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Proton therapy has been rapidly advancing due to its excellent conformal index, but its relatively low relative biological effect (RBE) has somewhat limited its therapeutic efficacy for certain tumors. To address this, we previously…
Proton therapy is a cancer treatment technique currently in growth worldwide. It offers advantages with respect to conventional X-ray and $\gamma$-ray radiotherapy, in particular, a better control of the dose deposition allowing to reach a…
To improve the quality of cancer treatment with protons, a translation of X-ray Computed Tomography (CT) images into a map of the proton stopping powers needs to be more accurate. Proton stopping powers determined from CT images have…
Background and purpose: Accelerator-Based Boron Neutron Capture Therapy is a radiotherapy based on compact accelerator neutron sources requiring an epithermal neutron field for tumour irradiations. Neutrons of 10 keV are considered as the…
As depth increases, linear energy transfer (LET) rises toward the distal edge of the Bragg peak, boosting the radiobiological effectiveness (RBE). To manage the biological variation and limit normal-tissue damage, LET-modifying objective…
Proton therapy provides superior dose conformity compared with photon radiotherapy, concentrating radiation within the tumor while sparing adjacent healthy tissue. This advantage has been most effectively realized for static tumors in…
Cancer therapy using protons and heavier ions such as carbon has demonstrated advantages over other radiotherapy treatments. To bring about the next generation of clinical facilities, the requirements are likely to reduce the footprint,…
We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy. Our theoretical model consists of a system of Markov chains…
High-quality proton beams generated by laser-plasma interactions are of significant interest for applications ranging from tumor therapy to fast ignition in inertial confinement fusion. However, simultaneously achieving high energy coupling…
The proton boron fusion reaction, 11B(p, 3{\alpha}), is investigated using MCNP6 to assess the viability for potential use in radiation therapy. The 11B(p, 3{\alpha}) is theoretically desirable because it could combine the localized dose…
Objective: To perform a comprehensive comparative analysis of proton, helium-ion, and carbon-ion computed tomography (CT) as direct imaging modalities for hadron therapy treatment planning, focusing on Relative Stopping Power (RSP)…
Ion beam therapy has become a frequently applied form of cancer therapy over the last years. The advantage of ion beam therapy over conventional radiotherapy using photons is the strongly localized dose deposition, leading to a reduction of…
Computer tomography is one of the most promising new methods to image abnormal tissues inside the human body. Tomography is also used to position the patient accurately before radiation therapy. Hadron therapy for treating cancer has become…
The laser driven acceleration of ions is considered a promising candidate for an ion source for hadron therapy of oncological diseases. Though proton and carbon ion sources are conventionally used for therapy, other light ions can also be…
Selective accumulation of B-10 compound in tumour tissue is a fundamental condition for the achievement of BNCT (Boron Neutron Capture Therapy), since the effectiveness of therapy irradiation derives just from neutron capture reaction of…
The proton-boron (p-$^{11}$B) reaction is regarded as the holy grail of advanced fusion fuels, since the primary reaction produces three $\alpha$ particles with few neutrons and induced radio-activities from second order reactions. Compared…
Proton (and ion) cancer therapy has proven to be an extremely effective even supe-rior method of treatment for some tumors 1-4. A major problem, however, lies in the cost of the particle accelerator facilities; high procurement costs…
Aneutronic and nonradioactive properties make the proton-boron fusion a prospective candidate for fusion energy production through reactions following p+$^{11}$B$\rightarrow$3${\alpha}$ (p-$^{11}$B). However, it is difficult to achieve a…
Photons are exponentially attenuated in matter producing high doses close to the surface. Therefore they are not well suited for the treatment of deep seated tumours. Charged particles, in contrast, exhibit a sharp increase of ionisation…
Proton acceleration by high-intensity laser pulses from ultra-thin foils for hadron therapy is discussed. With the improvement of the laser intensity contrast ratio to 10-11 achieved on Hercules laser at the University of Michigan, it…