agent based model describing tumor growth. The microscopic model combines short-range repulsion and cell division. As the number of cells increases exponentially in time, the microscopic model is…

Soft Condensed Matter · Physics 2017-01-04 Sebastien Motsch , Diane Peurichard

We consider a model of congestion dynamics with chemotaxis: The density of cells follows a chemical signal it generates, while subject to an incompressibility constraint. The incompressibility constraint results in the formation of patches,…

Analysis of PDEs · Mathematics 2023-01-18 Inwon Kim , Antoine Mellet , Yijing Wu
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