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We evolve network topology of an asymmetrically connected threshold network by a simple local rewiring rule: quiet nodes grow links, active nodes lose links. This leads to convergence of the average connectivity of the network towards the…

Disordered Systems and Neural Networks · Physics 2009-10-31 Stefan Bornholdt , Thimo Rohlf

A cell's behavior is a consequence of the complex interactions between its numerous constituents, such as DNA, RNA, proteins and small molecules. Cells use signaling pathways and regulatory mechanisms to coordinate multiple processes,…

Molecular Networks · Quantitative Biology 2007-09-12 Reka Albert

The human connectome represents a network map of the brain's wiring diagram and the pattern into which its connections are organized is thought to play an important role in cognitive function. The generative rules that shape the topology of…

Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behavior. Fundamental principles constraining these dynamic network processes have remained elusive. Here we use network control…

Neurons and Cognition · Quantitative Biology 2015-10-28 Shi Gu , Fabio Pasqualetti , Matthew Cieslak , Scott T. Grafton , Danielle S. Bassett

We derive an exact representation of the topological effect on the dynamics of sequence processing neural networks within signal-to-noise analysis. A new network structure parameter, loopiness coefficient, is introduced to quantitatively…

Disordered Systems and Neural Networks · Physics 2008-05-11 Pan Zhang , Yong Chen

Volumetric brain reconstructions provide an unprecedented opportunity to gain insights into the complex connectivity patterns of neurons in an increasing number of organisms. Here, we model and quantify the complexity of the resulting…

Neurons and Cognition · Quantitative Biology 2024-05-13 Anastasiya Salova , István A. Kovács

Cognitive control is a suite of processes that helps individuals pursue goals despite resistance or uncertainty about what to do. Although cognitive control has been extensively studied as a dynamic feedback loop of perception, valuation,…

The network structure (or topology) of a dynamical network is often unavailable or uncertain. Hence, we consider the problem of network reconstruction. Network reconstruction aims at inferring the topology of a dynamical network using…

Optimization and Control · Mathematics 2018-09-26 Henk J. van Waarde , Pietro Tesi , M. Kanat Camlibel

Networked systems are systems of interconnected components, in which the dynamics of each component are influenced by the behavior of neighboring components. Examples of networked systems include biological networks, critical…

Systems and Control · Computer Science 2016-06-01 Andrew Clark , Basel Alomair , Linda Bushnell , Radha Poovendran

The brain is an intricately structured organ responsible for the rich emergent dynamics that support the complex cognitive functions we enjoy as humans. With around $10^{11}$ neurons and $10^{15}$ synapses, understanding how the human brain…

Neurons and Cognition · Quantitative Biology 2019-02-12 Jason Z. Kim , Danielle S. Bassett

The human brain is a complex system, and understanding its mechanisms has been a long-standing challenge in neuroscience. The study of the functional connectome, which maps the functional connections between different brain regions, has…

Neural and Evolutionary Computing · Computer Science 2025-04-14 Tananun Songdechakraiwut , Yutong Wu

Understanding the mechanisms of neural communication in large-scale brain networks remains a major goal in neuroscience. We investigated whether navigation is a parsimonious routing model for connectomics. Navigating a network involves…

Neurons and Cognition · Quantitative Biology 2018-06-05 Caio Seguin , Martijn P. van den Heuvel , Andrew Zalesky

One important question in neuroscience is how global behavior in a brain network emerges from the interplay between network connectivity and the neural dynamics of individual nodes. To better understand this theoretical relationship, we…

Neurons and Cognition · Quantitative Biology 2022-09-13 Anca Radulescu , Johan Nakuci , Simone Evans , Sarah Muldoon

Complex dynamical systems are often modeled as networks, with nodes representing dynamical units which interact through the network's links. Gene regulatory networks, responsible for the production of proteins inside a cell, are an example…

Statistical Mechanics · Physics 2009-09-30 Zoran Levnajić

The interaction of distinct units in physical, social, biological and technological systems naturally gives rise to complex network structures. Networks have constantly been in the focus of research for the last decade, with considerable…

Physics and Society · Physics 2012-08-20 Tamás Nepusz , Tamás Vicsek

The network paradigm is increasingly used to describe the topology and dynamics of complex systems. Here we review the results of the topological analysis of protein structures as molecular networks describing their small-world character,…

Biomolecules · Quantitative Biology 2007-06-10 Csaba Bode , Istvan A. Kovacs , Mate S. Szalay , Robin Palotai , Tamas Korcsmaros , Peter Csermely

The understanding of neural activity patterns is fundamentally linked to an understanding of how the brain's network architecture shapes dynamical processes. Established approaches rely mostly on deviations of a given network from certain…

Neurons and Cognition · Quantitative Biology 2014-09-19 Marc-Thorsten Huett , Marcus Kaiser , Claus C. Hilgetag

We present an analysis of the topologies of a class of networks which are optimal in terms of the requirements of having as short a route as possible between any two nodes while yet keeping the congestion in the network as low as possible.…

Statistical Mechanics · Physics 2009-11-10 Vittoria Colizza , Jayanth R. Banavar , Amos Maritan , Andrea Rinaldo

Network systems consist of subsystems and their interconnections, and provide a powerful framework for analysis, modeling and control of complex systems. However, subsystems may have high-dimensional dynamics, and the amount and nature of…

Optimization and Control · Mathematics 2020-12-07 Xiaodong Cheng , Jacquelien M. A. Scherpen

We consider the problem of a dynamical network whose dynamics is subject to external perturbations (`attacks') locally applied at a subset of the network nodes. We assume that the network has an ability to defend itself against attacks with…

Systems and Control · Computer Science 2018-06-13 Ishan Kafle , Sudarshan Bartaula , Afroza Shirin , Isaac Klickstein , Pankaz Das , Francesco Sorrentino