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Inspired by studies on the airports' network and the physical Internet, we propose a general model of weighted networks via an optimization principle. The topology of the optimal network turns out to be a spanning tree that minimizes a…

Physics and Society · Physics 2009-11-11 Marc Barthelemy , Alessandro Flammini

We consider a network of identical, first-order linear systems, and investigate how replacing a subset of the systems composing the network with higher-order ones, either taken to be generic or specifically designed, may affect its…

Optimization and Control · Mathematics 2025-04-25 Marco Peruzzo , Giacomo Baggio , Francesco Ticozzi

In order to understand the complex cognitive functions of the human brain, it is essential to study the structural connectome, i.e., the wiring of different brain regions to each other through axonal pathways. However, the high degree of…

Neurons and Cognition · Quantitative Biology 2021-01-25 Anand Pathak , Shakti N. Menon , Sitabhra Sinha

The irreducible complexity of natural phenomena has led Graph Neural Networks to be employed as a standard model to perform representation learning tasks on graph-structured data. While their capacity to capture local and global patterns is…

Machine Learning · Computer Science 2024-02-13 Lorenzo Giusti

The brain is immensely complex, with diverse components and dynamic interactions building upon one another to orchestrate a wide range of functions and behaviors. Understanding patterns of these complex interactions and how they are…

Neurons and Cognition · Quantitative Biology 2024-08-06 Suman Kulkarni , Dani S. Bassett

Control theory of dynamical systems offers a powerful framework for tackling challenges in deep neural networks and other machine learning architectures. We show that concepts such as simultaneous and ensemble controllability offer new…

Optimization and Control · Mathematics 2025-12-19 Enrique Zuazua

Recent advances at the intersection of control theory, neuroscience, and machine learning have revealed novel mechanisms by which dynamical systems perform computation. These advances encompass a wide range of conceptual, mathematical, and…

Machine Learning · Computer Science 2026-04-10 Arthur N. Montanari , Francesco Bullo , Dmitry Krotov , Adilson E. Motter

The ability to reroute and control flow is vital to the function of venation networks across a wide range of organisms. By modifying individual edges in these networks, either by adjusting edge conductances or creating and destroying edges,…

Soft Condensed Matter · Physics 2021-01-14 Jason W. Rocks , Andrea J. Liu , Eleni Katifori

Controlling complex networks is of paramount importance in science and engineering. Despite the recent development of structural-controllability theory, we continue to lack a framework to control undirected complex networks, especially…

Physics and Society · Physics 2013-10-23 Zhengzhong Yuan , Chen Zhao , Zengru Di , Wen-Xu Wang , Ying-Cheng Lai

Structural controllability has been proposed as an analytical framework for making predictions regarding the control of complex networks across myriad disciplines in the physical and life sciences (Liu et al., Nature:473(7346):167-173,…

Physics and Society · Physics 2015-05-28 Noah J. Cowan , Erick J. Chastain , Daril A. Vilhena , James S. Freudenberg , Carl T. Bergstrom

In this review, we give an introduction to the structural and functional properties of the biological networks. We focus on three major themes: topology of complex biological networks like the metabolic and protein-protein interaction…

Condensed Matter · Physics 2007-05-23 Indrani Bose

The Unfolded Protein Response is the cell mechanism for maintaining the balance of properly folded proteins in the endoplasmic reticulum , the specialized cellular compartment. Although it is largely studied from a biological point of view,…

Molecular Networks · Quantitative Biology 2023-04-05 Nicole Luchetti , Alessandro Loppini , Margherita Anna Grazia Matarrese , Letizia Chiodo , Simonetta Filippi

A recent publication provides the network graph for a neocortical microcircuit comprising 8 million connections between 31,000 neurons (H. Markram, et al., Reconstruction and simulation of neocortical microcircuitry, Cell, 163 (2015) no. 2,…

Neurons and Cognition · Quantitative Biology 2017-06-13 Pawe Dotko , Kathryn Hess , Ran Levi , Max Nolte , Michael Reimann , Martina Scolamiero , Katharine Turner , Eilif Muller , Henry Markram

Symmetries are an essential feature of complex networks as they regulate how the graph collective dynamics organizes into clustered states. We here show how to control network symmetries, and how to enforce patterned states of…

Physics and Society · Physics 2020-11-24 L. V. Gambuzza , M. Frasca , F. Sorrentino , L. M. Pecora , S. Boccaletti

The dynamical processes taking place on a network depend on its topology. Influencing the growth process of a network therefore has important implications on such dynamical processes. We formulate the problem of influencing the growth of a…

Social and Information Networks · Computer Science 2016-12-28 Dominik Thalmeier , Vicenç Gómez , Hilbert J. Kappen

Although two-dimensional periodic structures have functioned as the primary platform for exploring topological phenomena, recent advances have substantially expanded this research boundary to include more intricate, aperiodic structures:…

Mesoscale and Nanoscale Physics · Physics 2026-03-12 Sunkyu Yu , Xianji Piao , Namkyoo Park

Controlling complex networked systems to a desired state is a key research goal in contemporary science. Despite recent advances in studying the impact of network topology on controllability, a comprehensive understanding of the synergistic…

Optimization and Control · Mathematics 2014-08-04 Chen Zhao , Wen-Xu Wang , Yang-Yu Liu , Jean-Jacques Slotine

This chapter provides a comprehensive overview of controlling collective behavior in complex systems comprising large ensembles of interacting dynamical agents. Building upon traditional control theory's foundation in individual systems, we…

Systems and Control · Electrical Eng. & Systems 2025-07-01 Marco Coraggio , Davide Salzano , Mario di Bernardo

Recent work in the area of interdependent networks has focused on interactions between two systems of the same type. However, an important and ubiquitous class of systems are those involving monitoring and control, an example of…

Disordered Systems and Neural Networks · Physics 2013-09-27 Richard G. Morris , Marc Barthelemy

A social choice procedure is modeled as a repeated Nash game between the social agents, who are communicating with each other through a social communication network modeled by an undirected graph. The agents' criteria for this game are…

Systems and Control · Computer Science 2021-03-02 Athanasios-Rafail Lagos , George P. Papavassilopoulos