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In this paper we are interested in testing whether there are any signals hidden in high dimensional noise data. Therefore we study the family of goodness-of-fit tests based on $\Phi$-divergences including the test of Berk and Jones as well…
A unified family of goodness-of-fit tests based on $\phi$-divergences is introduced and studied. The new family of test statistics $S_n(s)$ includes both the supremum version of the Anderson--Darling statistic and the test statistic of Berk…
Goodness-of-fit (GoF) tests are a fundamental component of statistical practice, essential for checking model assumptions and testing scientific hypotheses. Despite their widespread use, popular GoF tests exhibit surprisingly low…
In genetic association studies, rare variants with extremely small allele frequency play a crucial role in complex traits, and the set-based testing methods that jointly assess the effects of groups of single nucleotide polymorphisms (SNPs)…
Continuous goodness-of-fit testing is a classical problem in statistics. Despite having low power for detecting deviations at the tail of a distribution, the most popular test is based on the Kolmogorov-Smirnov statistic. While similar…
Large-scale multiple testing problems require the simultaneous assessment of many p-values. This paper compares several methods to assess the evidence in multiple binomial counts of p-values: the maximum of the binomial counts after…
Studying the effects of groups of Single Nucleotide Polymorphisms (SNPs), as in a gene, genetic pathway, or network, can provide novel insight into complex diseases, above that which can be gleaned from studying SNPs individually. Common…
Meta-analysis techniques have been widely developed and applied in genomic applications, especially for combining multiple transcriptomic studies. In this paper we propose an order statistic of $p$-values ($r$th ordered $p$-value, rOP)…
This paper concerns the problem of applying the generalized goodness-of-fit (gGOF) type tests for analyzing correlated data. The gGOF family broadly covers the maximum-based testing procedures by ordered input $p$-values, such as the false…
We propose a method for comparing survival data based on the higher criticism of p-values obtained from multiple exact hypergeometric tests. The method accommodates non-informative right-censorship and is sensitive to hazard differences in…
The objective of goodness-of-fit testing is to assess whether a dataset of observations is likely to have been drawn from a candidate probability distribution. This paper presents a rank-based family of goodness-of-fit tests that is…
We study the problem of testing discrete distributions with a focus on the high probability regime. Specifically, given samples from one or more discrete distributions, a property $\mathcal{P}$, and parameters $0< \epsilon, \delta <1$, we…
Often when we deal with `Big Data', the true effects we are interested in are Rare and Weak (RW). Researchers measure a large number of features, hoping to find perhaps only a small fraction of them to be relevant to the research in…
In genetic studies of complex diseases, the underlying mode of inheritance is often not known. Thus, the most powerful test or other optimal procedure for one model, e.g. recessive, may be quite inefficient if another model, e.g. dominant,…
A large class of goodness-of-fit test statistics based on sup-functionals of weighted empirical processes is proposed and studied. The weight functions employed are Erd\H{o}s-Feller-Kolmogorov-Petrovski upper-class functions of a Brownian…
Instead of defining goodness of fit (GOF) tests in terms of their test statistics, we present an alternative method by introducing the concept of local levels, which indicate high or low local sensitivity of a test. Local levels can act as…
Data-driven most powerful tests are statistical hypothesis decision-making tools that deliver the greatest power against a fixed null hypothesis among all corresponding data-based tests of a given size. When the underlying data…
The issue of combining individual $p$-values to aggregate multiple small effects is prevalent in many scientific investigations and is a long-standing statistical topic. Many classical methods are designed for combining independent and…
In modern high-throughput data analysis, researchers perform a large number of statistical tests, expecting to find perhaps a small fraction of significant effects against a predominantly null background. Higher Criticism (HC) was…
In this paper, we use and further develop upon a recently proposed multivariate, distribution-free Goodness-of-Fit (GoF) test based on the theory of Optimal Transport (OT) called the Rank Energy (RE) [1], for non-parametric and unsupervised…