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Alzheimer's disease (AD) is the most common age-related dementia. Mild cognitive impairment (MCI) is the early stage of cognitive decline before AD. It is crucial to predict the MCI-to-AD conversion for precise management, which remains…

Image and Video Processing · Electrical Eng. & Systems 2022-03-10 Yiran Wei , Stephen J. Price , Carola-Bibiane Schönlieb , Chao Li

Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot…

Machine Learning · Computer Science 2019-03-25 Jack Albright

The expanding usage of complex machine learning methods like deep learning has led to an explosion in human activity recognition, particularly applied to health. In particular, as part of a larger body sensor network system, face and…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Salman Seyedi , Zifan Jiang , Allan Levey , Gari D. Clifford

The preclinical stage of many neurodegenerative diseases can span decades before symptoms become apparent. Understanding the sequence of preclinical biomarker changes provides a critical opportunity for early diagnosis and effective…

Methodology · Statistics 2024-06-11 Yizhen Xu , Scott Zeger , Zheyu Wang

Previous research shows that eye-tracking data contains information about the lexical and syntactic properties of text, which can be used to improve natural language processing models. In this work, we leverage eye movement features from…

Computation and Language · Computer Science 2019-03-29 Nora Hollenstein , Ce Zhang

Alzheimer's Disease and normal aging are both characterized by brain atrophy. The question of whether AD-related brain atrophy represents accelerated aging or a neurodegeneration process distinct from that in normal aging remains…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Jingru Fu , Daniel Ferreira , Örjan Smedby , Rodrigo Moreno

Timely and accurate diagnosis of neurodegenerative disorders, such as Alzheimer's disease, is central to disease management. Existing deep learning models require large-scale annotated datasets and often function as "black boxes".…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Duy-Cat Can , Quang-Huy Tang , Huong Ha , Binh T. Nguyen , Oliver Y. Chén

Using picture description speech for dementia detection has been studied for 30 years. Despite the long history, previous models focus on identifying the differences in speech patterns between healthy subjects and patients with dementia but…

Computation and Language · Computer Science 2023-08-17 Youxiang Zhu , Nana Lin , Xiaohui Liang , John A. Batsis , Robert M. Roth , Brian MacWhinney

Our research focuses on analysing human activities according to a known behaviorist scenario, in case of noisy and high dimensional collected data. The data come from the monitoring of patients with dementia diseases by wearable cameras. We…

Alzheimer's disease (AD) is an irreversible neurode generative disease of the brain.The disease may causes memory loss, difficulty communicating and disorientation. For the diagnosis of Alzheimer's disease, a series of scales are often…

Image and Video Processing · Electrical Eng. & Systems 2022-01-13 Yelu Gao , Huang Huang , Lian Zhang

The prevalence of suicide has been on the rise since the 20th century, causing severe emotional damage to individuals, families, and communities alike. Despite the severity of this suicide epidemic, there is so far no reliable and…

Signal Processing · Electrical Eng. & Systems 2022-06-16 Siyu Liu , Catherine Lu , Sharifa Alghowinem , Lea Gotoh , Cynthia Breazeal , Hae Won Park

Most of medical developments require the ability to identify samples that are anomalous with respect to a target group or control group, in the sense they could belong to a new, previously unseen class or are not class data. In this case…

Machine learning approaches for Alzheimer's disease (AD) diagnosis face a fundamental challenges. Clinical assessments are expensive and invasive, leaving ground truth labels available for only a fraction of neuroimaging datasets. We…

Machine Learning · Computer Science 2026-03-23 Alireza Moayedikia , Sara Fin

In the past decade, there has been a surge in research examining the use of voice and speech analysis as a means of detecting neurodegenerative diseases such as Alzheimer's. Many studies have shown that certain acoustic features can be used…

Audio and Speech Processing · Electrical Eng. & Systems 2023-07-20 Vrindha M. K. , Geethu V. , Anurenjan P. R. , Deepak S. , Sreeni K. G.

Facial expressions and actions differ among different individuals at varying degrees of intensity given responses to external stimuli, particularly among those that are neurodivergent. Such behaviors affect people in terms of overall…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Manuel Serna-Aguilera , Xuan Bac Nguyen , Han-Seok Seo , Khoa Luu

The current state-of-the-art deep neural networks (DNNs) for Alzheimer's Disease diagnosis use different biomarker combinations to classify patients, but do not allow extracting knowledge about the interactions of biomarkers. However, to…

Machine Learning · Computer Science 2021-09-28 Raphael Ronge , Kwangsik Nho , Christian Wachinger , Sebastian Pölsterl

Deep learning models for medical image analysis often act as black boxes, seldom aligning with clinical guidelines or explicitly linking decisions to supporting evidence. This is especially critical in Alzheimer's disease (AD), where…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Qiuhui Chen , Xuancheng Yao , Zhenglei Zhou , Xinyue Hu , Yi Hong

Alzheimer's disease (AD) is one of the most common public health issues the world is facing today. This disease has a high prevalence primarily in the elderly accompanying memory loss and cognitive decline. AD detection is a challenging…

Image and Video Processing · Electrical Eng. & Systems 2022-04-04 Zahraa Sh. Aaraji , Hawraa H. Abbas

Be it your favorite novel, a newswire article, a cooking recipe or an academic paper -- in many daily situations we read the same text more than once. In this work, we ask whether it is possible to automatically determine whether the reader…

Computation and Language · Computer Science 2026-02-10 Yoav Meiri , Omer Shubi , Cfir Avraham Hadar , Ariel Kreisberg Nitzav , Yevgeni Berzak

We use autoregressive hidden Markov models and a time-frequency approach to create meaningful quantitative descriptions of behavioral characteristics of cerebellar ataxias from wearable inertial sensor data gathered during movement.…

Neurons and Cognition · Quantitative Biology 2021-08-23 Karin C. Knudson , Anoopum S. Gupta