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The accurate diagnosis on pathological subtypes for lung cancer is of significant importance for the follow-up treatments and prognosis managements. In this paper, we propose self-generating hybrid feature network (SGHF-Net) for accurately…
Gene and protein networks are very important to model complex large-scale systems in molecular biology. Inferring or reverseengineering such networks can be defined as the process of identifying gene/protein interactions from experimental…
In cancer genomics, it is of great importance to distinguish driver mutations, which contribute to cancer progression, from causally neutral passenger mutations. We propose a random-effect regression approach to estimate the effects of…
We propose a constraint-based algorithm, which automatically determines causal relevance thresholds, to infer causal networks from data. We call these topological thresholds. We present two methods for determining the threshold: the first…
Despite the span in estimating pain from facial expressions, limited works have focused on estimating the sequence-level pain, which is reported by patients and used commonly in clinics. In this paper, we introduce a novel Statistical…
Background. Human aging is linked to many prevalent diseases. The aging process is highly influenced by genetic factors. Hence, it is important to identify human aging-related genes. We focus on supervised prediction of such genes. Gene…
Semi-supervised learning is a challenging problem which aims to construct a model by learning from a limited number of labeled examples. Numerous methods have been proposed to tackle this problem, with most focusing on utilizing the…
Node classification and graph classification are two graph learning problems that predict the class label of a node and the class label of a graph respectively. A node of a graph usually represents a real-world entity, e.g., a user in a…
Pancreatic ductal adenocarcinoma (PDAC) presents a critical global health challenge, and early detection is crucial for improving the 5-year survival rate. Recent medical imaging and computational algorithm advances offer potential…
Link prediction plays an important role in network analysis and applications. Recently, approaches for link prediction have evolved from traditional similarity-based algorithms into embedding-based algorithms. However, most existing…
Achieving precise medical image segmentation is vital for effective treatment planning and accurate disease diagnosis. Traditional fully-supervised deep learning methods, though highly precise, are heavily reliant on large volumes of…
Understanding the evolutionary patterns of real-world evolving complex systems such as human interactions, transport networks, biological interactions, and computer networks has important implications in our daily lives. Predicting future…
Prediction of node and graph labels are prominent network science tasks. Data analyzed in these tasks are sometimes related: entities represented by nodes in a higher-level (higher-scale) network can themselves be modeled as networks at a…
Although the currently popular deep learning networks achieve unprecedented performance on some tasks, the human brain still has a monopoly on general intelligence. Motivated by this and biological implausibility of deep learning networks,…
The structural analysis of shape boundaries leads to the characterization of objects as well as to the understanding of shape properties. The literature on graphs and networks have contributed to the structural characterization of shapes…
The accurate classification of benign and malignant pulmonary nodules in CT scans is critical for early lung cancer screening, yet remains challenging due to the multi-scale and heterogeneous nature of pulmonary nodules. While deep learning…
Quantifying the similarity between two networks is critical in many applications. A number of algorithms have been proposed to compute graph similarity, mainly based on the properties of nodes and edges. Interestingly, most of these…
In increasingly many settings, data sets consist of multiple samples from a population of networks, with vertices aligned across these networks. For example, brain connectivity networks in neuroscience consist of measures of interaction…
This paper addresses patient heterogeneity associated with prediction problems in biomedical applications. We propose a systematic hypothesis testing approach to determine the existence of patient subgroup structure and the number of…
Systematic relations between multiple objects that occur in various fields can be represented as networks. Real-world networks typically exhibit complex topologies whose structural properties are key factors in characterizing and further…