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Single molecule localization microscopy (SMLM) techniques enable imaging biological samples well beyond the diffraction limit of light, but they vary significantly in their spatial and temporal resolutions. High-order statistical analysis…

Biological Physics · Physics 2016-03-15 Shachar Schidorsky , Xiyu Yi , Yair Razvag , Yonatan Golan , Shimon Weiss , Eilon Sherman

Confocal laser scanning microscopy (CLSM) stands out as one of the most widely used microscopy techniques, thanks to its three-dimensional imaging capability and its sub-diffraction spatial resolution, achieved through the closure of a…

We provide a quantitative analysis of super-resolution imaging techniques which exploit temporal fluctuations of luminosity of the sources in order to beat the Rayleigh limit. We define an operationally justified resolution gain figure of…

Quantum Physics · Physics 2021-06-08 Stanislaw Kurdzialek , Rafal Demkowicz-Dobrzanski

Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Paloma Casteleiro Costa , Parnian Ghapandar Kashani , Xuhui Liu , Alexander Chen , Ary Portes , Julien Bec , Laura Marcu , Aydogan Ozcan

We report resolution enhancement in scanning electron microscopy (SEM) images using a generative adversarial network. We demonstrate the veracity of this deep learning-based super-resolution technique by inferring unresolved features in…

Computer Vision and Pattern Recognition · Computer Science 2019-08-21 Kevin de Haan , Zachary S. Ballard , Yair Rivenson , Yichen Wu , Aydogan Ozcan

The localisation of fluorophores is an important aspect of the determination of the biological function of cellular systems. Quantum correlation microscopy (QCM) is a promising technique for providing diffraction unlimited emitter…

Quantum Physics · Physics 2023-10-05 Shuo Li , Wenchao Li , Qiang Sun , Bill Moran , Timothy C. Brown , Brant C. Gibson , Andrew D. Greentree

Structured illumination microscopy (SIM) can achieve a $2\times$ resolution enhancement beyond the classical diffraction limit by employing illumination translations with respect to the object. This method has also been successfully…

Traditional image quality assessment metrics like Mean Squared Error and Structural Similarity Index often fail to reflect perceptual quality under complex distortions. We propose the Hybrid Image Resolution Quality Metric (HIRQM),…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 Vineesh Kumar Reddy Mondem

In traditional optical imaging systems, the spatial resolution is limited by the physics of diffraction, which acts as a low-pass filter. The information on sub-wavelength features is carried by evanescent waves, never reaching the camera,…

Optics · Physics 2018-12-13 Oren Solomon , Yonina C. Eldar , Maor Mutzafi , Mordechai Segev

Resolving signals with closely spaced frequencies is central to applications in communications, spectroscopy and sensing. Recent results have shown that quantum sensing protocols can exhibit superresolution, the ability to discriminate…

Quantum Physics · Physics 2026-02-13 Joseph T. Iosue , Paraj Titum , Taohan Lin , Clare Lau , Leigh M. Norris

Quantum imaging with undetected photons (QIUP) is a unique method of image acquisition where the photons illuminating the object are not detected. This method relies on quantum interference and spatial correlations between the twin photons…

Quantum Physics · Physics 2024-07-29 Balakrishnan Viswanathan , Gabriela Barreto Lemos , Mayukh Lahiri

Scanning superconducting quantum interference device microscopy (SSM) is a scanning probe technique that images local magnetic flux, which allows for mapping of magnetic fields with high field and spatial accuracy. Many studies involving…

Instrumentation and Detectors · Physics 2018-01-17 P. Reith , X. Renshaw Wang , H. Hilgenkamp

We proposed a new approach, which is inspired by the method of super-resolution (SR) structured illumination microscopy (SIM) for overcoming the resolution limit in microscopy due to diffraction of light, for increasing the resolution of…

Medical Physics · Physics 2026-02-04 Youdong Lang , Qingguo Xie , Chien-Min Kao

We report the experimental realization of a quantum silicon carbide microscope (QSiCM) and demonstrate its functionality by imaging magnetic fields generated by electrical currents. We employ a dual-frequency sensing protocol to enhance the…

Quantum Physics · Physics 2025-09-19 A. Suhana , T. A. U. Svetikova , C. Schneider , M. Helm , A. N. Anisimov , G. V. Astakhov

Second order intensity correlations of speckle illumination are extensively used in imaging applications that require going beyond the Rayleigh limit. The theoretical analysis shows that significantly improved imaging can be extracted from…

Optics · Physics 2019-12-03 Fu Li , Charles Altuzarra , Tian Li , M. O. Scully , G. S. Agarwal

Single-image super-resolution (SISR) is a canonical problem with diverse applications. Leading methods like SRGAN produce images that contain various artifacts, such as high-frequency noise, hallucinated colours and shape distortions, which…

Machine Learning · Computer Science 2018-10-03 Ke Li , Shichong Peng , Jitendra Malik

Breaking the diffraction limit in microscopy by utilizing quantum properties of light has been the goal of intense research in the recent years. We propose a quantum superresolution technique based on non-classical emission statistics of…

Optics · Physics 2013-05-30 Osip Schwartz , Dan Oron

Super-resolution effects in optical and fluorescence biological systems are analyzed and their relations with uncertainty relations are discussed. Super-resolutions obtained in the optical systems, including especially NSOM, SIM and…

Optics · Physics 2015-06-12 Yacob Ben-Aryeh

Improving resolution and sensitivity will widen possible medical applications of magnetic particle imaging. Pulsed excitation promises such benefits, at the cost of more complex hardware solutions and restrictions on drive field amplitude…

The image Super-Resolution (SR) technique has greatly improved the visual quality of images by enhancing their resolutions. It also calls for an efficient SR Image Quality Assessment (SR-IQA) to evaluate those algorithms or their generated…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Keke Zhang , Tiesong Zhao , Weiling Chen , Yuzhen Niu , Jinsong Hu