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The advent of high-throughput sequencing technologies has revolutionized genome analysis by enabling the rapid and cost-effective sequencing of large genomes. Despite these advancements, the increasing complexity and volume of genomic data…

Genomics · Quantitative Biology 2025-03-06 Can Firtina

Gene studies are crucial for fields such as protein structure prediction, drug discovery, and cancer genomics, yet they face challenges in fully utilizing the vast and diverse information available. Gene studies require clean, factual…

Databases · Computer Science 2024-12-18 Yuwei Miao , Yuzhi Guo , Hehuan Ma , Jingquan Yan , Feng Jiang , Weizhi An , Jean Gao , Junzhou Huang

In this paper we will describe a new approach on the well-known suffix-array algorithm using Big Table Data Technology. We will demonstrate how it is possible to refactor a well-known algorithm coupled by taking advantage of an…

Databases · Computer Science 2020-03-26 Piero Giacomelli

Informatics and technological advancements have triggered generation of huge volume of data with varied complexity in its management and analysis. Big Data analytics is the practice of revealing hidden aspects of such data and making…

Databases · Computer Science 2018-03-30 Bikram Karmakar , Indranil Mukhopadhyay

With the advent of Internet of Things (IoT) and Web 2.0 technologies, there has been a tremendous growth in the amount of data generated. This chapter emphasizes on the need for big data, technological advancements, tools and techniques…

Databases · Computer Science 2017-05-16 Abhay Bhadani , Dhanya Jothimani

Large scale initiatives such as the Human Genome Project, Structural Genomics, and individual research teams have provided large deposits of genomic and proteomic data. The transfer of data to knowledge has become one of the existing…

Databases · Computer Science 2019-11-21 Casey A Cole , Christopher Ott , Diego Valdes , Homayoun Valafar

Genomic signal processing has been used successfully in bioinformatics to analyze biomolecular sequences and gain varied insights into DNA structure, gene organization, protein binding, sequence evolution, etc. But challenges remain in…

Genomics · Quantitative Biology 2022-11-04 Saish Jaiswal , Shreya Nema , Hema A Murthy , Manikandan Narayanan

With tremendous growing interests in Big Data systems, analyzing and facilitating their performance improvement become increasingly important. Although there have much research efforts for improving Big Data systems performance, efficiently…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-11-22 Rui Ren , Jiechao Cheng , Xiwen He , Lei Wang , Chunjie Luo , Jianfeng Zhan

This paper embodies the usage of Big Data in Healthcare. It is important to note that big data in terms of Architecture and implementation might be or has already or will continue to assist the continuous growth in the field of healthcare.…

Cryptography and Security · Computer Science 2019-12-10 Behnam Kiani Kalejahi , Saeed Meshgini , Ayshan Yariyeva , Dawda Ndure , Uzeyir Maharramov , Ali Farzamnia

Organizations are often faced with the challenge of providing data management solutions for large, heterogenous datasets that may have different underlying data and programming models. For example, a medical dataset may have unstructured…

With the rapid growth of modern technology, many large-scale biomedical studies have been/are being/will be conducted to collect massive datasets with large volumes of multi-modality imaging, genetic, neurocognitive, and clinical…

Methodology · Statistics 2018-03-07 Farouk S. Nathoo , Linglong Kong , Hongtu Zhu

Medical diagnosis is a crucial task in the medical field, in terms of providing accurate classification and respective treatments. Having near-precise decisions based on correct diagnosis can affect a patient's life itself, and may…

Machine Learning · Computer Science 2025-08-27 A. Yarkın Yıldız , Asli Kalayci

Objective: To (1) demonstrate the implementation of a data science platform built on open-source technology within a large, academic healthcare system and (2) describe two computational healthcare applications built on such a platform.…

Microarray is a technology to quantitatively monitor the expression of large number of genes in parallel. It has become one of the main tools for global gene expression analysis in molecular biology research in recent years. The large…

Quantitative Methods · Quantitative Biology 2015-06-18 Min Xu

Self-driving labs are transforming drug discovery by enabling automated, AI-guided experimentation, but they face challenges in orchestrating complex workflows, integrating diverse instruments and AI models, and managing data efficiently.…

Software Engineering · Computer Science 2025-04-02 Yao Fehlis , Paul Mandel , Charles Crain , Betty Liu , David Fuller

Technology progress in DNA sequencing boosts the genomic database growth at faster and faster rate. Compression, accompanied with random access capabilities, is the key to maintain those huge amounts of data. In this paper we present an…

Computational Engineering, Finance, and Science · Computer Science 2011-03-14 Szymon Grabowski , Sebastian Deorowicz

Significant investments to upgrade and construct large-scale scientific facilities demand commensurate investments in R&D to design algorithms and computing approaches to enable scientific and engineering breakthroughs in the big data era.…

We highlight the role of Data Science in Biomedicine. Our manuscript goes from the general to the particular, presenting a global definition of Data Science and showing the trend for this discipline together with the terms of cloud…

In DNA computing, it is impossible to decide whether a specific hybridization among complex DNA molecules is effective or not within acceptable time. In order to address this common problem, we introduce a new method based on the machine…

Quantitative Methods · Quantitative Biology 2018-07-03 Weijun Zhu

The present and future of evolutionary algorithms depends on the proper use of modern parallel and distributed computing infrastructures. Although still sequential approaches dominate the landscape, available multi-core, many-core and…

Neural and Evolutionary Computing · Computer Science 2021-03-02 Francisco Fernández de Vega , Gustavo Olague , Francisco Chávez , Daniel Lanza , Wolfgang Banzhaf , Erik Goodman