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The Escherichia coli chemotaxis signaling pathway has served as a model system for studying the adaptive sensing of environmental signals by large protein complexes. The chemoreceptors control the kinase activity of CheA in response to the…

Biological Physics · Physics 2023-10-16 David Hathcock , Qiwei Yu , Bernardo A. Mello , Divya N. Amin , Gerald L. Hazelbauer , Yuhai Tu

We propose a unified learning framework for identifying the profile function in discrete Keller-Segel equations, which are widely used mathematical models for understanding chemotaxis. Training data are obtained via either a rigorously…

Numerical Analysis · Mathematics 2025-10-28 Chi-An Chen , Chun Liu , Ming Zhong

Chemotaxis is the response of a particle to a gradient in the chemical composition of the environment. While it was originally observed for biological organisms, it is of great interest in the context of synthetic active particles such as…

Soft Condensed Matter · Physics 2017-05-02 Laurens Deprez , Pierre de Buyl

Chemotaxis is typically modeled in the context of cellular motion towards a static, exogenous source of chemoattractant. Here, we propose a time-dependent mechanism of chemotaxis in which a self-propelled particle ({\it e.g.}, a cell)…

Cell Behavior · Quantitative Biology 2026-05-12 Sarah A. Nowak , Buddhapriya Chakrabarti , Tom Chou , Ajay Gopinathan

Cell-to-cell variations in protein abundance in clonal cell populations are ubiquitous in living systems. Since protein composition determines responses in individual cells, it stands to reason that the variations themselves are subject to…

Cell Behavior · Quantitative Biology 2013-11-01 Sayak Mukherjee , Sang-Cheol Seok , Veronica J. Vieland , Jayajit Das

The hydrodynamic limit for a kinetic model of chemotaxis is investigated. The limit equation is a non local conservation law, for which finite time blow-up occurs, giving rise to measure-valued solutions and discontinuous velocities. An…

Analysis of PDEs · Mathematics 2011-12-05 François James , Nicolas Vauchelet

For given total mass $m>0$ we show unique solvability of the stationary chemotaxis-consumption model \[ \begin{cases} 0= \Delta u - \chi \nabla \cdot (\frac{u}{v} \nabla v) \\ 0= \Delta v - uv \\ \int_\Omega u = m \end{cases} \] under…

Analysis of PDEs · Mathematics 2024-06-28 Jaewook Ahn , Johannes Lankeit

The Patlak-Keller-Segel equation is a canonical model of chemotaxis to describe self-organized aggregation of organisms interacting with chemical signals. We investigate a variant of this model, assuming that the organisms exert effective…

Statistical Mechanics · Physics 2017-10-30 Seung Ki Baek , Beom Jun Kim

This paper is devoted to constructing approximate solutions for the classical Keller--Segel model governing \emph{chemotaxis}. It consists of a system of nonlinear parabolic equations, where the unknowns are the average density of cells (or…

Numerical Analysis · Mathematics 2024-02-13 Juan Vicente Gutiérrez-Santacreu , José Rafael Rodríguez-Galván

We introduce mesoscopic and macroscopic model equations of chemotaxis with anomalous subdiffusion for modelling chemically directed transport of biological organisms in changing chemical environments with diffusion hindered by traps or…

Dynamical Systems · Mathematics 2012-12-03 T. A. M. Langlands , B. I. Henry

Flagellated bacteria, such as Escherichia coli, perform directed motion in gradients of concentration of attractants and repellents in a process called chemotaxis. The E. coli chemotaxis signaling pathway is a model for signal transduction,…

Biological Physics · Physics 2015-03-11 Anne-Florence Bitbol , Ned S. Wingreen

The paper is concerned with the following chemotaxis system with nonlinear motility functions \begin{equation}\label{0-1}\tag{$\ast$} \begin{cases} u_t=\nabla \cdot (\gamma(v)\nabla u- u\chi(v)\nabla v)+\mu u(1-u), &x\in \Omega, ~~t>0,…

Analysis of PDEs · Mathematics 2020-05-26 Hai-Yang Jin , Zhi-An Wang

This paper investigates the Keller-Segel model with quadratic cellular diffusion over a disk in $\mathbb R^2$ with a focus on the formation of its nontrivial patterns. We obtain explicit formulas of radially symmetric stationary solutions…

Analysis of PDEs · Mathematics 2019-11-07 Lin Chen , Fanze Kong , Qi Wang

The bacterium Escherichia coli (E. coli) moves in its natural environment in a series of straight runs, interrupted by tumbles which cause change of direction. It performs chemotaxis towards chemo-attractants by extending the duration of…

Quantitative Methods · Quantitative Biology 2010-07-12 Melissa Reneaux , Manoj Gopalakrishnan

A pathway-based mean-field theory (PBMFT) was recently proposed for E. coli chemotaxis in [G. Si, T. Wu, Q. Quyang and Y. Tu, Phys. Rev. Lett., 109 (2012), 048101]. In this paper, we derived a new moment system of PBMFT by using the moment…

Cell Behavior · Quantitative Biology 2013-04-29 Guangwei Si , Min Tang , Xu Yang

We consider an inertial model of chemotactic aggregation generalizing the Keller-Segel model and we study the linear dynamical stability of an infinite and homogeneous distribution of cells (bacteria, amoebae, endothelial cells,...) when…

Biological Physics · Physics 2009-11-13 Pierre-Henri Chavanis

In the present review we focus on the chemotaxis-consumption model $\partial_t u - \Delta u = - \nabla \cdot (u \nabla v)$ and $\partial_t v - \Delta v = - u^s v$ in $(0,T) \times \Omega$, for any fixed $s \geq 1$, endowed with isolated…

Analysis of PDEs · Mathematics 2024-02-12 André Luiz Corrêa Vianna Filho , Francisco Guillén-González

A chemotaxis-diffusion-convection coupling system for describing a form of buoyant convection in which the fluid develops convection cells and plume patterns will be investigated numerically in this study. Based on the two-dimensional…

Fluid Dynamics · Physics 2015-02-19 Yannick Deleuze , Chen-Yu Chiang , Marc Thiriet , Tony W. H. Sheu

We introduce a generic, purely mechanical model for environment sensitive motion of mammalian cells that is applicable to chemotaxis, haptotaxis, and durotaxis as modes of motility. It is able to theoretically explain all relevant…

Cell Behavior · Quantitative Biology 2016-05-09 Patrick Bitter , Kristof Leon Beck , Peter Lenz

Unboundedness of solutions is shown to occur in a one-dimensional quasilinear parabolicparabolic chemotaxis system for any initial mass. Our result is also independent of the relation between the speeds of the diffusion of cells and…

Analysis of PDEs · Mathematics 2012-12-04 Tomasz Cieślak