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We consider the problem of learning a conditional Gaussian graphical model in the presence of latent variables. Building on recent advances in this field, we suggest a method that decomposes the parameters of a conditional Markov random…

Methodology · Statistics 2017-03-07 Benjamin Frot , Luke Jostins , Gil McVean

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based auto encoders have shown great potential in detecting anomalies in medical images. However, state-of-the-art…

Machine Learning · Computer Science 2018-12-17 David Zimmerer , Simon A. A. Kohl , Jens Petersen , Fabian Isensee , Klaus H. Maier-Hein

Recently there has been an increased interest in unsupervised learning of disentangled representations using the Variational Autoencoder (VAE) framework. Most of the existing work has focused largely on modifying the variational cost…

Machine Learning · Statistics 2019-09-12 Jan Stühmer , Richard E. Turner , Sebastian Nowozin

Variational autoencoders (VAEs) typically encode images into a compact latent space, reducing computational cost but introducing an optimization dilemma: a higher-dimensional latent space improves reconstruction fidelity but often hampers…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Xunzhi Xiang , Xingye Tian , Guiyu Zhang , Yabo Chen , Shaofeng Zhang , Xuebo Wang , Xin Tao , Qi Fan

Longitudinal datasets measured repeatedly over time from individual subjects, arise in many biomedical, psychological, social, and other studies. A common approach to analyse high-dimensional data that contains missing values is to learn a…

Machine Learning · Statistics 2021-04-21 Siddharth Ramchandran , Gleb Tikhonov , Kalle Kujanpää , Miika Koskinen , Harri Lähdesmäki

Variational Autoencoders (VAEs) are a popular generative model, but one in which conditional inference can be challenging. If the decomposition into query and evidence variables is fixed, conditional VAEs provide an attractive solution. To…

Machine Learning · Statistics 2018-10-05 Ga Wu , Justin Domke , Scott Sanner

Latent variable models such as the Variational Auto-Encoder (VAE) have become a go-to tool for analyzing biological data, especially in the field of single-cell genomics. One remaining challenge is the interpretability of latent variables…

Genomics · Quantitative Biology 2023-02-20 Romain Lopez , Nataša Tagasovska , Stephen Ra , Kyunghyn Cho , Jonathan K. Pritchard , Aviv Regev

Deep latent variable models (LVM) such as variational auto-encoder (VAE) have recently played an important role in text generation. One key factor is the exploitation of smooth latent structures to guide the generation. However, the…

Machine Learning · Computer Science 2019-12-02 Le Fang , Chunyuan Li , Jianfeng Gao , Wen Dong , Changyou Chen

Optimization in the latent space of variational autoencoders is a promising approach to generate high-dimensional discrete objects that maximize an expensive black-box property (e.g., drug-likeness in molecular generation, function…

Machine Learning · Computer Science 2021-07-02 Pascal Notin , José Miguel Hernández-Lobato , Yarin Gal

Variational autoencoders were proven successful in domains such as computer vision and speech processing. Their adoption for modeling user preferences is still unexplored, although recently it is starting to gain attention in the current…

Machine Learning · Computer Science 2018-11-27 Noveen Sachdeva , Giuseppe Manco , Ettore Ritacco , Vikram Pudi

Variational Autoencoders (VAEs) provide a theoretically-backed and popular framework for deep generative models. However, learning a VAE from data poses still unanswered theoretical questions and considerable practical challenges. In this…

Machine Learning · Computer Science 2020-06-01 Partha Ghosh , Mehdi S. M. Sajjadi , Antonio Vergari , Michael Black , Bernhard Schölkopf

When labeled training data is scarce, a promising data augmentation approach is to generate visual features of unknown classes using their attributes. To learn the class conditional distribution of CNN features, these models rely on pairs…

Computer Vision and Pattern Recognition · Computer Science 2019-03-26 Yongqin Xian , Saurabh Sharma , Bernt Schiele , Zeynep Akata

Although variational autoencoders (VAEs) represent a widely influential deep generative model, many aspects of the underlying energy function remain poorly understood. In particular, it is commonly believed that Gaussian encoder/decoder…

Machine Learning · Computer Science 2019-10-31 Bin Dai , David Wipf

Large occlusions result in a significant decline in image classification accuracy. During inference, diverse types of unseen occlusions introduce out-of-distribution data to the classification model, leading to accuracy dropping as low as…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Ketan Kotwal , Tanay Deshmukh , Preeti Gopal

Variational Autoencoders (VAE) are popular generative models used to sample from complex data distributions. Despite their empirical success in various machine learning tasks, significant gaps remain in understanding their theoretical…

Machine Learning · Statistics 2025-12-23 Sobihan Surendran , Antoine Godichon-Baggioni , Sylvain Le Corff

Hierarchical Variational Autoencoders (VAEs) are among the most popular likelihood-based generative models. There is a consensus that the top-down hierarchical VAEs allow effective learning of deep latent structures and avoid problems like…

Machine Learning · Computer Science 2023-09-29 Anna Kuzina , Jakub M. Tomczak

Variational Autoencoders (VAE) are widely used for dimensionality reduction of large-scale tabular and image datasets, under the assumption of independence between data observations. In practice, however, datasets are often correlated, with…

Machine Learning · Statistics 2024-12-25 Giora Simchoni , Saharon Rosset

Masked autoencoder (MAE), a simple and effective self-supervised learning framework based on the reconstruction of masked image regions, has recently achieved prominent success in a variety of vision tasks. Despite the emergence of…

Machine Learning · Computer Science 2023-06-09 Lingjing Kong , Martin Q. Ma , Guangyi Chen , Eric P. Xing , Yuejie Chi , Louis-Philippe Morency , Kun Zhang

Variational Autoencoders (VAEs) typically rely on a probabilistic decoder with a predefined likelihood, most commonly an isotropic Gaussian, to model the data conditional on latent variables. While convenient for optimization, this choice…

Machine Learning · Statistics 2025-04-29 Chen Xu , Qiang Wang , Lijun Sun

The integrative analysis of histopathological images and genomic data has received increasing attention for survival prediction of human cancers. However, the existing studies always hold the assumption that full modalities are available.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Junjie Zhou , Jiao Tang , Yingli Zuo , Peng Wan , Daoqiang Zhang , Wei Shao