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We are witnessing the birth of a new variety of pharmacokinetics where non-integer-order differential equations are employed to study the time course of drugs in the body: this is dubbed "fractional pharmacokinetics." The presence of…

Dynamical Systems · Mathematics 2019-04-25 Pantelis Sopasakis , Haralambos Sarimveis , Panos Macheras , Aristides Dokoumetzidis

This paper presents three fractional models formulated from a classical Pharmacokinetics compartmental system: commensurable, non-commensurable, and implicit non-commensurable models. Their distinguishing characteristics are further…

Quantitative Methods · Quantitative Biology 2023-06-16 Reindorf Nartey Borkor , Adu Sakyi , Peter Amoako-Yirenkyi

This study investigates the use of fractional order differential models to simulate the dynamic response of non-homogeneous discrete systems and to achieve efficient and accurate model order reduction. The traditional integer order approach…

Numerical Analysis · Mathematics 2016-12-22 John P. Hollkamp , Mihir Sen , Fabio Semperlotti

Fractional equations have become the model of choice in several applications where heterogeneities at the microstructure result in anomalous diffusive behavior at the macroscale. In this work we introduce a new fractional operator…

Numerical Analysis · Mathematics 2021-01-29 Marta D'Elia , Christian Glusa

This contribution deals with identification of fractional-order dynamical systems. System identification, which refers to estimation of process parameters, is a necessity in control theory. Real processes are usually of fractional order as…

Other Computer Science · Computer Science 2016-11-15 Deepyaman Maiti , Ayan Acharya , R. Janarthanan , Amit Konar

This contribution deals with the creation of numerical models for the simulation of the dynamic characteristics of fractional-order control systems and their comparison with analytical models. We give the results of the comparison of…

Optimization and Control · Mathematics 2007-05-23 L. Dorcak

We present a novel method to improve pharmacokinetics modeling, an essential step of drug development. Conventional models frequently fail to fully represent the intricacies of drug absorption and distribution, which limits their predictive…

Quantitative Methods · Quantitative Biology 2024-12-31 Nazanin Ahmadi , Shupeng Wang , George Karniadakis

This paper presents a data-integrated framework for learning the dynamics of fractional-order nonlinear systems in both discrete-time and continuous-time settings. The proposed framework consists of two main steps. In the first step,…

Systems and Control · Electrical Eng. & Systems 2025-06-19 Bahram Yaghooti , Chengyu Li , Bruno Sinopoli

This paper deals with fractional-order controlled systems and fractional-order controllers in the frequency domain. The mathematical description by fractional transfer functions and properties of these systems are presented. The new ways…

Optimization and Control · Mathematics 2007-05-23 I. Petras , L. Dorcak , P. O'Leary , B. M. Vinagre , I. Podlubny

Modeling of phenomena such as anomalous transport via fractional-order differential equations has been established as an effective alternative to partial differential equations, due to the inherent ability to describe large-scale behavior…

Analysis of PDEs · Mathematics 2021-10-25 Jorge Suzuki , Mamikon Gulian , Mohsen Zayernouri , Marta D'Elia

In this work, we introduce a new three-dimensional chaotic differential dynamical system. We find equilibrium points of this system and provide the stability conditions for various fractional orders. Numerical simulations will be used to…

Chaotic Dynamics · Physics 2020-07-08 Madhuri Patil , Sachin Bhalekar

This paper deals with fractional-order controlled systems and fractional-order controllers in the discrete domain. The mathematical description by the fractional difference equations and properties of these systems are presented. A…

Optimization and Control · Mathematics 2007-05-23 I. Petras , L. Dorcak , I. Kostial

This contribution deals with identification of fractional-order dynamical systems. System identification, which refers to estimation of process parameters, is a necessity in control theory. Real processes are usually of fractional order as…

Other Computer Science · Computer Science 2016-11-15 Deepyaman Maiti , Mithun Chakraborty , Amit Konar

Multi-system interaction is an important and difficult problem in physics. Motivated by the experimental result of an electronic circuit element "Fractor", we introduce the concept of dynamic-order fractional dynamic system, in which the…

Mathematical Physics · Physics 2013-04-10 HongGuang Sun , Hu Sheng , YangQuan Chen , Wen Chen , ZhongBo Yu

Fractional dynamics is a field of study in physics and mechanics investigating the behavior of objects and systems that are characterized by power-law non-locality, power-law long-term memory or fractal properties by using integrations and…

General Physics · Physics 2015-03-12 Vasily E. Tarasov

In this paper, an efficient control strategy for physiological interaction based anaesthetic drug infusion model is explored using the fractional order (FO) proportional integral derivative (PID) controllers. The dynamic model is composed…

Systems and Control · Computer Science 2016-12-01 Saptarshi Das , Sourav Das , Koushik Maharatna

No mixed research of hybrid and fractional-order systems into a cohesive and multifaceted whole can be found in the literature. This paper focuses on such a synergistic approach of the theories of both branches, which is believed to give…

Systems and Control · Computer Science 2014-07-25 S. Hassan HosseinNia , Ines Tejado , Blas M. Vinagre

In this paper we will present some alternative types of mathematical description and methods of solution of the fractional-order dynamical system in the state space. We point out the difference in the true sense of the name "state" space…

Optimization and Control · Mathematics 2007-05-23 L. Dorcak , I. Petras , I. Kostial , J. Terpak

Recent studies have demonstrated the advantages of fractional-order calculus tools for probing the viscoelastic properties of collagenous tissue, characterizing the arterial blood flow and red cell membrane mechanics, and modeling the…

Systems and Control · Electrical Eng. & Systems 2020-10-21 Mohamed A. Bahloul , Taous-Meriem Laleg Kirati

Identification of fractional order systems is considered from an algebraic point of view. It allows for a simultaneous estimation of model parameters and fractional (or integer) orders from input and output data. It is exact in that no…

Optimization and Control · Mathematics 2013-02-19 Nicole Gehring , Joachim Rudolph
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